ID U3JST3_FICAL Unreviewed; 3011 AA.
AC U3JST3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=CHD7 {ECO:0000313|Ensembl:ENSFALP00000005837.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000005837.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000005837.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000005837.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR RefSeq; XP_016152254.1; XM_016296768.1.
DR STRING; 59894.ENSFALP00000005837; -.
DR Ensembl; ENSFALT00000005864.2; ENSFALP00000005837.2; ENSFALG00000005570.2.
DR GeneID; 101810226; -.
DR CTD; 55636; -.
DR eggNOG; KOG0384; Eukaryota.
DR GeneTree; ENSGT00940000153649; -.
DR HOGENOM; CLU_000315_5_0_1; -.
DR OrthoDB; 22878at2759; -.
DR Proteomes; UP000016665; Chromosome 2.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0007512; P:adult heart development; IEA:Ensembl.
DR GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR GO; GO:0035909; P:aorta morphogenesis; IEA:Ensembl.
DR GO; GO:0036302; P:atrioventricular canal development; IEA:Ensembl.
DR GO; GO:0008015; P:blood circulation; IEA:Ensembl.
DR GO; GO:0001974; P:blood vessel remodeling; IEA:Ensembl.
DR GO; GO:0060411; P:cardiac septum morphogenesis; IEA:Ensembl.
DR GO; GO:0050890; P:cognition; IEA:Ensembl.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
DR GO; GO:0060429; P:epithelium development; IEA:Ensembl.
DR GO; GO:0060324; P:face development; IEA:Ensembl.
DR GO; GO:0030540; P:female genitalia development; IEA:Ensembl.
DR GO; GO:0060384; P:innervation; IEA:Ensembl.
DR GO; GO:0043584; P:nose development; IEA:Ensembl.
DR GO; GO:0042048; P:olfactory behavior; IEA:Ensembl.
DR GO; GO:0021772; P:olfactory bulb development; IEA:Ensembl.
DR GO; GO:0021553; P:olfactory nerve development; IEA:Ensembl.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0060123; P:regulation of growth hormone secretion; IEA:Ensembl.
DR GO; GO:0050767; P:regulation of neurogenesis; IEA:Ensembl.
DR GO; GO:0010880; P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR GO; GO:0003226; P:right ventricular compact myocardium morphogenesis; IEA:Ensembl.
DR GO; GO:0062009; P:secondary palate development; IEA:Ensembl.
DR GO; GO:0048752; P:semicircular canal morphogenesis; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR GO; GO:0030217; P:T cell differentiation; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IEA:Ensembl.
DR CDD; cd18668; CD1_tandem_CHD5-9_like; 1.
DR CDD; cd18663; CD2_tandem_CHD5-9_like; 1.
DR CDD; cd18059; DEXHc_CHD7; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 3.40.5.120; -; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR006576; BRK_domain.
DR InterPro; IPR037259; BRK_sf.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR46850; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9; 1.
DR PANTHER; PTHR46850:SF3; DNA HELICASE; 1.
DR Pfam; PF07533; BRK; 2.
DR Pfam; PF00385; Chromo; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00592; BRK; 2.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF160481; BRK domain-like; 2.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50013; CHROMO_2; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 801..868
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 883..948
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 981..1155
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1295..1465
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 94..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1577..1602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1838..1864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2148..2291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2825..2900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2948..3011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..420
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..541
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1577..1600
