ID U3Q5C6_9FLAO Unreviewed; 590 AA.
AC U3Q5C6;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Arginine--tRNA ligase {ECO:0000256|HAMAP-Rule:MF_00123};
DE EC=6.1.1.19 {ECO:0000256|HAMAP-Rule:MF_00123};
DE AltName: Full=Arginyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00123};
DE Short=ArgRS {ECO:0000256|HAMAP-Rule:MF_00123};
GN Name=argS {ECO:0000256|HAMAP-Rule:MF_00123};
GN ORFNames=K645_2141 {ECO:0000313|EMBL:AGW86207.1};
OS Blattabacterium sp. (Nauphoeta cinerea).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Blattabacteriaceae; Blattabacterium.
OX NCBI_TaxID=1316444 {ECO:0000313|EMBL:AGW86207.1, ECO:0000313|Proteomes:UP000016822};
RN [1] {ECO:0000313|EMBL:AGW86207.1, ECO:0000313|Proteomes:UP000016822}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nauphoeta cinerea {ECO:0000313|Proteomes:UP000016822};
RX PubMed=24071059; DOI=10.1016/j.ygeno.2013.09.003;
RA Kambhampati S., Alleman A., Park Y.;
RT "Complete genome sequence of the endosymbiont Blattabacterium from the
RT cockroach Nauphoeta cinerea (Blattodea: Blaberidae).";
RL Genomics 102:479-483(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC EC=6.1.1.19; Evidence={ECO:0000256|ARBA:ARBA00001766,
CC ECO:0000256|HAMAP-Rule:MF_00123};
CC -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00123}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00123}.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|HAMAP-Rule:MF_00123,
CC ECO:0000256|RuleBase:RU363038}.
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DR EMBL; CP005488; AGW86207.1; -; Genomic_DNA.
DR AlphaFoldDB; U3Q5C6; -.
DR STRING; 1316444.K645_2141; -.
DR KEGG; blu:K645_2141; -.
DR PATRIC; fig|1316444.3.peg.436; -.
DR eggNOG; COG0018; Bacteria.
DR HOGENOM; CLU_006406_6_1_10; -.
DR Proteomes; UP000016822; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1360.70; Arginyl tRNA synthetase N-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR HAMAP; MF_00123; Arg_tRNA_synth; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR001278; Arg-tRNA-ligase.
DR InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR InterPro; IPR035684; ArgRS_core.
DR InterPro; IPR008909; DALR_anticod-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00456; argS; 1.
DR PANTHER; PTHR11956:SF5; ARGININE--TRNA LIGASE, CYTOPLASMIC-RELATED; 1.
DR PANTHER; PTHR11956; ARGINYL-TRNA SYNTHETASE; 1.
DR Pfam; PF05746; DALR_1; 1.
DR Pfam; PF00750; tRNA-synt_1d; 1.
DR PRINTS; PR01038; TRNASYNTHARG.
DR SMART; SM00836; DALR_1; 1.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF55190; Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|HAMAP-Rule:MF_00123};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00123};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00123};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|HAMAP-Rule:MF_00123};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00123};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00123}.
FT DOMAIN 472..590
FT /note="DALR anticodon binding"
FT /evidence="ECO:0000259|SMART:SM00836"
FT MOTIF 125..135
FT /note="'HIGH' region"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00123"
SQ SEQUENCE 590 AA; 69475 MW; 984CC10AEF69D073 CRC64;
MLSMNDHLQS IEKIVIESIF VLYKIKSCPE LDFQYTKKEY PGDITLVLFS LSKKLKKPVE
KIGKDIGNYV QNKLKGLIQF SIIRGFLNFI FEDDYYIYLL KKMLNTNFYD LKYPTKKIMV
EYSSPNTNKP LHLGHIRNSL IGASLAEILK MVGHEIIRTQ IINDRGIHIC KSMIAWKRFG
KGKTPDSAKM KGDHFVGKYY SLFDKISCKE IQELDNKSSK EDYNQYSILN QARELLKKWE
LGDSEIRNTW RTMNQWVYNG FEETYKKLGI HFDKIEYESD IYKMGKEIVK KGLKKGIFFQ
KKDGSIWIDL TKEGFDQKLL LRSDQTSVYI TQDIGTAVER FKKYNIDQII YIVGKEQDYH
FQVLFNILKR LGYIWVNKLF HLSYEMVYLP SGRMKSREGN IVDADSIILE MYSIAKKNFS
NKFIKKEEQK QSSEILGLGA LKYFFLKIDP RKKIIFHPEK SIDFKGKTGT YIQYTYSRIR
SLERKFLNLC PLLNYHWSNI KFDIHEKNMI KILQKYPLVL KKSAIQLNPS LIANYIYEVS
KIFNHLYQYK RLIDPLNVIH SNICMNIIHV TGNVLKSGMN LLGIKMLDRI
//
