ID U3BUA0_CALJA Unreviewed; 4349 AA.
AC U3BUA0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Protocadherin Fat 2 {ECO:0000313|EMBL:JAB09424.1};
GN Name=FAT2 {ECO:0000313|EMBL:JAB09424.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB09424.1};
RN [1] {ECO:0000313|EMBL:JAB09424.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB09424.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GAMT01002437; JAB09424.1; -; mRNA.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 32.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 33.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF448; FAT ATYPICAL CADHERIN 2; 1.
DR Pfam; PF00028; Cadherin; 29.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 33.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 33.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00232; CADHERIN_1; 12.
DR PROSITE; PS50268; CADHERIN_2; 32.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..4349
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004640502"
FT TRANSMEM 4049..4069
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..148
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 149..256
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 363..458
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 459..564
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 565..669
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 716..820
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 821..925
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 926..1032
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1033..1137
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1138..1242
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1243..1334
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1350..1448
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1449..1555
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1556..1660
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1661..1758
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1759..1872
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1969..2070
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2071..2171
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2172..2272
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2273..2379
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2380..2481
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2482..2585
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2586..2691
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2692..2797
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2798..2906
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2907..3011
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3012..3113
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3114..3218
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3219..3321
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3322..3426
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3427..3531
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3532..3642
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3773..3944
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3947..3984
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3986..4022
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 3974..3983
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4012..4021
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4349 AA; 480354 MW; E232098714350607 CRC64;
MTIALLGFAI FLLHSATCEK PTDGILSSSA WHFTHSHYNA TIYENSSPKT YVESLEKMGI
YLAEPQWAVR YRIISGDVAN VFKTEEYVVG NFCFLRIRTK SSNTALLNRE VRDSYTLIIQ
ATEKTLELEA LTRVVVHILD QNDLKPLFSP PSYRVTISED TPLKSPICKV TATDADLGQN
AEFYYNFNTR SEMFAIHPTS GVVTVAGKLN VTWRGKHELQ VLAVDRMRKI SEGNGFGSLA
ALVIHVEPAL RKPPAIASVV VTPPDSNDGT TYATVLVDAN SSGAEVESVE VVGGDPGKHF
KAIKSYARSN EFSLVSVKDI NWMEYLHGFN LSLQARSGSG PYFYSQIRGF HLPPSKLASL
KFEKAVYRVQ LSEFSPPGSR VVMVRVTPAF PDLQYVLKPS SENLGFKLNA RTGLITTTKL
MDFHDRAHYQ LHIRTSPGQA STVVVIDIVD CNNHAPVFNR SSYDGTLDEN IPPGTSVLAA
TATDQDHREN GYVTYSIAGP KALPFSIDPY LGIISTSKPM DYELMKRIYT FRVRASDWGS
PFRREKEVSV FLQLRNLNDN QPMFEEVNCT GSIRQDWPVG KSIMTMSAID VDELQNLKYE
IVSGNELEYF DLNHFSGVIS LKRSFMNLTA GQPVSYSLKI TASDGKHYAS PTTLNITVVK
DPHFEVPITC DKTGVLTQFT KTILHSIGLQ NQESSDEEFT SLSTYQINHY TPQFEDHFPQ
SIDVLESVPV NTSLARLAAT DPDAGFNGKL VYVIADGNEE GCFDIELETG LLTIAAPLDY
ETTNFYILNV TVYDLGTPQK SSWKLLTVNV KDWNDNAPRF PPGGYQLTIS EDTEVGTTIA
ELTTKDADSE DNGRVRYTLL SPTEKFSLHP LTGELVVTGH LDRESEPQYI LKVEARDQPR
KGHQLFSVTD LIVTLEDVND NSPQCITELN RLKVPEDLPP GTVLTFLDAS DPDLGPAGEV
RYVLMDDAHG TFRVDLTTGA LSLERELDFE RRAGYNLSLW ASDSGRPLAR RTLCHVEVIV
LDVNENLHPP HFASFVHQGQ VQENSPSGTQ VMVVAAHDDD SGLDGELQYF LRAGTGLAAF
SINQDTGMIQ TLAPLDREFA SYYWLTVLAV DRGSVPLSSV TEVYIEVTDA NDNPPQMSRA
VFYPSIQEDA PVGTSVLQLD ASDPDSSSKG KLTFNITSGN HMGFFIIHPV TGLLSTARQL
DRENKDEHIL EVTVLDNGEP PLKSTSRVVV GILDINDNPP AFSHKLFNVR LPERLSPVSP
GPVYRLVASD LDEGLNGRVT YSIEESDEEG FSIDPVTGVV SSSSIFTAGE YNILTIKATD
NGQPPLSASV RLHIEWIPRP RPSSIPLAFD ETHYSFTVME TDPVNHMVGV ISVEGRPGLF
WFNISGGDKD MDFDIEKTTG SIIIARPLDT RRRSNYNLTV EVTDGSRTIA TQVHIFMIAN
INHHRPQFLE THYEVRVPQD TLPGVELLRV QAIDQDKGKG LIYTIHGSQD PGSASLFQLD
PSSGVLVTVG KLDLRSGPSQ HTLTVMVRDQ EIPIKRNFVW VTIHVENGNL HPPYFTQLHY
EASVPDTTAP GTELLQVRAM DADRGANAEV RYTLLKGNGE GFFNINALLG IITLARKLDW
ANHAPHTLTV KAEDQGSPQW HDLATVIIHV YPSDRSAPIF SKTEYFVEIP ESIPVGSPIL
LVSAMSSSEV TYELREGNKD GVFSMNSYSG LMSTQKNLDH EKISSYQLKI RGSNMAGAFT
DVMVVVDIID ENDNAPMFLK STFVGQISEA APLYSMIMDK NNNPFVIHAS DSDKEANSLL
VYKILEPEAL KFFKIDPSMG TLTIVSEMDY ESRPSFKFCV YVHDQGNPIL FAPRPAQVII
