ID U3DYY3_CALJA Unreviewed; 1642 AA.
AC U3DYY3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Roundabout homolog 1 isoform a {ECO:0000313|EMBL:JAB18561.1};
GN Name=ROBO1 {ECO:0000313|EMBL:JAB18561.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB18561.1};
RN [1] {ECO:0000313|EMBL:JAB18561.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Hippocampus {ECO:0000313|EMBL:JAB18561.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
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DR EMBL; GAMS01004575; JAB18561.1; -; mRNA.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008046; F:axon guidance receptor activity; IEA:InterPro.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:InterPro.
DR GO; GO:0035385; P:Roundabout signaling pathway; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd07693; IgC_1_Robo; 1.
DR CDD; cd05724; IgI_2_Robo; 1.
DR CDD; cd05725; IgI_3_Robo; 1.
DR CDD; cd05726; IgI_4_Robo; 1.
DR CDD; cd20952; IgI_5_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR032986; Robo1_Ig-like3.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF32; MYOTILIN; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00406; IGv; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 2: Evidence at transcript level;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1642
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004640223"
FT DOMAIN 68..164
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 170..257
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 262..346
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 351..446
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 455..541
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 563..657
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 676..773
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 778..874
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 33..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1072..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1343..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1411..1642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1299
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1429..1446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1484
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1507..1530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1545..1568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1581..1612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1642 AA; 180181 MW; 574A4C34C158B139 CRC64;
MKWKHVPFLV IISLLSLSPN HLLLAQLIPD PEDLERGNDH GTPIPTSDND DNSLGYTGSR
LRQEDFPPRI VEHPSDLIVS KGEPATLNCK AEGRPTPTIE WYKGGERVET DKDEPRSHRM
LLPSGSLFFL RIVHGRKSRP DEGVYVCVAR NYLGEAVSHN ASLEVAILRD DFRQNPSDVM
VAVGEPAVME CQPPRGHPEP TISWKKDGSP LDDKDERITI RGGKLMITYT RKSDAGKYVC
VGTNMVGERE SEVAELTVLE RPSFVKRPSN LAVTVDDSAE FKCEARGDPV PTVRWRKDDG
ELPKSRYEIR DDHTLKIRKV MAADMGSYTC VAENMVGKAE ASATLTVQEP PHFVVKPRDQ
VVALGRTVTF QCEATGNPQP AIFWRREGSQ NLLFSYQPPQ SSSRFSVSQT GDLTITNVQR
SDVGYYICQT LNVAGSIITK AYLEVTDVIA DRPPPVIRQG PVNQTVAVDG TFVLSCVATG
SPVPTILWRK DGVLVSTQDS RIKQLENGVL QVRYAKLGDT GRYTCIASTP SGEATWSAYI
EVQEFGVPVQ PPRPTDPNLI PSAPSKPEVT DVSRNTVTLS WQPNLNSGAT PTSYIIEAFS
HASGSSWQTV AENVKTETFA IKGLKPNAIY LFLVRAANAY GISDPSQISD PVKTQDVPPT
SQGVDHKQVQ RELGNVVLHL HNPTILSSSS VEVHWTVDQQ SQYIQGYKIL YRPSGARHGE
SEWLVFEVRT PTKNSVIISD LKKGVNYEIK ARPFFNEFQG ADSEIKFAKT LEEAPSAPPQ
GVTVSKNDGN GTAILVSWQP PPEDTQNGMV QEYKVWCLGN ETRYHINKTV DGSTFSVVIP
FLVPGIRYSV EVAASTGAGP GVKSEPQFIQ LDSHGNPVSP EDQVSLAQQI SDVVKQPAFI
AGIGAACWII LMLFSVWLYR HRKKRNGLTS TYAGIRKVTY QRGGEAVSSG GRPGLLNISE
PTTQPWLADT WPNTGNNHND CSISCCAAGN GNSDSNLTTY SRPADCIANY NNQLDNKQTN
LMLPESTVYG DVDLSNKINE MKTFNSPNLK DGRFVNPSGQ PTPYATTQLI QPNLSNNMNS
GSGDSGEKHW KPLGQQKPEV APVQYNIMEQ NKLNKDYRAN DTIPPTIPYN QSYDQNTGGS
YNSSDRGSST SGSQGHKKGA RTPKVPKQGG MNWADLLPPP PAHPPPHSNS EEYNISVDES
YDQEMPCPVP PARMYLQQDE LEEEEDERGP TPPVRGAASS PAAVSYSHQS TATLTPSPQE
ELQPMLQDCP EEIGHMQHQP DRRRQPVSPP PPPRPISPPH TYGYISGPLV SDMDTDAPEE
EEDEADMEVA KMQTRRLLLR GLEQTPASSV GDLESSVTGS MINGWGSASE EDNISSGRSS
VSSSDGSFFT DADFAQAVAA AAEYAGLKVA RRQMQDAAGR RHFHASQCPR PTSPVSTDSN
MSAAVMQKTR PAKKQKHQPG HLRREAYTDD LPPPPVPPPA IKSPTVPSKT QLEVRPVVVP
KLPSIDARTD RSSDRKGSNY KGRDMLDGRQ VVDMRTNPGD PREAQEQQND GKGRGNKAAK
RDLPPAKTHL IQEDILPYCR PTFPTSNNPR DPSSSSSMSS RGSGSRQREQ ANVGRRNIAE
MQVLAGYERG EDNNEELEET ES
//
