ID U3F271_CALJA Unreviewed; 4366 AA.
AC U3F271;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Ankyrin-3 isoform 1 {ECO:0000313|EMBL:JAB32631.1};
GN Name=ANK3 {ECO:0000313|EMBL:JAB32631.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB32631.1};
RN [1] {ECO:0000313|EMBL:JAB32631.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebral cortex {ECO:0000313|EMBL:JAB32631.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; GAMR01001301; JAB32631.1; -; mRNA.
DR EMBL; GAMR01001300; JAB32632.1; -; mRNA.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08803; Death_ank3; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR037971; Ank3_Death.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 7.
DR Pfam; PF13637; Ank_4; 3.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 22.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 73..105
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 106..138
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 139..171
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 172..195
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 234..266
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 267..299
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 300..332
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 333..365
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 366..398
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 399..431
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 432..464
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 465..497
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 498..530
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 531..563
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 564..596
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 597..629
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 630..662
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 663..695
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 696..728
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 729..761
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 762..794
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 984..1139
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1141..1288
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 4079..4163
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1512..1533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1961..2008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2100..2149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2169..2257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2293..2317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2371..2426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2467..2501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2585..2743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2789..2822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3029..3059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3125..3264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3290..3509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3531..3608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3628..3712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3861..3892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3921..3972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4008..4080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4248..4267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4313..4366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1961..1995
