ID U4QPX6_9BACT Unreviewed; 311 AA.
AC U4QPX6;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:EIJ75574.1};
GN ORFNames=C75L2_00410005 {ECO:0000313|EMBL:EIJ75574.1};
OS Leptospirillum sp. Group II 'C75'.
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Leptospirillum.
OX NCBI_TaxID=1159328 {ECO:0000313|EMBL:EIJ75574.1, ECO:0000313|Proteomes:UP000016760};
RN [1] {ECO:0000313|EMBL:EIJ75574.1, ECO:0000313|Proteomes:UP000016760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22539719; DOI=10.1126/science.1218389;
RA Denef V.J., Banfield J.F.;
RT "In situ evolutionary rate measurements show ecological success of recently
RT emerged bacterial hybrids.";
RL Science 336:462-466(2012).
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DR EMBL; JH660605; EIJ75574.1; -; Genomic_DNA.
DR AlphaFoldDB; U4QPX6; -.
DR HOGENOM; CLU_035117_0_6_0; -.
DR Proteomes; UP000016760; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 10..171
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 174..290
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 180
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 311 AA; 33019 MW; B9000D9A5BDB6C26 CRC64;
MEKFEIQPWK MGVVGVGRMG SNMALRLNDV GYRVASVYDV RLEAARRVAD ETGASVARTL
AEVTAQSDVI ITVVGTDREM DALFAETGDS LLVGASGRVF VNCATLSPDI HVEVERRSND
RGADCLEASM ASSITQAREG TLYLMVGGKK EAFERVRPVL EAMSASLRWI GPAGQAAKIK
ALVNMVMNIN TAGLAEGLGL ADALGLDLAM VREVFSQTGA ASRVLETDGA DMQNREHDVY
FSAAHAAKDS RIALALAARV GLNLPLAKAA SGQYDRMVSL GLGEIDKSGV SELTFRARRG
SQQTPEPGGE A
//
