ID U2V4V9_9ACTN Unreviewed; 603 AA.
AC U2V4V9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Adenine deaminase {ECO:0000256|ARBA:ARBA00012782, ECO:0000256|HAMAP-Rule:MF_01518};
DE Short=Adenase {ECO:0000256|HAMAP-Rule:MF_01518};
DE Short=Adenine aminase {ECO:0000256|HAMAP-Rule:MF_01518};
DE EC=3.5.4.2 {ECO:0000256|ARBA:ARBA00012782, ECO:0000256|HAMAP-Rule:MF_01518};
GN Name=ade {ECO:0000256|HAMAP-Rule:MF_01518};
GN ORFNames=HMPREF1316_1948 {ECO:0000313|EMBL:ERL10387.1};
OS Olsenella profusa F0195.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC Olsenella.
OX NCBI_TaxID=1125712 {ECO:0000313|EMBL:ERL10387.1, ECO:0000313|Proteomes:UP000016638};
RN [1] {ECO:0000313|EMBL:ERL10387.1, ECO:0000313|Proteomes:UP000016638}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0195 {ECO:0000313|EMBL:ERL10387.1,
RC ECO:0000313|Proteomes:UP000016638};
RA Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000479, ECO:0000256|HAMAP-
CC Rule:MF_01518};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01518};
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenine deaminase family. {ECO:0000256|ARBA:ARBA00006773,
CC ECO:0000256|HAMAP-Rule:MF_01518}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERL10387.1}.
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DR EMBL; AWEZ01000010; ERL10387.1; -; Genomic_DNA.
DR RefSeq; WP_021725119.1; NZ_AWEZ01000010.1.
DR AlphaFoldDB; U2V4V9; -.
DR STRING; 1125712.HMPREF1316_1948; -.
DR PATRIC; fig|1125712.3.peg.328; -.
DR eggNOG; COG1001; Bacteria.
DR OrthoDB; 9766983at2; -.
DR Proteomes; UP000016638; Unassembled WGS sequence.
DR GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR HAMAP; MF_01518; Adenine_deamin; 1.
DR InterPro; IPR006679; Adenine_deam.
DR InterPro; IPR026912; Adenine_deam_C.
DR InterPro; IPR006680; Amidohydro-rel.
DR InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR InterPro; IPR032466; Metal_Hydrolase.
DR PANTHER; PTHR11113:SF2; ADENINE DEAMINASE; 1.
DR PANTHER; PTHR11113; N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE; 1.
DR Pfam; PF13382; Adenine_deam_C; 1.
DR Pfam; PF01979; Amidohydro_1; 1.
DR SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01518};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|HAMAP-Rule:MF_01518};
KW Reference proteome {ECO:0000313|Proteomes:UP000016638}.
FT DOMAIN 84..372
FT /note="Amidohydrolase-related"
FT /evidence="ECO:0000259|Pfam:PF01979"
FT DOMAIN 429..595
FT /note="Adenine deaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13382"
SQ SEQUENCE 603 AA; 64586 MW; 2463C50F585C4860 CRC64;
MINSYCKKPL WECNGTLVRV AQGQQAADTV IKDVRLVSVT THEVLERTDI ALSCGRVAYL
GIDGHSADHC IGAGTTVVDA HGLYATPGLL DSHIHIESSM VGPSEYARAV VPHGTTGLYA
DPHEVANVRG LEGVRAMWAD AARTPLKAML TTPSCVPAVT GVEDTGADIG AADVAQTMAW
SETCALGEMM NFPGVLSCEE RPLDEIRETL RADRVVTGHY VSADTDRGLN AYVASGVSSC
HESGSFDEVL AKLRLGMHAQ LRQGSAWLNL PGYLPRLIES GVDTRLCMLC TDDSHPHTIV
GDGHMDRVLR TAVGLGLDPV TAVQMATTNT ATYFGVGRDM GAVVPGACAD IVLWDDLKDF
RARMVWIDGE LVAQDGRALF EVGPFAWPMF MTNTMELGDL LTPEAFQFAC DRPDGHCMVH
AIEVNAGDTI TRDAIVEVPV HDGLLQADPA HDILKLCVFD RHHGGAGTYS HGFATGFGVH
GALAQTVSHD AHNLLVMGDN DADMLLAART LEACGGGEVA VQEGRVLALV ELPVCGLMSD
KPVEVVSDEV SRIEEAWRQM GCRLPSPFMT MGVMSLACVP VLRQTNRGYV NCTTFETEPL
IAD
//