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2105..2122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2123..2139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2212..2241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2303..2317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2396..2426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2585..2611
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2612..2629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2662..2716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2717..2741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3034..3051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3125..3178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3217..3235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3326..3348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3371..3398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3455..3488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3538..3562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3569..3592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3643..3709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3875..3892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3948..3972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4008..4023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4024..4041
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4042..4066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4327..4355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4366 AA; 479078 MW; E11710BF87B12F8D CRC64;
MAHAASQLKK TRDLEINAEE EPEKKRKHRK RSRDRKKKSD ANASYLRAAR AGHLEKALDY
IKNGVDINIC NQNGLNALHL ASKEGHVEVV SELLQREANV DAATKKGNTA LHIASLAGQA
EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE NHLEVVKFLL DNGASQSLAT EDGFTPLAVA
LQQGHDQVVS LLLENDTKGK VRLPALHIAA RKDDTKAAAL LLQNDNNADV ESKSGFTPLH
IAAHYGNINV ATLLLNRAAA VDFTARNDIT PLHVASKRGN ANMVKLLLDR GAKIDAKTRD
GLTPLHCGAR SGHEQVVEML LDRAAPILSK TKNGLSPLHM ATQGDHLNCV QLLLQHNVPV
DDVTNDYLTA LHVAAHCGHY KVAKVLLDKK ANPNAKALNG FTPLHIACKK NRIKVMELLL
KHGASIQAVT ESGLTPIHVA AFMGHVNIVS QLMHHGASPN TTNVRGETAL HMAARSGQAE
VVRYLVQDGA QVEAKAKDDQ TPLHISARLG KADIVQQLLQ QGASPNAATT SGYTPLHLSA
REGHEDVAAF LLDHGASLSI TTKKGFTPLH VAAKYGKLEV ANLLLQKSAS PDAAGKSGLT
PLHVAAHYDN QKVALLLLDQ GASPHAAAKN GYTPLHIAAK KNQMDIATTL LEYGADANAV
TRQGIASVHL AAQEGHVDMV SLLLGRNANV NLSNKSGLTP LHLAAQEDRV NVAEVLVNQG
AHVDAQTKMG YTPLHVGCHY GNIKIVNFLL QHSAKVNAKT KNGYTPLHQA AQQGHTHIIN
VLLQNNASPN ELTVNGNTAL GIARRLGYIS VVDTLKVVTE ETMTTTTVTE KHKMNVPETM
NEVLDMSDDE VRKANAPEML SDGEYISDVE EGEDAMTGDT DKYLGPQDLK ELGDDSLPAE
GYMGFSLGAR SASLRSFSSD RSYTLNRSSY ARDSMMIEEL LVPSKEQHLT FTREFDSDSL
RHYSWAADTL DNVNLVSSPI HSGFLVSFMV DARGGSMRGS RHHGMRIIIP PRKCTAPTRI
TCRLVKRHKL ANPPPMVEGE GLASRLVEMG PAGAQFLGPV IVEIPHFGSM RGKERELIVL
RSENGETWKE HQFDSKNEDL TELLNGMDEE LDSPEELGKK RICRIITKDF PQYFAVVSRI
KQESNQIGPE GGILSSTTVP LVQASFPEGA LTKRIRVGLQ AQPVPDEIVK KILGNKATFS
PIVTVEPRRR KFHKPITMTI PVPPPSGEGV SNGYKGDTTP NLRLLCSITG GTSPAQWEDI
TGTTPLTFIK DCVSFTTNVS ARFWLADCHQ VLETVGLATQ LYRELICVPY MAKFVVFAKM
