ID U3DH06_CALJA Unreviewed; 1215 AA.
AC U3DH06; F7GVT0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
GN Name=EIF5B {ECO:0000313|EMBL:JAB29199.1,
GN ECO:0000313|Ensembl:ENSCJAP00000018442.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB29199.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000018442.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB29199.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebellum {ECO:0000313|EMBL:JAB48665.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB29199.1}, Hippocampus
RC {ECO:0000313|EMBL:JAB20047.1}, and Skeletal muscle
RC {ECO:0000313|EMBL:JAB40241.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000018442.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GAMS01003089; JAB20047.1; -; mRNA.
DR EMBL; GAMR01004733; JAB29199.1; -; mRNA.
DR EMBL; GAMR01004732; JAB29200.1; -; mRNA.
DR EMBL; GAMQ01001610; JAB40241.1; -; mRNA.
DR EMBL; GAMP01004090; JAB48665.1; -; mRNA.
DR EMBL; GAMP01004089; JAB48666.1; -; mRNA.
DR Ensembl; ENSCJAT00000019486.3; ENSCJAP00000018442.3; ENSCJAG00000009960.5.
DR eggNOG; KOG1144; Eukaryota.
DR GeneTree; ENSGT00940000162583; -.
DR HOGENOM; CLU_002656_0_1_1; -.
DR OMA; EFAVMLC; -.
DR TreeFam; TF101535; -.
DR Proteomes; UP000008225; Chromosome 14.
DR Bgee; ENSCJAG00000009960; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:Ensembl.
DR GO; GO:0003924; F:GTPase activity; IEA:Ensembl.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:Ensembl.
DR GO; GO:0006446; P:regulation of translational initiation; IEA:Ensembl.
DR GO; GO:0042255; P:ribosome assembly; IEA:Ensembl.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd16266; IF2_aeIF5B_IV; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 2: Evidence at transcript level;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:JAB29199.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 624..841
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..509
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..564
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1215 AA; 138001 MW; 71E95ACEC4F16D99 CRC64;
MGKKQKNKSE DSAKDDIDLD ALAAEIEGAG AAKEQEPQKS KGKKKKEKKK QDFDEDDILK
ELEELSLEAQ GIKADRETIA VKPTENNEEE FTSKQDKKKK GQKGKKQSFD DNDSEELEDS
KSKKTAKPKV AMYSGSDDDD DFNKLPKKAK GKAQKSNKKW DGSEEDEDNS NKIKEHSGVN
SSGESLDESD EFLSSRKGQK KNQKNKPGPN IESGNEDDDS SFKIKTVAQK KAEKKERERK
KRDEEKAKLR KLKEKEELET GKKDLSKQKE SQRKSEEETE KSKVTLDTGV ILASEEKAET
PTAAEDDNEG DKKKKDKKKK KGEKEEKEKK KGPSKATVKA MQEALAKLKE EEERQKREEE
ERIKRLEELE AKRKEEERLE QEKRERKKQK EKERKERLKK EGKLLTKSQR EARARAEATL
KLLQAQGVEV PSKDSLPKKR PVYEDKKRKK IPQQLESKEV SESMELCAAV EVMDQGVPEK
EETPPPVEPE EEEDTEDTGL DDWEAMASDE ETEKEGNTVH IEVKENPEEE EEEEEEEEDE
ESEEVEEEEG ESEGSEGDEE DEKVSDEKDS GKTLDKKPSK EMSSDSEYDS DDDRTKEERA
YDKAKRRIEK RRLEHSKNVN TEKLRAPIIC VLGHVDTGKT KILDKLRHTH VQDGEAGGIT
QQIGATNVPL EAINEQTKMI KNFDRENVRI PGMLIIDTPG HESFSNLRNR GSSLCDIAIL
VVDIMHGLEP QTIESINLLK SKKCPFIVAL NKIDRLYDWK KSPDSDVAAT LKKQKKNTKD
EFEERAKAII VEFAQQGLNA ALFYENKDPR TFVSLVPTSA HTGDGMGSLI YLLVELTQTM
LSKRLAHCEE LRAQVMEVKA LPGMGTTIDV ILINGRLKEG DTIIVPGVEG PIVTQIRGLL
LPPPMKELRV KNQYEKHKEV EAAQGVKILG KDLEKTLAGL PLLVAYKEDE IPVLKDELIH
ELKQTLNAIK LEEKGVYVQA STLGSLEALL EFLKTSEVPY AGINIGPVHK KDVMKASVML
EHDPQYAVIL AFDVRIERDA QEMADSLGVR IFSAEIIYHL FDAFTKYRQD YKKQKQEEYK
HIAVFPCKMK ILPQYIFNSR DPIVMGVTVE AGQVKQGTPM CVPSKNFVDI GIVTSIEINH
KQVDVAKKGQ EVCVKIEPIP GESPKMFGRH FEATDILVSK ISRQSIDALK DWFRDEMQKS
DWQLIVELKK VFEII
//
