ID U3JQ08_FICAL Unreviewed; 482 AA.
AC U3JQ08;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=PAT complex subunit CCDC47 {ECO:0000256|ARBA:ARBA00034875};
DE AltName: Full=Coiled-coil domain-containing protein 47 {ECO:0000256|ARBA:ARBA00034902};
GN Name=CCDC47 {ECO:0000313|Ensembl:ENSFALP00000004862.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000004862.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000004862.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000004862.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Rough endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00034697}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00034697}.
CC -!- SIMILARITY: Belongs to the CCDC47 family.
CC {ECO:0000256|ARBA:ARBA00034746}.
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DR RefSeq; XP_005059919.1; XM_005059862.1.
DR RefSeq; XP_005059920.1; XM_005059863.2.
DR AlphaFoldDB; U3JQ08; -.
DR STRING; 59894.ENSFALP00000004862; -.
DR Ensembl; ENSFALT00000004886.2; ENSFALP00000004862.2; ENSFALG00000004656.2.
DR GeneID; 101816328; -.
DR KEGG; fab:101816328; -.
DR CTD; 57003; -.
DR eggNOG; KOG2357; Eukaryota.
DR GeneTree; ENSGT00390000013997; -.
DR HOGENOM; CLU_033196_1_0_1; -.
DR Proteomes; UP000016665; Chromosome 27.
DR GO; GO:0160064; C:multi-pass translocon complex; IEA:Ensembl.
DR GO; GO:0101031; C:protein folding chaperone complex; IEA:Ensembl.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0044183; F:protein folding chaperone; IEA:Ensembl.
DR GO; GO:0043022; F:ribosome binding; IEA:Ensembl.
DR GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0006983; P:ER overload response; IEA:Ensembl.
DR GO; GO:0160063; P:multi-pass transmembrane protein insertion into ER membrane; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:Ensembl.
DR InterPro; IPR012879; CCDC47.
DR PANTHER; PTHR12883; ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR12883:SF0; PAT COMPLEX SUBUNIT CCDC47; 1.
DR Pfam; PF07946; CCDC47; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..482
FT /note="PAT complex subunit CCDC47"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5032981133"
FT REGION 45..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..104
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 482 AA; 55761 MW; 2690278B3C48F4C5 CRC64;
MKNLYIFIAV LFIPWSFSLA KYDEFEDGDD IMEYDDNDFA EFEDVSEDTV TESPQRVITT
EDDEEEATVE LEGQDENQED FDDADTQEGD TESEPYDDEE FEGYEEKPDA SHSKNKDPIT
IVNVPAHLQN SWESYYMEIL MVTGLLAYIM NYIIGKNKNN RLAHAWFNTH RELLESNFAL
VGDDGTSKEA TSTGKLNQEN EHIYNLWCSG RVCCEGMLIQ LKFLKRQDLL NVLARMMRPA
SDQVQIKVTM NDEDMDTYVF AVGTRKALVR LQKEMQDLSE FCSDKPKSGA KYGLPDSLAI
LSEMGEVTEG MMDAKMIHFL THYADKIDSV QFSDQFSGPK LMQEEGQLTK LPETKKTLLF
TFNVPGSGNT SPKDMESLLP LMSMVIYSID KAKKFRLNRE GKQKADKNRA RVEENFLKLT
HVQRQEAAQS RREEKKRAEK ERIMNEEDPE KQRRLEEAAL RREQKKLEKK QMKMKQIKVK
AM
//
