ID U3KYI3_9BACT Unreviewed; 144 AA.
AC U3KYI3;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Mercuric resistance operon regulatory protein {ECO:0000256|ARBA:ARBA00017146};
OS uncultured bacterium.
OG Plasmid pWEC911 {ECO:0000313|EMBL:AFR44306.1}.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:AFR44306.1};
RN [1] {ECO:0000313|EMBL:AFR44306.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pWEC911 {ECO:0000313|EMBL:AFR44306.1};
RX PubMed=22936717; DOI=10.1093/molbev/mss210;
RA Sen D., Brown C.J., Top E.M., Sullivan J.;
RT "Inferring the Evolutionary History of IncP-1 Plasmids Despite Incongruence
RT among Backbone Gene Trees.";
RL Mol. Biol. Evol. 30:154-166(2013).
CC -!- FUNCTION: Mediates the mercuric-dependent induction of mercury
CC resistance operon. In the absence of mercury MerR represses
CC transcription by binding tightly to the mer operator region; when
CC mercury is present the dimeric complex binds a single ion and becomes a
CC potent transcriptional activator, while remaining bound to the mer
CC site. {ECO:0000256|ARBA:ARBA00024874}.
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DR EMBL; JX469833; AFR44306.1; -; Genomic_DNA.
DR AlphaFoldDB; U3KYI3; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045340; F:mercury ion binding; IEA:InterPro.
DR GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-KW.
DR CDD; cd04783; HTH_MerR1; 1.
DR Gene3D; 1.10.1660.10; -; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR011794; MerR.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR047057; MerR_fam.
DR InterPro; IPR015358; Tscrpt_reg_MerR_DNA-bd.
DR NCBIfam; TIGR02051; MerR; 1.
DR PANTHER; PTHR30204:SF67; HTH-TYPE TRANSCRIPTIONAL REGULATOR MLRA-RELATED; 1.
DR PANTHER; PTHR30204; REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR; 1.
DR Pfam; PF00376; MerR; 1.
DR Pfam; PF09278; MerR-DNA-bind; 1.
DR PRINTS; PR00040; HTHMERR.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR PROSITE; PS00552; HTH_MERR_1; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Mercuric resistance {ECO:0000256|ARBA:ARBA00022466};
KW Mercury {ECO:0000256|ARBA:ARBA00022914};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Plasmid {ECO:0000313|EMBL:AFR44306.1};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 7..76
FT /note="HTH merR-type"
FT /evidence="ECO:0000259|PROSITE:PS50937"
SQ SEQUENCE 144 AA; 15695 MW; AF8EFCB9B5F0DC44 CRC64;
MENNLENLTI GVFAKAAGVN VETIRFYQRK GLLPEPDKPY GSIRRYGEAD VVRVKFVKSA
QRLGFSLDEI AELLRLDDGT HCEEASSLAE HKLKDVREKM ADLARMETVL SELVCACHSR
QGNVSCPLIA SLQGGTSLAG ASTA
//