NVRDVNDSPP RFSEQIYEVA IVGPIHPGME LLMVQASDDD SEVNYSIKTG NADEAVTIHP
ITGRISVLNP AFMGLSRKLT IRASDGLYQD TALVKIYLNQ VLDKSLQFDQ DVYRATVREN
LQDRKTLVIL GAQGNYLNDT LSYFLLNGTD MFHMVQSAGV LQTRGVVFDR EQQDTHELAV
EVRDNRTPQR IAQALVQVSI EDVNDNPPKF KHLPYYTIIQ DGTEPGDVLF QVSATDEDLG
TNGAITYTFA EDYTYFRIDP YLGDISLRKP FDYQALNKYR LKVIARDGGM PSLQSEEEVL
VTVRNKSNPL FQSPYYKVRV PENITLYTPI LHTQARSPEG LRLIYNIVEE EPLMLFTTDF
KTGVLTVTGP LDYESKTKHV FTVRATDTAL GSFSEATVEV LVEDVNDNPP TFSQLVYTTS
ISEGLPAQTP VIQLLASDQD SGRNRDVSYQ IVEDGSDVSK FFQINGSTGE MSTVQELDYE
AQQHFHVKVR AMDKGDPPLT GETLVVVNVS DINDNPPEFR QSQYEANVSE LATCGHLVLR
VQAIDPDSRD TSRLQYLILS GNQDRHFSIN SSSGIISMFN LCKKHLDSSY NLRVGASDGV
FRATVPVYIN TTNANKYSPE FQQHLYEAEL AENAMVGTKV IDLLAIDKDS GPYGTIDYTI
INKLASEKFS INPNGQIATL QKLDRENSTE RVIAIKVMAQ DGGGRVAFCT VKIILTDEND
NPPQFKASAY TVSIQSNVSK DSPVIQVLAY DADEGQNADV TYSVNPEDLV KDVIEINPVT
GVVKVKDSLV GLENRTIDFI IKAQDGGPPH WNSQVPVRLQ VVPKKVSLPK FSEPLYTFPA
SEDLPEGSEI GVVKAVAAHD PVIYSLVRGT TPESNKDGVF SLDPDTGVIK VRKTMDHEST
KLYQIDVMAH CLQNTDVVSL VSVNIQVIDV NDNRPVFEAD PYKAVLTENM PVGTSVIQVT
AIDKDTGRDG QVSYRLSADP SSNVHELFAI DSESGWITTL QELDCETCQT YNFHVVAYDH
GRTIQLSSQA LVQVSITDEN DNAPRFASEE YRGSVIENSE PGELVATLKT LDADISEQNR
QVTCYITEGD PLGQFGISQV EDEWRISSRK TLDREHMAKY LLRVTASDGK FQASVTVEIF
VLDVNDNSPQ CSQLLYTGKV HEDVFPGHFI LKVSATDLDA DTNAQITYSL HGPGAHEFKL
DPHTGELTTL TPLDRERKDV FNLVAKATDG GGRSCQADVT LHVEDVNDNA PRFFPSHCAV
AVFDNTTVKT PVAVVFARDP DQGPNAQVVY SLPDSAEGHF SIDATTGVIR LEKPLQVRPQ
APLELTVRAS DLGTPIPLST LSTVTVSVVG LEDYLPVFLN TEHSVQVPED TPPGTEVLQL
APLTRPGAEK TGYRVVSGNE QGRFRLDART GILYVNASLD FETSPKYFLS IECTRKSSSS
LSDITTVVVN ITDVNEHRPR FPQDPYNTRV LENALVGDVI LTVSATDEDG PLNSDITYSL
VGGNQLGHFI IHPKKGELQV AKALDWEQAS SYSLKLRATD SGQPPLHEDT DIAIQVADVN
DNPPRFFQLN YSTTVQENSP IGSKVLQLIL SDLDSPENGP PYSFRITKGN TGSAFRVTPD
GWLVTAEGLS KRVQEWYQLQ IQASDSGIPP LSSSTSVRIH VTEKSHYAPS ALPLEIFITV
GEEEFQGGMV GKIHATDRDP QDTLTYSLAE EETLGRYFSV GTPDGKIIAA QSLPCGRYSF
NVTVSDGTFT TTAGVHVYVW HVGREALQQA VWMGFYQLTP EELVSDHWRN LQRFLSHKLD
IKRANIHLAS LQPAEAVAGV DVLLVFEGHS GTFYELQELA SIIIHSAKEM EHSVGVQMRS
AMPVVPCQGP TCQGQICHDT VHMDPKVGPT YSTARLSILT PRHRLQRSCS CNGTAARFSG
QSYVRYRPPA ARNWHISFYL KTLQPQAILL FTNETASISL KLASGVLQLE YHCLGGFYGN
LSSQRHVNDH EWHFILVEET DTSIRLMVDS MGNASLVVPE NCHGLRPERH LFLGGLVLSH
SSFNVSQGFE GCLDAVMVNE EALELLVPDK MVAGLLETQA LTQCCPHSNY CSQNPCLNGG
KCLWTHRAGY VCKCPPQFSG KHCEQGRENC TFAPCLEGGT CIPSPKGASC NCPHPYTGDR
CEMEARGCSE GHCLVTPEIK RGDWGQQELL IIVVTIVFII ISTVGLLYYC RRCKSHKPVA
MEDPDLLARS VGVDTQAMPA IELNPLSASS CNNLNQPEPS KTSVPNELVT FAPNSKQRPV
VCSVPPRLPP AAVPSHSDNE PVIKRTWSGE EMVYPGGATV WPPTYSRNER WEYPHSEVTH
GPLPPSTHRH STPVVMPEPA GLYGGFPFPL EMENKRAPLP PRYSNQNLED LMPSRPPSPR
ERLLAPCLNE YTAISYYHSQ FRQGGGGPSL AEGGYKGVSM RLSRAGPSYA VCEVEGAPLA
GQGQPRAPPI YEGSDMVESD YGSCEEVMF
//
