ID U4MHY5_CAPCA Unreviewed; 450 AA.
AC U4MHY5;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Wt1 protein {ECO:0000313|EMBL:CDG23662.1};
GN Name=WT1 {ECO:0000313|EMBL:CDG23662.1};
OS Capreolus capreolus (European roe deer) (Cervus capreolus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Cervidae;
OC Odocoileinae; Capreolus.
OX NCBI_TaxID=9858 {ECO:0000313|EMBL:CDG23662.1};
RN [1] {ECO:0000313|EMBL:CDG23662.1}
RP NUCLEOTIDE SEQUENCE.
RA Kropatsch R., Dekomien G., Akkad D.A., Gerding W.M., Petrasch-Parwez E.,
RA Young N.D., Altmueller J., Nuernberg P., Gasser R.B., Epplen J.T.;
RT "SOX9 duplication linked to intersex in deer.";
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00005682}.
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DR EMBL; HG326978; CDG23662.1; -; Genomic_DNA.
DR AlphaFoldDB; U4MHY5; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR InterPro; IPR000976; Wilms_tumour_N.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23235:SF71; KRUEPPEL-LIKE FACTOR 16; 1.
DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF02165; WT1; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR PRINTS; PR00049; WILMSTUMOUR.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 324..353
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 354..383
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 384..411
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 415..444
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 48..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..73
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 450 AA; 49241 MW; 333E184FBAA62C72 CRC64;
MGSDVRDLNA LLPAVPSLGG GGGCALPVSG AAQWAPVLDF APPGASAYGS LGGPAPPPAP
PPPPPPPPPH SFIKQEPSWG GAEPHEEQCL SAFTVHFSGQ FTGTAGACRY GPFGPPPPSQ
ASSGQARMFP NAPYLPSCLE SQPAIRNQGY STVTFDGTPS YGHTPSHHAA QFPNHSFKHE
DPMGQQGSLG EQQYSVPPPV YGCHTPTDSC TGSQALLLRT PYSSDNLYQM TSQLECMTWN
QMNLGATLKG VAAGSSSSVK WTEGQSNHGT GYESDNHTTP ILCGAQYRIH THGVFRGIQD
VRRVPGVAPT LVRSASETSE KRPFMCAYPG CNKRYFKLSH LQMHSRKHTG EKPYQCDFKD
CERRFSRSDQ LKRHQRRHTG VKPFQCKTCQ RKFSRSDHLK THTRTHTGKT SEKPFSCRWP
SCQKKFARSD ELVRHHNMHQ RNMSKLQLAL
//
