ID U3E630_CALJA Unreviewed; 488 AA.
AC U3E630; F6RH78; F7I7B0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Protein kinase C and casein kinase substrate in neurons 2 {ECO:0000313|Ensembl:ENSCJAP00000042066.3};
DE SubName: Full=Protein kinase C and casein kinase substrate in neurons protein 2 isoform A {ECO:0000313|EMBL:JAB46383.1};
GN Name=PACSIN2 {ECO:0000313|EMBL:JAB46383.1,
GN ECO:0000313|Ensembl:ENSCJAP00000042066.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB46383.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000042066.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB46383.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebellum {ECO:0000313|EMBL:JAB46383.1}, and Hippocampus
RC {ECO:0000313|EMBL:JAB12584.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000042066.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection,
CC ruffle membrane {ECO:0000256|ARBA:ARBA00004599}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004599}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004599}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Early endosome
CC {ECO:0000256|ARBA:ARBA00004412}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane, caveola
CC {ECO:0000256|ARBA:ARBA00004345}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004565}.
CC -!- SIMILARITY: Belongs to the PACSIN family.
CC {ECO:0000256|ARBA:ARBA00010461}.
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DR EMBL; GAMS01010552; JAB12584.1; -; mRNA.
DR EMBL; GAMP01006372; JAB46383.1; -; mRNA.
DR RefSeq; XP_017819469.1; XM_017963980.1.
DR STRING; 9483.ENSCJAP00000042066; -.
DR Ensembl; ENSCJAT00000056111.4; ENSCJAP00000042066.3; ENSCJAG00000009771.5.
DR GeneTree; ENSGT00950000182973; -.
DR HOGENOM; CLU_030752_0_0_1; -.
DR OrthoDB; 9421at2759; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000009771; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0070836; P:caveola assembly; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0097320; P:plasma membrane tubulation; IEA:InterPro.
DR CDD; cd07679; F-BAR_PACSIN2; 1.
DR CDD; cd11998; SH3_PACSIN1-2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR035743; PACSIN1/PACSIN2_SH3.
DR InterPro; IPR037453; PACSIN2_F-BAR.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF14; PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 2; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Kinase {ECO:0000313|EMBL:JAB46383.1};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000313|EMBL:JAB46383.1}.
FT DOMAIN 11..282
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 428..488
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 316..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 488 AA; 56067 MW; B1997CE9B77D11D2 CRC64;
MSVAYDDSIG VEVSSDSFWE VGNYKRTVKR IDDGHRLCTD LMNCLHERAR IEKAYAQQLT
EWARRWRQLV EKGPQYGTVE KAWTAVMSEA ERVSELHLEV KASLMNEDFE KIKNWQKEAF
HKQMMGGFKE TKEAEDGFRK AQKPWAKKLK EVEAAKKAHH AACKEEKLAI SREANSKADP
SLNPEQLKKL QDKVEKCKQD VLKTKEKYEK SLKELDQGTP QYMENMEQVF EQCQQFEEKR
LRFFREVLLE VQKHLDLSNV AGYKTIYRDL EQSIRAADAV EDLRWFRANH GPGMAMNWPQ
FEDEEWSADL NRTLSRREKK KATDGVTLTG INQTGDQSLP NKPSSTLNVP SNPAQSAQSQ
SSYNPFEDED DTGSTVSEKE DTKAKNVSSY EKTQSYPTDW SDDESNNPFS STDANGDSNP
FDEDTTSGME VRVRALYDYE GQEHDELSFK AGDELTKMED EDEQGWCKGR LDNGQVGLYP
ANYVEAIQ
//
