ID U4KVH2_PYROM Unreviewed; 2199 AA.
AC U4KVH2;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Similar to Pre-mRNA-splicing factor brr2 acc. no. Q9UT24 {ECO:0000313|EMBL:CCX04901.1};
GN ORFNames=PCON_03898 {ECO:0000313|EMBL:CCX04901.1};
OS Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Pyronemataceae; Pyronema.
OX NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX04901.1};
RN [1] {ECO:0000313|EMBL:CCX04901.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS100304 {ECO:0000313|EMBL:CCX04901.1};
RC TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX04901.1};
RX PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT "The genome and development-dependent transcriptomes of Pyronema confluens:
RT a window into fungal evolution.";
RL PLoS Genet. 9:E1003820-E1003820(2013).
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DR EMBL; HF935219; CCX04901.1; -; Genomic_DNA.
DR STRING; 1076935.U4KVH2; -.
DR eggNOG; KOG0951; Eukaryota.
DR OMA; QTEIQYY; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000018144; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 531..715
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 742..960
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1385..1561
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 226..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..272
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2199 AA; 248122 MW; 1087F220780B65A0 CRC64;
MADQSQYKYA AMSNLVLQPD KRFFSRRTDE PTGDPETLAG KVDIKEMGSR VMRDSAPKEK
LKKKKGTEKI NLEAMDEGRE ILERERKKRK RGGNSAFGES ILSATDDVLD LIYHPRTAAT
RETYSLILTL TAGILGDVPH SVVRSAADAV LEILKDPDGS KKDLDKKRDI DDILGDKMES
KKFSELVSLS KKITDYNAGD EDEEMKEADG EAEEIDDREG VAVVFEDESD DDEDVGQYEV
RDESDDEAAA GDDDEATADK PTGEDEEGEE DGLVIGVDRR KKDKKESADK DIVAASDIDA
FWLQRQITNI YSDPHLASIK ATAALDILSV PESELQVEND LMELFDFEHF ELVKVLKKNQ
IKIVWCTKLA RAGEGSEEYL AIEKEIKQQG HGSILEELAG RSVESSERKA TKSKGDVMEI
DVPASALPTG PEKQVAANGL TGGLQPRKII DLDNLTFEQG NHLMTNTNVK LPQGSTKRTY
KGYEEIHVPA PKRRSDANEP KLIPVSTMPE WAQAPFKSNP TLNRIQTQCF PTAFEDDGNM
LVCAPTGSGK TNVSMLTILR EIGKHRDPVS GVIKTDDFKI VYIAPLKALV QEQVGNFGKR
LEPYGIKVAE LTGDRQLTKQ QIAETQIIVT TPEKWDVITR KATDLSYTNL VRLIIIDEIH
LLHDERGPVL ESIVSRTIRK QEITLEPVRL VGLSATLPNY RDVATFLQVD PTKGLFHFDA
TFRPCPLKQE FIGVTDKKAI KQLQTMNEVC YTKVIEQAAS NQMIIFVHSR KETAKTAKFI
RDKALEKETI QTILKSDAGT RELLQHEADQ ASDVNLKDLL PYGFAIHHAG MTRADRTTVE
DLFNDKFIQV LVCTATLAWG VNLPAHTVII KGTQIYSPEK GAWVELSPQD MLQMIGRAGR
PQFDTYGEGI IITTQSEIQY WLSLLNQQLP IESQFMRKMA DNLNAEIVLG TVRTRDEAVE
WLGYTYLYVR MLRSPGLYGV GADYSDDVSL EQKRVDLIHS AATILEKCNL IKYDKKTGKL
QSTELGRIAS HYYISHNSMM TYNTHLQPQI STVELFRVFA LSEEFKYIPV RSEEKLELQK
LLQRVPIPVK EGIEEPQAKI NVLLQAHISR LGLEGLAMMA DMVYVTQSAG RILRAIFEIC
LKRGWSSVAK LALDLCKMAE KRMWRTMSPL RQFPLPANQL SPIVTKAERA AEFTWSKYFT
MDVPHFTELF GGSSRTGKLV HSLVERFPRL NVQAQFQPIT RSMLRVELTI TPEFIWDDAY
HGAAEQFWIM VEDCDGEQIL YHDLFVLRKT YAESQNNEHL VEFTVPITEP MPPNYFITVI
SDRWMHSETK LAVSFRKLIL PEKFPPHTQL LDLVPLPVEA LKKKDYVKLY PEWRHFNKIQ
TQVFKSLFDT EDNVFIGAPS GSGKTICAEF ALLRHWMQPE AGRAVYIAPF QELVDQRHED
WKKRMSKIAG GKEIVKLTGE TSADLKLLER GDLILATPSQ WDLISRQWQR RKNVQTVELF
IADDVHMLGG VNGFIYEIIV SRMQYMAVQT ENALRIVALS VSLSNPRDLG EWIGADKHTI
YNFSPGSRPV PLEIHIQSFT IPHFPSLMMA MAKPTYNAIC SVPAEKPVIV FVPSRKQCRS
TAVDLLSYCV ADDQEDKFRN VALEDISDYL NRIDEGALAE SLSHGIGYYH EALSKKDKGI
VEGLFATGAI KVLLASRDVA WELNTPAHLV IVMGTSFFEG REHRYIDYPL SEILKMFGKA
SRPGEDKFGK AILMTTATKK DYYLKFLNEA LPIESHLPAY LHDAFVTEIS TTTIASTQDA
VDWSTYTYFY RRLLANPSFY SLTDTSHDGL SAHLSELVEN TLKDLAEAKI IDMDEEDDTV
TALHPAMIAA YYNISFITMQ TFLLSLTGRT KLKGLLEIVT SATEFEAVQV RRHEDRILRR
IYDNIPVKMS EPNYESPHFK AFALVQAHFS RMQLPADLAK DQEIVVSKIL NLLSGCVDVL
SSEGHLNAIN AMEMSQMVVQ AMWNRDSPLK QIPYFGPELV TKANEAGVND ILEFMDAMAD
DGSRDGLLKA LGLGQRQLAD IANFTNNKYP NIDMEHELED EAVTAGSPAY IRVKIERDVD
EDQEVDTTVH APFYPGTKME NWWLVVGEEE SKSLLAIKKV TIQRRLEVRL EYTVPTAGHK
KLTLSLMSDS YVGVDQEQQF EVDVAEGEDE DEDEEMEDA
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