ID U4LNP8_PYROM Unreviewed; 915 AA.
AC U4LNP8;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Similar to DNA mismatch repair protein msh-2 acc. no. O13396 {ECO:0000313|EMBL:CCX33776.1};
GN ORFNames=PCON_01852 {ECO:0000313|EMBL:CCX33776.1};
OS Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Pyronemataceae; Pyronema.
OX NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX33776.1};
RN [1] {ECO:0000313|EMBL:CCX33776.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS100304 {ECO:0000313|EMBL:CCX33776.1};
RC TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX33776.1};
RX PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT "The genome and development-dependent transcriptomes of Pyronema confluens:
RT a window into fungal evolution.";
RL PLoS Genet. 9:E1003820-E1003820(2013).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; HF936189; CCX33776.1; -; Genomic_DNA.
DR AlphaFoldDB; U4LNP8; -.
DR STRING; 1076935.U4LNP8; -.
DR eggNOG; KOG0219; Eukaryota.
DR OMA; LVRFPQK; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000018144; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 726..742
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 416..492
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 915 AA; 103029 MW; 78C06D0FC4640352 CRC64;
MGSRPELKVE DESGFISFFN RLPETDAIRL FERNDFYTVH GRDAIFVATT VYKTTSVIRQ
LGSSRNALES CTLSIAAFRN FLREVLFVQG KRVEIWQQKG KGSWEIGKQA SPGNLQDVEE
DFAGQIESAP VILAVKIQAK GDERLVGVCF ADASVRELGM SEFQDNEVYS NFESLIIQLG
VKEVVLQADT NGKDLELKKV RELIDRCSIV LTHNKSADFA VKDIEQDLSR LLTSDGATGI
LPHAENKVAM GAANALIKYL SLMSDESNFG KYHLYQHDLS QYMKLDASAV RALNLMPGPR
DGSKNMSLYG LLNKCKTSIG TRLLGQWLKQ PLMTLEDIER RHILVEAFVE DTDLRQTMQE
EHLKKIPDLY RLSKRFQRGL ANLEDVVRAY QVVITLPGFI GTLEGVMDEK YRDPLDEQYT
NKFREVSANL EKLQELVETT VDLDAIDNHE FVIRPEFNED LMNIRARIDD LKDQMNQEHK
RASRDLDQER DKKLFLENHK VHGWCFRLTR TEAGSIRNKK EYKEITTQKN GVYFTTNTLK
DLNRDTDQAT QNYDRTQRGL VDEVVNVASS YCPVLEELAG VLAHLDVIVS FAHVSVHAPT
AYVRPKMHAR GTGNTILKEA RHPCMEMQDD IQFITNDVSL VRGESEFLII TGPNMGGKST
YIRQIGVIAL MAQAGCFVPC SEAELTIFDC ILARVGASDS QLKGVSTFMA EMLETATILK
SATSESLIII DELGRGTSTY DGFGLAWAIS EHIVKEIRCF SMFATHFHEL TALSDEYPAV
KNLHVVAHIG DRKEEGREVT LLYKVDEGVC DQSFGIHVAE LVKFPAKVVK MAKRKADELE
DFTSKHNDDN VHCSKEQIAQ GSALLKKMLL EWKQNVASGD MSPAEKAAEL KKLAQGPYKD
AFENDPFFKS IKTLA
//
