ID U3K5D9_FICAL Unreviewed; 830 AA.
AC U3K5D9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Taste 1 receptor member 1 {ECO:0000313|Ensembl:ENSFALP00000010243.2};
GN Name=TAS1R1 {ECO:0000313|Ensembl:ENSFALP00000010243.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000010243.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000010243.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000010243.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; U3K5D9; -.
DR STRING; 59894.ENSFALP00000010243; -.
DR Ensembl; ENSFALT00000010283.2; ENSFALP00000010243.2; ENSFALG00000009822.2.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00940000161264; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR Proteomes; UP000016665; Chromosome 21.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; IEA:Ensembl.
DR GO; GO:0050917; P:sensory perception of umami taste; IEA:Ensembl.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF3; TASTE RECEPTOR TYPE 1 MEMBER 1; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 532..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 724..745
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 751..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 530..793
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 803..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 88983 MW; 128D23BEE47AD4E1 CRC64;
MSECPCCPCP QRAVLSNNHS RFHSAAFKSH GYCLSQAMRF AVEEINNSST LLPNVTLGYE
IYDTCSEPTN FHATLCALAR KGRRDVQVLP SFQHYEPQAV AVIGPDSSRL ALTTAAVLSL
FLVPQISYEA STESLSLKRL YPSFLRTIPS DRQQVKAIFL LLQHFGWTWV VLLGSDNTYG
RASLDALQEL LTASNVCVAY RGTIPVNSDA SNPELHNLVQ ILTDVKVNVT VVFSTRSSVL
PFFEVVVQRN ITGMVWVASE DWSVAQSIWQ VPGIQNIGSV FGMAVEKPES MMLERFEAWK
MAEEGAEAEC ASSAEAGRES GGNTQLDCIQ CCTGCHALAT VPDMYDAQGS FNVYSAVYAV
AYGLHDLLGC ASGTCSKGII YPWQLLQKIR QVNFTLYKSR ISFDANGDIH KGYDIIMWKW
RGPNWASDVI GTFRVNPDRL SIDPDKVLWH TEDGQAPSSV CSELCEPGEM RLQQSRHKCC
FSCVACPPGT FLNTSDPFDC QACGLDEWAP AGSEVCFNRT VEFLSWSEPL SWALLALAVL
LMLLIVALAV LFALNASTPV VKSAGGKTCF LMLGSLACTC SSLFCYFGEP SRVACLLRVP
LFAISFTVFL SCVATRSFQI LCIFKLNTRC PALYEAWMRR QGPVLFVAAS TAAQAVLCVV
AEAASPSVPR REYSARDDGV VLECGHNAAA DAAIVYTVLL SAGCFVLSYA GTDLPAAYNE
AKSLTVSLLL HLGCSAAVLC SQGALRGRAE AAARVLSTLG TLAALLGGYF VPRAFVILLR
PHQNTAEHFQ MAIQEYTRRR AAGGGGGGGG GGGGGGGGGG GGGGGGGGGG
//
