ID U3FS43_CALJA Unreviewed; 1196 AA.
AC U3FS43; F6ZER4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Neuronal cell adhesion molecule {ECO:0000313|EMBL:JAB49881.1, ECO:0000313|Ensembl:ENSCJAP00000051959.4};
GN Name=NRCAM {ECO:0000313|EMBL:JAB49881.1,
GN ECO:0000313|Ensembl:ENSCJAP00000051959.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB49881.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000051959.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB49881.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebellum {ECO:0000313|EMBL:JAB49881.1}, and Hippocampus
RC {ECO:0000313|EMBL:JAB21907.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000051959.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GAMS01001229; JAB21907.1; -; mRNA.
DR EMBL; GAMP01002874; JAB49881.1; -; mRNA.
DR Ensembl; ENSCJAT00000054490.4; ENSCJAP00000051959.4; ENSCJAG00000016572.5.
DR GeneTree; ENSGT00940000155419; -.
DR HOGENOM; CLU_005756_2_0_1; -.
DR OrthoDB; 2912783at2759; -.
DR Proteomes; UP000008225; Chromosome 8.
DR Bgee; ENSCJAG00000016572; Expressed in frontal cortex and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05868; Ig4_NrCAM; 1.
DR CDD; cd05874; IgI_NrCAM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF15; NEURONAL CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 2: Evidence at transcript level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1196
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010152791"
FT TRANSMEM 1061..1082
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..128
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 135..229
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 261..350
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 355..442
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 448..535
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 539..626
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 643..738
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 740..837
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 842..944
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 948..1045
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1091..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1196 AA; 132289 MW; 921134F0D39AF4FF CRC64;
MQLKIMPKKK RLSAGRVPLI LFLCQMISAL EVPLDLVQPP TITQQSPKDY IIDPRENIVI
QCEAKGKPPP SFSWTRNGTH FDIDKDALVT MKPGTGTLII NIMSEGKAET YEGVYQCTAR
NERGAAISNN IVVRPSRSPL WTKEKLEPIT LQNGQSLVLP CRPPIGLPPP IIFWMDNSFQ
RLPQSERVSQ GLNGDLYFSN VLPEDTREDY ICYARFNHTQ TIQQKQPISV KVISVDELND
TIAANLSDTE FYGAKSNRER PPTFLTPEGN ASNKEELRGN VLLLECIAEG LPTPLIYWAK
EDGILPTNRT SYKNFKKTLQ ITHVSEADSG NYQCIAKNAL GAIHHTISVR VKAAPYWIMA
PQNLVLSPGE DGTLICRANG NPKPRISWLT NGVPIEIAPD DPSRKIDGDT IIFSNVQERS
SAVYQCNASN EYGYLLANAF VNVLAEPPRI LTPANTLYQV IANRPALLDC AFFGSPLPTI
EWFKGAKGSA LHEDIYVLHE NGTLEIPVAQ KDSTGTYTCV ARNKLGMAKN DVHLEIKDPT
WIIKQPEYAV VQRGGMVSFE CKVKHDHTLV LTVLWLKDNE ELPSDERFTV DKDHLVVADV
SDDDSGTYTC VANTTLDSVS ASAVLSVVAP TPTPVPVYDV PNPPFDLELT DQLDKSVQLS
WTPGDDNNSP ITKFIIEYED AMHEPGLWHH QTEVSGTQTT AQLKLSPYVN YSFRVTAVNS
IGKSLPSEAS EQYLTKASEP DKNPTAVEGL GSEPDNLVIT WKPLNGFESN GPGLQYKVSW
RQKDGDDEWT SVVVANVSKY IVSGTPTFVP YLIKVQALND VGFAPEPAVV MGHSGEDLPM
VAPGNVQVNV VNSTLAEVHW DPVPLKSIRG HLQGYRIYYW KTQNSPKRNR RHIEKKILTF
QGSKTHGMLP GLEPFSHYTL NVRVVNGKGE GPASPDKVFN TPEGVPSAPS SLKIVNPTLD
SLTLEWDPPS HPNGILTEYT LKYQPINSTH ELGPLVDLKI PANKTRWTLK NLNFSTRYKF
YFYAQTSAGS GSQITEEAVT TVDEGKMAMA SRQVDIATQG WFIGLMCAVA LLILILLIVC
FIRRNKGGKY PVKEKEDAHA DPEIQPMKED DGTFGEYSDA EDHKPLKKGS RTPSDRTVKK
EDSDDSLVDY GEGVNGQFNE DGSFIGQYSG KKEKEPAEGN ESSEAPSPVN AMNSFV
//
