ID U3K176_FICAL Unreviewed; 213 AA.
AC U3K176;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=MORN repeat-containing protein 4 {ECO:0000256|ARBA:ARBA00039855};
GN Name=MORN4 {ECO:0000313|Ensembl:ENSFALP00000008780.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008780.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000008780.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000008780.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in promoting axonal degeneration following
CC neuronal injury by toxic insult or trauma.
CC {ECO:0000256|ARBA:ARBA00037780}.
CC -!- SUBUNIT: Interacts with MYO3A. {ECO:0000256|ARBA:ARBA00038723}.
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium tip
CC {ECO:0000256|ARBA:ARBA00004495}. Cell projection, stereocilium
CC {ECO:0000256|ARBA:ARBA00004645}.
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DR AlphaFoldDB; U3K176; -.
DR STRING; 59894.ENSFALP00000008780; -.
DR Ensembl; ENSFALT00000008818.2; ENSFALP00000008780.2; ENSFALG00000008422.2.
DR eggNOG; KOG0231; Eukaryota.
DR GeneTree; ENSGT00730000111173; -.
DR HOGENOM; CLU_113346_0_0_1; -.
DR OrthoDB; 2909023at2759; -.
DR Proteomes; UP000016665; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0032433; C:filopodium tip; IEA:UniProtKB-SubCell.
DR GO; GO:0032426; C:stereocilium tip; IEA:Ensembl.
DR GO; GO:0048678; P:response to axon injury; IEA:Ensembl.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR InterPro; IPR003409; MORN.
DR PANTHER; PTHR46614; MORN REPEAT-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46614:SF1; MORN REPEAT-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02493; MORN; 4.
DR SMART; SM00698; MORN; 4.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REGION 15..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..44
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 213 AA; 22789 MW; 2D36B9D3507A210D CRC64;
MEIANGEWGW TLAAWHRPAG RGAGRGGGGP PPPPPPPPPP PRRDLVGSGV VEQRGASSCP
AVPEAVAMTL TKGSFTYSSG EEYRGEWKEG RRHGIGQLTF ADGTAYVGHF ENGLFHGCGV
LTFSDGSRYE GEFVQGKFNG VGVFTRCDNM TFEGEFKGGR VYGFGLLTFP DGSHGVPRNE
GFFENNKLLR REKCTAIIQR AQGASKSAHS LTA
//
