ID U4LXW2_PYROM Unreviewed; 544 AA.
AC U4LXW2;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN ORFNames=PCON_04126 {ECO:0000313|EMBL:CCX34643.1};
OS Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Pyronemataceae; Pyronema.
OX NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX34643.1};
RN [1] {ECO:0000313|EMBL:CCX34643.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS100304 {ECO:0000313|EMBL:CCX34643.1};
RC TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX34643.1};
RX PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT "The genome and development-dependent transcriptomes of Pyronema confluens:
RT a window into fungal evolution.";
RL PLoS Genet. 9:E1003820-E1003820(2013).
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
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DR EMBL; HF936586; CCX34643.1; -; Genomic_DNA.
DR AlphaFoldDB; U4LXW2; -.
DR STRING; 1076935.U4LXW2; -.
DR eggNOG; KOG1369; Eukaryota.
DR OMA; YPNFEGY; -.
DR OrthoDB; 5481886at2759; -.
DR UniPathway; UPA00109; UER00180.
DR Proteomes; UP000018144; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.40.367.20; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR019807; Hexokinase_BS.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443:SF30; GLUCOKINASE-1-RELATED; 1.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR Pfam; PF00349; Hexokinase_1; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00378; HEXOKINASE_1; 1.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU362007};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362007};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT DOMAIN 14..216
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 226..531
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 544 AA; 58400 MW; 6B7A15EE6B8B3689 CRC64;
MAPTTDYAPM IAKAEAIAKE FDFSAEDVRK GVKEFLRLMV LTAPDVGLQN DGKAMTMIPT
YVTGVPNGTE KGVYLAVDLG GTNFRVCSVS LSGDTKFTLT QSKVAIPRDM MVSDSHTLFS
FLAKEVEKFV KTHHADHFEE DISHKLQLGF TFSFPVDQRA VNKGYLIRWT KGFDIKDAVG
KDVCELLQKE IDALGLPVKV AALVNDTVGT LMARSYTSPG STGTLLGAIF GTGTNGAYVE
KLSKITKMTK PDAQVGEYDK STGEMVVNTE WGSFDNALKV LPDTIYDQQL DANSVNPGIQ
MFEKRISGMF LGEILRNAIL GLKKDAGLLN ASTIAEDAPL YTPWSVDTSV LSFIEADNTS
DLSESKKVLE EQLGIPAANL HTEEARAVKI LVHAIGKRSA RLSAVPIAAI VIATGKVDNL
RPKPVKRMSI VEQGLEAIKS ALTGKLPAGA ADIPTAPTVK GDKEKAQTEE DLEVIDIGVD
GSVVEHYPGF EKFVREALRE VHELGVEGEE RIRMGVAKDG SGVGAALIAL VAAKAAGVQI
PSSD
//
