ID   U3K1C3_FICAL            Unreviewed;       499 AA.
AC   U3K1C3;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   24-JAN-2024, entry version 49.
DE   SubName: Full=Rho GTPase activating protein 19 {ECO:0000313|Ensembl:ENSFALP00000008827.2};
GN   Name=ARHGAP19 {ECO:0000313|Ensembl:ENSFALP00000008827.2};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008827.2, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000008827.2, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000008827.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; U3K1C3; -.
DR   STRING; 59894.ENSFALP00000008827; -.
DR   Ensembl; ENSFALT00000008865.2; ENSFALP00000008827.2; ENSFALG00000008462.2.
DR   eggNOG; KOG1453; Eukaryota.
DR   GeneTree; ENSGT00940000157331; -.
DR   HOGENOM; CLU_046228_0_0_1; -.
DR   Proteomes; UP000016665; Chromosome 6.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04392; RhoGAP_ARHGAP19; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR047941; ARHGAP19_RhoGAP.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR   PANTHER; PTHR14963:SF7; RHO GTPASE-ACTIVATING PROTEIN 19; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT   DOMAIN          102..308
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          332..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..365
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   499 AA;  56341 MW;  5405F33217AE28FA CRC64;
     MLMQSLKYKF PPPLPVTHSD AICNFVICND SSLRSHPIIF NPDFFVEKLR HEKPEVFTEL
     VVSNITRLID LPGAELAQLM GEEDPKLPGA NSTASGFFRS LMSLKRKEKG VVFGSPLTEE
     GIAQVSQLIE YLHKNLRAEG LFRVPGNSIR QQILKDALNS GTDIDLDSGE FHSNDVATLL
     KMFLGELPEP LLTHKHFHAH LKIADLTLFD EKGNKTSTPD KERQIEALQL LFLILPAPNR
     SLLKLLLDLL YQTAKKQDKN KMSAHNLALM FAPHILWPRN VTANDLQENI TKLNNGVTFM
     IKHSQKLFKA PVYIRECARL HYLGSRAHTS KDDLDLLTSS GSKELQPLKS QKRSRLDSCH
     QEETQQRTEE ALKELFQHVH NMPDSAKKKK LIRQFNKHAT ALTPGSDVPT SPAPRRTRSR
     SFSGLIKRKV LGTPVIMERK SRDTTPEPVR VSKENIQLLQ KCGSPAHMSQ VKLKSLEGQK
     EGSCRRMRAR LLSKDSSSL
//