ID U3KUE1_HBV Unreviewed; 400 AA.
AC U3KUE1;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Polymerase {ECO:0000313|EMBL:AFJ19372.1};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:AFJ19372.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AFJ19372.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AFJ19372.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HCC 5-8 {ECO:0000313|EMBL:AFJ19372.1};
RA Lee S.-A., Kim D.-W., Kim B.-J.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFJ19372.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HCC 5-8 {ECO:0000313|EMBL:AFJ19372.1};
RX PubMed=24025913; DOI=10.1128/JCM.01505-13;
RA Lee S.A., Kim K.J., Kim D.W., Kim B.J.;
RT "Male-specific W4P/R mutation in the pre-S1 region of hepatitis B virus,
RT increasing the risk of progression of liver diseases in chronic patients.";
RL J. Clin. Microbiol. 51:3928-3936(2013).
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DR EMBL; JQ611680; AFJ19372.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 176..400
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFJ19372.1"
FT NON_TER 400
FT /evidence="ECO:0000313|EMBL:AFJ19372.1"
SQ SEQUENCE 400 AA; 44067 MW; 4DDC0D4E9B585FFE CRC64;
GRSVFQTSTR HGDESFCSQS SGILSRSPVG PCVRSQLKQS RLGLQPQQGS LARGKSGRSG
SIRARVRPTT RRFFGVEPSG SGHIDNSASS ASSCLHQSAV RKTAYSHLST SKRQSSSGHA
VELHHIPPSS ARSQSEGPIF PCWWLQFRNS NPCSDYCLTH IVNLLEDWGP CTEHGEHNIR
IPRTPARVTG GVFLVDKNPH NTTESRLVVD FSQFSRGSTH VSWPKFAVPN LQSLTNLLSS
NLSWLSLDVS AAFYHIPLHP AAMPHLLVGS SGLPRYVARL SSTSRNINYQ HGTMQDLHDS
CSRNLYVSLL LLYKTFGRKL HLYSHPIILG FRKIPMGVGL SPFLLAQFTS AICSVVRRAF
PHCLAFSYMD DVVLGAKSVQ HLESLFTSIT NFLLSLGIHL
//
