ID U3K511_FICAL Unreviewed; 1094 AA.
AC U3K511;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=WW and C2 domain containing 1 {ECO:0000313|Ensembl:ENSFALP00000010115.1};
GN Name=WWC1 {ECO:0000313|Ensembl:ENSFALP00000010115.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000010115.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000010115.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000010115.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005053920.1; XM_005053863.1.
DR AlphaFoldDB; U3K511; -.
DR STRING; 59894.ENSFALP00000010115; -.
DR Ensembl; ENSFALT00000010155.2; ENSFALP00000010115.1; ENSFALG00000009702.2.
DR GeneID; 101813975; -.
DR KEGG; fab:101813975; -.
DR CTD; 23286; -.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00410000025556; -.
DR HOGENOM; CLU_005420_0_0_1; -.
DR OMA; QVTVVSM; -.
DR OrthoDB; 1334597at2759; -.
DR Proteomes; UP000016665; Chromosome 13.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0032587; C:ruffle membrane; IEA:Ensembl.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0035331; P:negative regulation of hippo signaling; IEA:Ensembl.
DR GO; GO:0046621; P:negative regulation of organ growth; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR CDD; cd08680; C2_Kibra; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037771; C2_WWC.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14791; BOMB/KIRA PROTEINS; 1.
DR PANTHER; PTHR14791:SF22; PROTEIN KIBRA; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 27..60
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 633..756
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 408..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 81..108
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 275..302
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 334..389
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 984..1011
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 822..842
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1094 AA; 123173 MW; 4C2EF50BE1E7795A CRC64;
MCHWRGPGLI IAGRYTKPLT FADCISDELP LGWEEAYDPQ VGVYYIDHNT KTTQIEDPRV
QWRRGQEHML KDYLVLAQEA IAAQKEIYQV KQQRLELAQQ EYRQLHDVWE HKLGSQTSLL
SGSSSSSKYD PEILKAEIAT TKSRVNKLKR EVAHMKQELQ YKEHGFQTLK KIDMKMSDTQ
GGYKLDEAQA ILSEMKALKK AITSGEKEKQ DLIQSLARLK DSFVNDRGSQ SDLWASSVSV
ESSSPLLPRQ YLDVSSQTDV SGNFLASSSN QLAEKVRLRL QYEEAKRRIA NLKIQLAKLD
SEAWPGVLDS ERDRLILINE KEELLKEMRF ISPRKWTRGE VERLETERRR LEEDLQAARD
TQSKALTERL KLNSKRNQLV RELEETTRLV AMLHTQLKSL STSMLSLSSS SSPGSLASSR
GSLATSSQDS STSASFTDLY YEHLEQLEQL DSEYQNKLDL LLEGATGFRP SGCITTIHEN
EVAKTQKADT TSRMQALRSL SGTPKSMTSL SPRSSLSSPS PPCSPLVIDP LLTGDAFSSH
MDFDDAEISA NLSELTLNTG SGNCRLEEPR AGDKHLGQGL NTAGGPALKV AGVSAAVSDE
SVAGDSGVYE ASVQRPCVSE VMVFDTDDTE AVGTARVQIA MRYDDKNKQF AILVIQLSNV
PALLLQQDQK VNIRVAVLPC SESTSCLFRT RPVEASDNLV YNEAFWVSIS YPALRQKTLR
VDVCTVDKSH LEECLGGAQI SLAEICRSGE KSTRWYNLLS YKYQQKQNRK SKQGNSHSEV
PCAEKTDSVS ALLEQTAVEL EAVEKKLEES RSTLTSGESW QDEEVPDLEE QDEISENEAE
EEEEFCAGKS LWETEESLNS QLHTEIAVKV DKETNTESLA QSTTVVRPKD KRAANPPQTQ
FVRGSTIIRS KTFSPGPQSQ YVCRLNRSDS DSSTLSKKPP FVRNAMERRS VRVKRPSIKS
FGTERLIRTS LDLELDLQAS KTWHDQLVQE ISVLKELKEQ LEQAQSQGEK ELPQWVKDDE
RFRLLLRLVE KRVQNPEHKC ELKADKMMRA AAKDVHRLRG QSRKEPLEVQ SFREKMAFFT
RPRINIPTLS ADDV
//
