ID U3JC40_FICAL Unreviewed; 504 AA.
AC U3JC40;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Centrosomal protein 57 {ECO:0000313|Ensembl:ENSFALP00000000344.1};
GN Name=CEP57 {ECO:0000313|Ensembl:ENSFALP00000000344.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000000344.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000000344.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000000344.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the translokin family.
CC {ECO:0000256|ARBA:ARBA00008179}.
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DR RefSeq; XP_005038246.1; XM_005038189.2.
DR AlphaFoldDB; U3JC40; -.
DR STRING; 59894.ENSFALP00000000344; -.
DR Ensembl; ENSFALT00000000347.2; ENSFALP00000000344.1; ENSFALG00000000337.2.
DR GeneID; 101818088; -.
DR KEGG; fab:101818088; -.
DR CTD; 9702; -.
DR eggNOG; ENOG502QTZR; Eukaryota.
DR GeneTree; ENSGT00530000063695; -.
DR HOGENOM; CLU_034321_2_0_1; -.
DR OMA; DLQRSPW; -.
DR OrthoDB; 5396442at2759; -.
DR Proteomes; UP000016665; Chromosome 1.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0017134; F:fibroblast growth factor binding; IEA:Ensembl.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR PANTHER; PTHR19336:SF11; CENTROSOMAL PROTEIN OF 57 KDA; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 69..245
FT /note="Cep57 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14073"
FT DOMAIN 355..423
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 250..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 67..147
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 183..231
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 331..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 504 AA; 57784 MW; 13E0B8A706B76B40 CRC64;
MADMATAAAE CCHRYTDDLH KTQNSTSATD GLSSESFIEY PKHKPFINSD LQRSPWKPVI
SYPESNSRAI FSALKNLQEK IHQLELERFQ AEENVKHLSR ETADYKKVLS EQMQRKERDK
TEVSKKNQEL SCQLANAESR CRLLEKQLGY MKKMIRHAES EKSHLLEKQG SLEKDRFLDQ
SHVQSKLEKL DILEKEYSRL NRMQSIAEEK MKELEQKLHE EEHARKLVQE KAAELQTGLE
TNRLLIQAAS PLLSPKARQP RKKAKQPEKK RSLVRHPTVQ PHYRLCLGDV PFVAGKSTSP
SHSVGANVQH VLHLMKHHTK ALCNKHVVND TPLAKPTSTS RPASKSRRPS LPMDSSSSQE
ELSEVLLTLQ DEFGQMSFDH QQLSKLIEEA PTVAVREDLE RELEALVGRM EAKADQIGKV
QKHRFKLERL KRECKSRNTS AKQIKDSRFP VSEVKVTTTI TTKGKNAGPI KVKPGEKSRK
NLQLLRDMQT IQTSLQKDDI SWDY
//
