ID U3JFA8_FICAL Unreviewed; 370 AA.
AC U3JFA8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Hexosyltransferase {ECO:0000256|RuleBase:RU363063};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU363063};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000001462.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000001462.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000001462.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-
CC galactosamine = a globoside Gb4Cer (d18:1(4E)) + H(+) + UDP;
CC Xref=Rhea:RHEA:22252, ChEBI:CHEBI:15378, ChEBI:CHEBI:18259,
CC ChEBI:CHEBI:18313, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138; EC=2.4.1.79;
CC Evidence={ECO:0000256|ARBA:ARBA00043819};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22253;
CC Evidence={ECO:0000256|ARBA:ARBA00043819};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU363063}; Single-pass type II membrane protein
CC {ECO:0000256|RuleBase:RU363063}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 31 family.
CC {ECO:0000256|ARBA:ARBA00008661, ECO:0000256|RuleBase:RU363063}.
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DR AlphaFoldDB; U3JFA8; -.
DR STRING; 59894.ENSFALP00000001462; -.
DR Ensembl; ENSFALT00000001471.2; ENSFALP00000001462.2; ENSFALG00000001402.2.
DR eggNOG; KOG2287; Eukaryota.
DR GeneTree; ENSGT00940000162252; -.
DR HOGENOM; CLU_036849_2_4_1; -.
DR Proteomes; UP000016665; Chromosome 9.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0047273; F:galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity; IEA:RHEA.
DR GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR Gene3D; 3.90.550.50; -; 1.
DR InterPro; IPR002659; Glyco_trans_31.
DR PANTHER; PTHR11214; BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11214:SF153; UDP-GALNAC:BETA-1,3-N-ACETYLGALACTOSAMINYLTRANSFERASE 1; 1.
DR Pfam; PF01762; Galactosyl_T; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU363063};
KW Golgi apparatus {ECO:0000256|RuleBase:RU363063};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REGION 67..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..105
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 370 AA; 41481 MW; E1332DF1D317AB58 CRC64;
GTPAPPDHDS GSDRRPVREA LAVDFPAAAA LFPAHHVVRH PLLQGRPGEP QPALLLRVRA
RLPAGAAVRA ARAPPLRPPP PPPPPPPPPP PPPPPPPPPP PPPPLRERRR CAEARPFLVI
LVASSPGELR ARQAIRVSWG SRGSWWGQRV LTLFLLGRAG RGERGPAALS VEDESVLYGD
IIRQDFLDTY DNLTLKTIMA FQWFSEFCPG ARFFMKTDVD VFINTPNLVK LLLRLNSSEN
VFTGFPLIQN FAYRGFDRKR FISYEEYPFR LYPPYCSGLG YILDGKLALR VYELMGHVKP
LKFEDVYVGI CLNLLKVNVT LPEDAEQYFL YKIDFDICKY RHLIAVHGLT SSELVQFWQD
LSSDTSKTCL
//
