ID U2NVX1_ENTFC Unreviewed; 272 AA.
AC U2NVX1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Pur operon repressor {ECO:0000256|ARBA:ARBA00018449};
GN ORFNames=I131_02300 {ECO:0000313|EMBL:ERK32961.1};
OS Enterococcus faecium CRL1879.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1295527 {ECO:0000313|EMBL:ERK32961.1, ECO:0000313|Proteomes:UP000016582};
RN [1] {ECO:0000313|EMBL:ERK32961.1, ECO:0000313|Proteomes:UP000016582}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CRL1879 {ECO:0000313|EMBL:ERK32961.1,
RC ECO:0000313|Proteomes:UP000016582};
RX PubMed=23868133;
RA Suarez N.E., Saavedra L., Slozilova I., Bonacina J., Demnerova K.,
RA Sesma F.;
RT "Draft Genome Sequence of Enterococcus faecium Strain CRL 1879, Isolated
RT from a Northwestern Argentinian Artisanal Cheese.";
RL Genome Announc. 1:E00514-13(2013).
CC -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC family. {ECO:0000256|ARBA:ARBA00008391}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERK32961.1}.
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DR EMBL; AOUK01000065; ERK32961.1; -; Genomic_DNA.
DR AlphaFoldDB; U2NVX1; -.
DR Proteomes; UP000016582; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0045982; P:negative regulation of purine nucleobase metabolic process; IEA:InterPro.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR015265; PuR_N.
DR InterPro; IPR010078; PurR_Bsub.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR01743; purR_Bsub; 1.
DR PANTHER; PTHR43864; HYPOXANTHINE/GUANINE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43864:SF2; PUR OPERON REPRESSOR; 1.
DR Pfam; PF00156; Pribosyltran; 1.
DR Pfam; PF09182; PuR_N; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 4..73
FT /note="Bacterial purine repressor N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09182"
FT DOMAIN 108..249
FT /note="Phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00156"
SQ SEQUENCE 272 AA; 30304 MW; 8813F9A003C1E247 CRC64;
MKVRRSERLV DMTQYLLNHP HELISLTSFA ERYESAKSSI SEDLGIIKKT FKERGYGTLE
TIPGAAGGVL FIPEISYEEA KKYIESLAER LSEQDRLLPG GYVYLSDLLG EPELLRQVGR
IIASKYLGEK IDAVMTVATK GVPIAQAVSY YLNAPFVIVR RDSKITEGST VSVNYVSGSS
ERIEKMELSK RSLKRGSRVL VVDDFMKGGG TVNGMKSLIE EFESELVGIT VFAESKFNGH
RAIDDYTSLL YVKDVDTQTK NITVVPGNYF SE
//
