ID U3BDC8_CALJA Unreviewed; 843 AA.
AC U3BDC8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Complement component C7 {ECO:0000313|EMBL:JAB04227.1};
GN Name=C7 {ECO:0000313|EMBL:JAB04227.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB04227.1};
RN [1] {ECO:0000313|EMBL:JAB04227.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB04227.1}, Cerebellum
RC {ECO:0000313|EMBL:JAB42873.1}, and Cerebral cortex
RC {ECO:0000313|EMBL:JAB25045.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; GAMT01007634; JAB04227.1; -; mRNA.
DR EMBL; GAMT01007633; JAB04228.1; -; mRNA.
DR EMBL; GAMR01008887; JAB25045.1; -; mRNA.
DR EMBL; GAMR01008886; JAB25046.1; -; mRNA.
DR EMBL; GAMR01008885; JAB25047.1; -; mRNA.
DR EMBL; GAMR01008884; JAB25048.1; -; mRNA.
DR EMBL; GAMP01009882; JAB42873.1; -; mRNA.
DR RefSeq; XP_002745085.2; XM_002745039.4.
DR AlphaFoldDB; U3BDC8; -.
DR GeneID; 100385053; -.
DR KEGG; cjc:100385053; -.
DR CTD; 730; -.
DR OrthoDB; 5303272at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR048827; C7_FIM2_N.
DR InterPro; IPR048825; C7_KAZAL.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR040729; Kazal_3.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF2; COMPLEMENT COMPONENT C7; 1.
DR Pfam; PF21284; C7_FIM2_N; 1.
DR Pfam; PF21330; C7_KAZAL; 1.
DR Pfam; PF18434; Kazal_3; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00084; Sushi; 2.
DR Pfam; PF00090; TSP_1; 2.
DR PRINTS; PR00764; COMPLEMENTC9.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50092; TSP1; 2.
PE 2: Evidence at transcript level;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..843
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010152118"
FT DOMAIN 124..456
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 569..628
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 629..690
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 114..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 91..109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 599..626
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 843 AA; 93404 MW; D6CADEBFAC6C2FF6 CRC64;
MKAISLLILV GFTGEFQIFS SASSPVNCQW ESYAPWSECN GCTKTQTRRR SVAVYAQYGG
QPCIGSAFET QSCKPTRGCP TEEGCGERFR CFSGQCISKL LVCNGDSDCE EDGADEDRCE
DSERRPSCDI DKPPPNIELT GNGYNALTGQ FRNRVINTKS FGGQCRKVFS GDGRDFYRLS
GNVLSYTFQV KVNNDFNYEF YNSTWSYVKC TSTEHTSSSK KRSFFRSSSS SSHSYTSHTN
EIHKEKSYQL LVVENTVEVA QFINNNPEFL QLAEPFWKEL SHLPSLYDYS AYRRLIDQYG
THYLQSGSLG GEYRVLFYVD SEKFKQKDFG SVEGKNCKSS GWHFLFSSSR HKCKEMEDAL
KSDSGTHSNV MRGDPFVRGG AAGFVSGLSY LELDNPAGNK RRYSSWAESV TNLPQVIKQK
LTPLYELVKD VPCASVKKLY LKRALEEYLD EFDLCHCQPC QNGGLATVEG THCVCHCKPY
TFGAACEKGV LIGNQAGGVD GGWSCWSSWS PCVQGKKTRS RECNNPPPSE GGRSCIGETT
ESAQCEDEEL EHLRMLEPHC FPLSLVPTEY CPSPPALKDG FVQDEGTMFP VGKNVLYTCN
EGYSLIGNPV ARCGEDLRWL VGDMRCQKIA CVLPVLMDGI QSHPHKPFYA VGEKVTVSCS
GGMSLEGPSA FLCGSSLKWS PEMKNVRCVQ KDTPLTQAVP KCQLWEKLQN SRCVCKMPYE
CGSSLDVCAQ DERSKRILPL TVCKLHVLHC QGRNYTLTGM DSCTLPASAE KACGACPLWG
KCDAESSKCV CREASECEEE GFSICVEMNG KEQTMSECEV GALRCTGRSI SVISIKPCAV
PTQ
//
