ID U2SQU0_9FUSO Unreviewed; 677 AA.
AC U2SQU0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:ERK67748.1};
GN ORFNames=HMPREF1984_01003 {ECO:0000313|EMBL:ERK67748.1};
OS Leptotrichia sp. oral taxon 215 str. W9775.
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Leptotrichiaceae;
OC Leptotrichia.
OX NCBI_TaxID=1321779 {ECO:0000313|EMBL:ERK67748.1, ECO:0000313|Proteomes:UP000016640};
RN [1] {ECO:0000313|EMBL:ERK67748.1, ECO:0000313|Proteomes:UP000016640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W9775 {ECO:0000313|EMBL:ERK67748.1,
RC ECO:0000313|Proteomes:UP000016640};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERK67748.1}.
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DR EMBL; AWVR01000031; ERK67748.1; -; Genomic_DNA.
DR RefSeq; WP_021766115.1; NZ_KI272826.1.
DR AlphaFoldDB; U2SQU0; -.
DR STRING; 1321779.HMPREF1984_01003; -.
DR PATRIC; fig|1321779.3.peg.967; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_2_0; -.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000016640; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..261
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 293..617
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 631..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 677 AA; 76233 MW; 7D0E06D66A64AC8B CRC64;
MRELDKEGRS PRYIAFISLV TLVFLIFIGR LFAIQILEAS KYEERALQNR IRTNIIKATR
GEIYDRNGKL LAKNITGYML VHYATKQIDS TDTKILREIQ SFNMDQIRER LSKEKKSRQE
KLLETIIDIK KISELTGYTT DYIITRFFKQ PRIGTDKSIL VIEDLDKNIA LKAIEKIDNN
RIDIVEYNKR FYPEDSIASH VIGNVKPIDE KEYEKLKEEG YQNTDLIGKK GVEKQYDKEM
KGQDGVENVE VDAKGNTIRR LENTDSIAGK SIYLSIDLEL QKYMTKAFEG ESGAFIAMEA
KTGKIITFVS YPEISLNLLS SRIPDAQWNE LVNSKSKPLV NKGIAGLYPP GSTYKAVTGV
AILESGISPY ESVVSTGQYR YKGLVFRDSS KSGHGVTNFN KSIEQSVNTY YYVFSQKAGL
DNVIKYSKEF GIGEKTGIDI PGELPGTLPT PEWKKKRFKN SKNPGDRTWL PGDLINMSIG
QGYVLTTPLQ IASVYQIIAN NGVMMKPTVV DKFMLYDGKM EINKPQVVRK VNISEKTLKL
MQNALRLPVA GAGGTAKILR FNDFPVSAKT GTAQNTGFKD HHSWIAGYFP SNNPEIVFVS
IVEGGGYGGT ASGNMARIFI EKYRELDRAR KNAAAAEEAK KQQQNNQNNQ NSQNNQNGQN
NVAVQNNGQR KRRGNKR
//