NDPVESSLRC FCMTDDKVDK TLEQQENFEE VARSKDIEVL EGKPIYVDCY GNLAPLTKGG
QQLVFNFYAF KENRLPFSIK IRDTSQEPCG RLSFLKEPKT TKGLPQTAVC NLNITLPAHK
KIEKTDRRQS FASLALRKRY SYLTEPGMKT VERSTGATRS PPPTYSYKPF FSTRPYQSWT
TAPITVPGPA KSGFTSLSSS SSNTPSASPL KSIWSVSTPS PIKSTLGAST TSSVKSISDV
ASPIRSFRTM SSPIKTVVSQ SPYNIQVSSG TLARAPAVTE ATPLKGLASN STFSSRTSPV
TTAGSLLERS SITMTPPASP KSNINMYSSS LPFKSIITSA APLMSSPLKS VVSPVKSAVD
AISSAKVTMA SSLSSPVKQM PGHAEVALVN GSISPLKYPS SSTLINGCKA TATLQETIST
ATNSVSSVVN AATDTVEKAF STTTAMPFSP LRSYVSAAPS AFQSLRTPSA SALYTSLGSS
ISATTSSVTS SIITVPVYSV VNVLSEPALK KLPDSNSFTK SAAALLSPIK TLTTETRPQP
HFNRTSSPVK SSLFLAPSAL KLSTPSSLSS SQEILKDVAE MKEDLMRMTA ILQTDVPEEK
PFQPELPKEG RIDDEEPFKI VEKVKEDLVK VSEILKKDVC VDNKGSPKSP KSDKGHSPED
DWTEFSSEEI REARQQAAAS HSPTLPERVQ VKAKAASEKD YNLTKVIDYL TNDIGSSSLT
NLKYKFEDAK KDGEERQKRV LKPAIALQEH KLKMPPASMR PSTSEKELCK MADSFFGTDT
ILESPDDFSQ HDQDKSPLSD SGFETRSEKT PSAPQSAEST GPKPLFHEVP IPPVITETRT
EVVHVIRSYE PSAGDVPQTQ PEEPVSPKPS PTFMELEPKP TTSSIKEKVK AFQMKASSEE
DDHNRVLSKG MRVKEETHIT TTTRMVYHSP PGGEGTSERI EETMSVHDIM KAFQSGRDPS
KELAGLFEHK SAVPPDVHKS AAETSAQHAE KDNQMKPKLE RIIEVHIEKG NQAEPTEVII
RETKKHPEKE MYVYQKDLSR GDINLKDFLP EKHDAFPCSE EQGQQEEEEL TAEESLPSYL
ESSRVNTPVS QEEDSRPSSA QLISDDSYKT LKLLSQHSIE YHDDELSELR GESYRFAEKM
LLSEKLDVSH SDTEESVTDH AGPPSSELQG SDKRSREKVA TAPKKEILSK IYKDVSENGV
GKVSKDEHFD KVTVLHYSGN VSSPKHAMWM RFTEDRLDRG REKLIYEDRV DRTVKEAEEK
LTEVSQFFRD KTEKLNDELQ SPEKKARPKN GKEYSSQSST SSSPEKVLLT ELLASNDEWV
KARQHGPDGQ GFPKAEEKAS SLPSSPEKTA LSQQTEDSKS TVEAKGSISQ SKAPDGPQSG
FQLKQSKLSS IRLKFEQGTH TKSKDMSQED RKSDGQSRIP VKKIQESKLP VYQVFAREKQ
QKAIDLPDES VSVQKDFMVL KAKDEHAQSN EIVVNDSGSD NVKKQRTEMS SKAMPDSFSE
QQAKDLACHI TSDLATRGPW DKKVFRTWES SGATNNKCQK EKLSHVLVHD VRENHIGHPE
SKSVDQKNEF MSVTEREHKL LTNGSLSEIK EMTVKSPSKK VLYREYVVKE GDRPAGLLDQ
PSRRSESSAV SHIPVRVADE RRMLSSNIPD GFCEQSAFPK HELSQKLSQS SMSKETVETQ
HFNSIEDEKV TYSEISKVSK HQSYVGLCPP LEETETSPTK SPDSLEFSPG RESPSSDVFD
HSPIDGLEKL APLAQTEGGK EIKTLPVYVS FVQVGKQYEK EIQQGSLKKI ISQECKTVQE
TRGTFYTTRQ QKQPPSPQGS PEDDTLEQVS FLDSSGKSPL TPETPSSEEV SYEFTSKTPD
SLIAYIPGKP SPIPEVSEES EEEEQAKSAS LKQATVEEIA VKREMPNDMS KDSNQRPKSN
RVAYIEFPPP PPLDADQIES DKRHHYLPEK EVDMIEVNLQ DEHDKYQLAE PVIRVQPPSP
VPPGADVSDS SDDESIYQPV PVKKYTFKLK EVDDEQKEKP KASAEKASTQ KELESNGSGK
DNEFGLGLDA PQNETAQNGN NDQSITECSI ATTAEFSHDT DATEIDSLDG YDLQDEDDGL
TESDSKLPSQ AMEIKKDIWN TEGILKPADR SFSQSKLEVI EEEEKVGPDE DKPPSKSSAS
EKTPDKTDQK SGAQFFTLEG RHPDRSVFPD TYFSYKVDEE FATPFKTVAT KGLDFDPWSS
NRGDDEVFDS KSREDETKPF GLAVEDRSPA TTPDTTPART PTDESTPTSE PNPFPFHEGK
MFEMTRSGAI DMSKRDFVEE RLQFFQIGEH TSEGKSGDQG EGDKSMVTAT PQPQSGDTTV
ETNLERNVET PTVEPDPSSP TSGECQEGTS SSGPLEKSAA ATNTSKVDPK LRTPIKMGIS
ASTMTMKKEG PGEITDKIEA VMTSCQGLEN ETITVISNAA NSQTGIRPHE KHDFQKDNFN
NNNNLDSSTI QTDNMISNIA LTEHSAPTCT TEKDNPVKVS SGKKTGVLQG HCLRDKQKVL
GEQQKTKELI GIRQKSKLPI KATSPKDTFP PNHLPNIKAS KTKQVSQSEK TKGLTTSSCV
DVKSRIPVKN THRDNIVAVR KARATQKQGQ PEKGKAKQLP SKLPVKVRPT CVTTTTTSTS
TSTTTTSTST VKVRKSQLKE VCKHSIEYFK GISGETLKLV DRLSEEEKKM QSELSDEEES
TSRNTSLSET SRGGQPSVTS KSARDKKTEA APLKSKSEKA GSEKRSSRRT GPQSPCERTD
IRMAIVADHL GLSWTELARE LNFSVDEINQ IRVENPNSLI SQSFMLLKKW VTRDGKNATT
DALTAVLTKI NRIDIVTLLE GPIFDYGNIS GTRSFADENN VFHDPVDGWQ NETSSGNLES
PAQARRITGG LLDRLDDSPD QCRDSITSYL KGETGKFEAN GSHTEITPEA KTKPYFPESQ
NDIGKQNTKE TLKPKIHGSG HVEEPASPLA AYQKSLEEAS KLVIEETKPC VPVSMKKMSR
TSPPDGKPRL NLHEEEGSSG SEQKQGEVFK VKAKKEIRHV EKKSHS
//
