ID   U3JKV5_FICAL            Unreviewed;       694 AA.
AC   U3JKV5;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Acyl-CoA synthetase family member 3 {ECO:0000313|Ensembl:ENSFALP00000003409.2};
GN   Name=ACSF3 {ECO:0000313|Ensembl:ENSFALP00000003409.2};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000003409.2, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000003409.2, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000003409.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   AlphaFoldDB; U3JKV5; -.
DR   STRING; 59894.ENSFALP00000003409; -.
DR   Ensembl; ENSFALT00000003423.2; ENSFALP00000003409.2; ENSFALG00000003262.2.
DR   eggNOG; KOG1176; Eukaryota.
DR   GeneTree; ENSGT00940000157000; -.
DR   HOGENOM; CLU_000022_59_11_1; -.
DR   OrthoDB; 5473537at2759; -.
DR   Proteomes; UP000016665; Chromosome 11.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0090409; F:malonyl-CoA synthetase activity; IEA:Ensembl.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0031957; F:very long-chain fatty acid-CoA ligase activity; IEA:Ensembl.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0090410; P:malonate catabolic process; IEA:Ensembl.
DR   CDD; cd05941; MCS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43201; ACYL-COA SYNTHETASE; 1.
DR   PANTHER; PTHR43201:SF8; FATTY ACID COA SYNTHETASE FAMILY; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT   DOMAIN          165..555
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          606..681
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
FT   REGION          1..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..42
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   694 AA;  75989 MW;  77D293977B30793B CRC64;
     MTSEDTGDTP GGCRDTRPRR APASPPPRGP PPPPPASPPP RGRFGAKSPQ TRRGAAERSC
     AERSRRGAAF PPELRAAGAV PPAAGEAWRR RGSRGSGFLL ISALGCASHL SAGRMLLPLL
     FPQRCRPLRR LLRGLWDGRR AGCPRRALHT AWATCSSDIT PVFTRALAFG DKVAIVDQHG
     EHTYRELLGR SLRLSREICG LLECPSRDLR EERISFLCPN DASYVVAQWA SWLSGGVAVP
     LYRKHPVAQL EYVIQDSQSA LLIAAQEFLG KITPSAKRLG VPVLPLPRSG GDGPTSSAAL
     EEGSLPSCSS WEDRGAMIIY TSGTTGRPKG VLSTHRNVQA VTTGLVEKWE WKKEDVILHV
     LPLHHVHGVI NKLLCPLWVG ATCIMFPEFS AHTVWKKLLS TQAPRVSVFM AVPTIYAKLV
     EYYDEHFTQP QVQDFVRAFC QENIRLMVSG SAALPVPVLE KWKSITGHTL LERYGMTEIG
     MALSNPLHGV RVPGSVGSPL PGVEVCIASE TFGGGARSYA VHARGDENGT QVTPGLEGQE
     GELLVKGPSV FREYWNRPEE TAAAFTPDGW FRTGDTAAYK DGVYWIKGRT SVDIIKNGGF
     KISALEVERQ LLTHPHITDV AVLGAPDVVW GQRVSAVVQL RRGEMLSVRD LRDWARDTMA
     PYAIPTELIV VEEIPRNQMG KVNKKELLKR FYPA
//