ID U3KN20_RABIT Unreviewed; 578 AA.
AC U3KN20;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=SUFU negative regulator of hedgehog signaling {ECO:0000313|Ensembl:ENSOCUP00000026629.1};
GN Name=SUFU {ECO:0000313|Ensembl:ENSOCUP00000026629.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000026629.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000026629.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000026629.1,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000026629.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000026629.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02060858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017204012.1; XM_017348523.1.
DR AlphaFoldDB; U3KN20; -.
DR SMR; U3KN20; -.
DR STRING; 9986.ENSOCUP00000026629; -.
DR PaxDb; 9986-ENSOCUP00000026629; -.
DR Ensembl; ENSOCUT00000033584.2; ENSOCUP00000026629.1; ENSOCUG00000005781.4.
DR GeneID; 100345361; -.
DR CTD; 51684; -.
DR eggNOG; ENOG502QT57; Eukaryota.
DR GeneTree; ENSGT00390000009747; -.
DR HOGENOM; CLU_033906_0_0_1; -.
DR InParanoid; U3KN20; -.
DR OMA; CQIVGVT; -.
DR OrthoDB; 5385318at2759; -.
DR Proteomes; UP000001811; Chromosome 18.
DR Bgee; ENSOCUG00000005781; Expressed in testis and 15 other cell types or tissues.
DR ExpressionAtlas; U3KN20; baseline.
DR GO; GO:0005929; C:cilium; IEA:Ensembl.
DR GO; GO:1990788; C:GLI-SUFU complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0035904; P:aorta development; IEA:Ensembl.
DR GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR GO; GO:0021776; P:smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; IEA:Ensembl.
DR GO; GO:0021775; P:smoothened signaling pathway involved in ventral spinal cord interneuron specification; IEA:Ensembl.
DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
DR Gene3D; 3.30.1360.230; Sufu, C-terminal domain; 1.
DR InterPro; IPR020941; SUFU-like_domain.
DR InterPro; IPR024314; SUFU_C.
DR InterPro; IPR038489; SUFU_C_sf.
DR InterPro; IPR037181; SUFU_N.
DR InterPro; IPR007768; Suppressor_of_fused.
DR InterPro; IPR016591; Suppressor_of_fused_euk.
DR PANTHER; PTHR10928; SUPPRESSOR OF FUSED; 1.
DR PANTHER; PTHR10928:SF2; SUPPRESSOR OF FUSED HOMOLOG; 1.
DR Pfam; PF05076; SUFU; 1.
DR Pfam; PF12470; SUFU_C; 1.
DR PIRSF; PIRSF011844; Suppressor_of_fused_protein; 1.
DR SUPFAM; SSF103359; Suppressor of Fused, N-terminal domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 147..323
FT /note="Suppressor of fused-like"
FT /evidence="ECO:0000259|Pfam:PF05076"
FT DOMAIN 336..567
FT /note="Suppressor of fused C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12470"
FT REGION 1..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..109
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 578 AA; 63308 MW; 3F80BF6125512ED3 CRC64;
MGAGTGRAGA PPPWSPRGPE AHSGRLRGGD GWGGRCTVRR RGAGPRCSPH CLGESHPPSP
PAGPSVLFPS SALPGSPSAL RAGMAELRPS GAPGPSAPPA PGPTAPPAFA SLFPPGLHAI
YGECRRLYPD QPNPLQVTAI VKYWLGGPDP LDYVSMYRNV GSPSANIPEH WHYVSFGLSD
LYGDNRVHEF TGTDGPSGFG FELTFRLKRE TGESAPPTWP AELMQGLARY VFQSENTFCS
GDHVSWHSPL DNSESRIQHM LLTEDPQMQP VQTPFGVVTF LQIVGVCTEE LHSAQQWNGQ
GILELLRTVP VAGRPWLITD MRRGETIFEI DLHLQERVDK GIETDGSNLS GVSAKCAWDD
LSRPPEDDED SRSICIGTQP RRLSGKDTEQ IRETLRRGLE INSKPVLPPI NPQRQNGLTH
DRAPCLPLSL MSCSGSRKDS LESDSSTAII PHELIRTRQL ESVHLKFNQE SGALIPLCLR
GRLLHGRHFT YKSITGDMAI TFVSTGVEGA FATEEHPYAA HGPWLQILLT EEFVEKMLED
LEDLTSPEEC KLPKEYSWPE KKLKVSILPD VVFDSPLH
//