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2148..2169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2170..2240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2258..2276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2277..2291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2840..2864
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2865..2900
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2950..2984
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2987..3011
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3011 AA; 338104 MW; 7E76A8BF8FFC44DB CRC64;
MADPGMMSLF GEDGNIFSEG LEGLGECGYP ENTVNPMGQQ MPMDQGFPAL QSSLHHPPAN
QNQAKLTHFD HYNQYEQQKM HLMDQPNRMI SNAPGNGIAS PHSQYHNPPV PQVPHSSAAG
GQMGVYPGMQ NERHGQPFVD SGSMWGPRAV QVPDQIRAPY QQQQQQQPQP TQPPQAPSGP
PGQGHPQHMQ QMGNYMARGD FSMQQHGQPQ QQRMNQFSQG QEGLNQGNPF IATSGPGHLS
HVPQQNPSMA PSLRHSVQQF HHHPPTALHG ESVAHSPRFS PNPPQQGAVR PQTLNFSSRS
QTVPSPTINN SGQYSRYPYS NLNQGLVNNT GMNQNLGLTN NTPMNQSVPR YPNAVGFPSN
SGQGLMHQQP IHPSGSLNQM NTQTMHPSQP QGTYASPPPM SPMKAMSNPA GTPPPQVRPG
SAGMPMEVGS YPNIPHPQPS HQPPGAMGIG QRNMGPRNMQ QNRPFMGMSS TPREMGGHMR
PNGCPGVGLA DPQAIQERLI SGQQLPSQQQ SFQQQMPTCP PMQPHPGIHH QSSPPPHPHH
QPWAQLHQSP QNTPQKVPVL QHSPSEPFLE KPVPDMTQVS GPNTQLVKSD DYLPSIEPQP
QQKKKKKKNN HIAAEGPSKG FGKEDFPGGL DSQNLSRNSV DCSQEDKKKK KKPKAKKEPK
DPKEPKEKKE PKTPKVPKTP KEPKEKKAKN TTPKPKTSKK ASKKQDSEAG AGKKKVNKGK
EGSENSDLEK TPPPSPHPED EDDPGVQKRR SSRQVKRKRY TEDLEFKISD EEADDADAAG
RDSPSNTSQS EQQESADAEG PIVEKIMSSR LVKKKMENGE EVEVEEFYVK YKNFSYLHCQ
WASVEELDKD KRIQQKIKRF KAKQGQNKFL SEIDDELFNP DYVEVDRIMD FSRSTDDNGE
PVTHYLVKWC SLPYEDSTWE LKQDIDQAKI EEFEKLMSRE PEMERVERPP ADDWKKSESS
REYKNNNKLR EYQLEGVNWL LFNWYNTRNC ILADEMGLGK TIQSITFLYE IYLKGIHGPF
LVIAPLSTIP NWEREFRTWT ELNVVVYHGS QASRRTIQLY EMYFKDPQGR VIKGSYKFHA
IITTFEMILT DCPELRNIPW RCVVIDEAHR LKNRNCKLLE GLKMMDLEHK VLLTGTPLQN
TVEELFSLLH FLEPGRFPSE TTFMQEFGDL KTEEQVQKLQ AILKPMMLRR LKEDVEKNLA
PKEETIIEVE LTNIQKKYYR AILEKNFTFL SKGGGQANVP NLLNTMMELR KCCNHPYLIN
GAEEKILEEF KETHNADSPD FQLQAMIQAA GKLVLIDKLL PKLKAGGHRV LIFSQMVRCL
DILEDYLIQR RYPYERIDGR VRGNLRQAAI DRFSRPDSDR FVFLLCTRAG GLGINLTAAD
TCIIFDSDWN PQNDLQAQAR CHRIGQSKSV KIYRLITRNS YEREMFDKAS LKLGLDKAVL
QSMSGRENAT NGVQQLSKKE IEDLLRKGAY GALMDEEDEG SKFCEEDIDQ ILLRRTHTIT
IESEGKGSTF AKASFVASGN RTDISLDDPN FWQKWAKKAE LDIDALNGRN NLVIDTPRVR
KQTRLYSAVK EDELMEFSDL ESDSEEKPTT KPRRPQDKSQ GYARSECFRV EKNLLVYGWG
RWTDILSHGR YKRQLTEQDV ETICRTILVY CLNHYKGDEN IKSFIWDLIT PTADGQTRAL
VNHSGLSAPV PRGRKGKKVK AQSSQPMLQD ADWLTTCNPD VLFQEDSYRK HLKHHCNKVL
LRVRMLYYLR QEVIGDQADK ILEGADSSEV DIWIPEPFHA EVPADWWDKE ADKSLLIGVF
KHGYEKYNSM RADSTLCFLE RVGMPDAKAI AAEQRGTDML ADGGDGGEFD REDEDPEYKP
TRTPFKDEID EFANSPPEDK EESIELHTNK HSESNAELGQ LYWPNTSTLT TRLRRLITAY
QRSYKRQQMR QEALMKTDRR RRRPREEVRA LEAEREAIIT EKRQKWTRRE EADFYRVVST
FGVIFDPVKH QFEWNQFRAF ARLDKKSDES LEKYFNGFVN MCRRVCRMPV KPDDEPPDLS
TLIEPITEER ASRTLYRIEL LRKIREQVLH HPQLGERLKL CQPSLDLPEW WECGKHDKDL
LIGAAKHGVS RTDYHILNDP ELSFLEAHKN FAQNRGTGSV NTVSSVNPLG AGCSQTPPIV
PSTPVQEEKT TEQTESKVEG SENPAAKEKS EIKEETDTTD KDTKPDCDAE AEPGSVKCEL
KDIEMSTDVD PKSISEKGSE EDEEEKLEDD DKSEESSQPE AGAVSQGKNF DEESIASMST
ARDETRDGFY MEDGDPSVVQ LLHERTFAFS FWPKDRVMIN RLDNICEAVL KGKWPVNRRQ
MFDFQGLIPG YTPTAVDSPL QKRSFAELSM VGQASVSGSE DLTASPQLSK EDALNLSVPR
QRRRRRRKIE IEAERAAKRR NLMEMVAQLR ESQVVSENGQ EKVVDLSKAS REATSSTSNF
SSVTSKFILP NVSTPVSDAF KTQMELLQAG LSRTPTRHLL NGSLIDGEPP MKRRRGRRKN
VEGLDLLFMS NKRTSLTVED AEVTKAFEED MEALPARNIP SPGQLDPDTR IPVINLEDGT
RLVGEDAPKN KDLVEWLKLH PTYTVDMPSY VPKSADVLFS PFQKPKQKRH RCRNPNKLDI
NTLTGEERVP VVNKRNGKKM GGAMAPPMKD LPRWLEENPE FAVAPDWTDI VKQSGFVPES
MFDRLLTGPV VREEGASRRG RRPKSEIAKA AAAAAAVAST SGINPLLMNS LFAGMDLTSL
QNLQNLQSLQ LAGLMGFPPG LATAAAAGGD AKNPAAMLPL MLPGMAGLPN MFGLSGLLNN
PITATTGNAT TASGQGETED GASKAEEKKN ENEEENKDSE KSTDTVSATD SANGSVSAAT
AATTATATTT TTTNTGLPTN PLAFNPFLLS TMAPGLFYPS MFLPPGLGGL TLPGFPALAG
LQNAVGSNEE KATDKTEGAA FKDEENLEGS DAEESLDKTA DSSVLEDEIA QGEELDSLDG
GEEIENNEND E
//
