ID U2V9X8_9ACTN Unreviewed; 215 AA.
AC U2V9X8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Epoxyqueuosine reductase QueH {ECO:0000256|ARBA:ARBA00016895};
DE EC=1.17.99.6 {ECO:0000256|ARBA:ARBA00012622};
DE AltName: Full=Queuosine biosynthesis protein QueH {ECO:0000256|ARBA:ARBA00031446};
GN ORFNames=HMPREF1248_0898 {ECO:0000313|EMBL:ERL12132.1};
OS Coriobacteriaceae bacterium BV3Ac1.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales;
OC Coriobacteriaceae.
OX NCBI_TaxID=1111135 {ECO:0000313|EMBL:ERL12132.1, ECO:0000313|Proteomes:UP000016652};
RN [1] {ECO:0000313|EMBL:ERL12132.1, ECO:0000313|Proteomes:UP000016652}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BV3AC1 {ECO:0000313|Proteomes:UP000016652};
RA Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine
CC (Q), which is a hypermodified base found in the wobble positions of
CC tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
CC {ECO:0000256|ARBA:ARBA00002268}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in
CC tRNA; Xref=Rhea:RHEA:32159, Rhea:RHEA-COMP:18571, Rhea:RHEA-
CC COMP:18582, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499,
CC ChEBI:CHEBI:194431, ChEBI:CHEBI:194443; EC=1.17.99.6;
CC Evidence={ECO:0000256|ARBA:ARBA00035072};
CC -!- PATHWAY: tRNA modification; tRNA-queuosine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004691}.
CC -!- SIMILARITY: Belongs to the QueH family.
CC {ECO:0000256|ARBA:ARBA00008207}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERL12132.1}.
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DR EMBL; AWUP01000011; ERL12132.1; -; Genomic_DNA.
DR AlphaFoldDB; U2V9X8; -.
DR PATRIC; fig|1111135.3.peg.1136; -.
DR eggNOG; COG1636; Bacteria.
DR UniPathway; UPA00392; -.
DR Proteomes; UP000016652; Unassembled WGS sequence.
DR GO; GO:0052693; F:epoxyqueuosine reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0008616; P:queuosine biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR003828; QueH.
DR PANTHER; PTHR36701; EPOXYQUEUOSINE REDUCTASE QUEH; 1.
DR PANTHER; PTHR36701:SF1; EPOXYQUEUOSINE REDUCTASE QUEH; 1.
DR Pfam; PF02677; QueH; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000016652}.
SQ SEQUENCE 215 AA; 24734 MW; 8C37FF59F1559E88 CRC64;
MEKQSTTIMF PPQGIAPHPG TPLLLHACCG PCSLEPLKLL RQEGWDPLIC WTNPNIAPVA
EHDLRLRTLQ AWAHDIAHVD VIVAGDDRES WERKVAPARL KRERRCRACY AQRLEESCRV
AVEQGFEYIS TTLVVSPYQL FEVCHEVLFA LAHRYGLTPV WRDFRPYYPE ATIESRELNM
YRQNYCGCRF SAAEAALDRQ QARDVRKAAR KKQLG
//
