ID U3JWL8_FICAL Unreviewed; 494 AA.
AC U3JWL8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=RasGEF domain family member 1A {ECO:0000313|Ensembl:ENSFALP00000007172.2};
GN Name=RASGEF1A {ECO:0000313|Ensembl:ENSFALP00000007172.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000007172.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000007172.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000007172.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; U3JWL8; -.
DR Ensembl; ENSFALT00000007204.2; ENSFALP00000007172.2; ENSFALG00000006866.2.
DR eggNOG; KOG3541; Eukaryota.
DR GeneTree; ENSGT00940000160822; -.
DR HOGENOM; CLU_022907_2_0_1; -.
DR OrthoDB; 7992at2759; -.
DR Proteomes; UP000016665; Chromosome 6.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF172; RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1A; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 52..183
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 227..474
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 494 AA; 57115 MW; 6762863AE86148B7 CRC64;
MREKAAEMAA LSCSWVQETM PQTPIFSSML GSSCSGQVQP DMGERCVDPV YQDGNLVSGS
LEALIERLVP TMDYYPDRTY IFTFLLSSRV FIHPHELLAK VGQICIKQKQ QLETGTEAEK
AKLKSFAAKI IQLLKEWTET FPYDFQDEKS MKELKEIAHR ITQCDEENGT VKKIISQMTQ
NLLMALSARS QYQEIREKFR QPVTDKGTIL KTKPQSTQKD ILSVCCDPLI LAQQLTYIEL
ERVSNIYPED LMQIVSHMDS LDNHKCRSDV TKTYNLEAYD NWFNCLSMLV ATEICRVVKK
KQRTRMVEFF IDVARECFNI GNFNSMMAII SGMNLSPVAR LKKTWSKVKT AKFDVLEHHM
DPSSNFCNYR TALQGAAQRS QSANSSREKI VIPVFNLFIK DIYFLHKIHT NRLPNGQINF
KKFWEISRQI HDFLTWKQVE CPFEKDKKIQ TYLLTAPIYS EEALFIASFE SEGPENHMEK
DSWKTLRTTL LNRA
//
