ID   U4U137_DENPD            Unreviewed;       483 AA.
AC   U4U137;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=D910_01658 {ECO:0000313|EMBL:ERL96254.1}, D910_03417
GN   {ECO:0000313|EMBL:ERL86003.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL86003.1, ECO:0000313|Proteomes:UP000030742};
RN   [1] {ECO:0000313|EMBL:ERL86003.1, ECO:0000313|Proteomes:UP000030742}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA   Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA   Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT   a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
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DR   EMBL; KB631768; ERL86003.1; -; Genomic_DNA.
DR   EMBL; KI210422; ERL96254.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4U137; -.
DR   STRING; 77166.U4U137; -.
DR   OrthoDB; 1366859at2759; -.
DR   Proteomes; UP000030742; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd16018; Enpp; 1.
DR   Gene3D; 3.30.1360.180; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR002591; Phosphodiest/P_Trfase.
DR   PANTHER; PTHR10151:SF120; BIS(5'-ADENOSYL)-TRIPHOSPHATASE; 1.
DR   PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR   Pfam; PF01663; Phosphodiest; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..483
FT                   /note="Ectonucleotide pyrophosphatase/phosphodiesterase
FT                   family member 5"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007730793"
FT   TRANSMEM        422..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   483 AA;  54865 MW;  AECB83D25D2C3E34 CRC64;
     MWPSAALLCC VCISCAHALS NHPILVVVSY DAFRYDFFEQ RLPHMEQVRA QGVYAEYLIN
     VFPTKTFPNH HSISTGLYTE VHGVIGNSFY DSALKNVVGM GFEMYHYNDD VKPIWRLNED
     LGEGRHSGAV MWPGSNFPYQ NKTITWTLPF EAGYDWQKRV DHAISWILDP FRPANLVMLY
     FEEPDTHGHA FGPNSEVVRT QVHKLDNITG YLHEQLHAHG LSDLVNVIHV SDHGMTAVTP
     PRFINITQYM QNGTYEWAGA SPAIQITPHQ GHEQEIYSGL KAASRRNGHF GVYNKSEYLE
     RWHYKNNSRS PPILVLADVG YALDDLIRAA PRFAEKYNFT LTNSSEFGVH GYDYTETQMH
     PFFMAVGPQI RQHTKVEPFH TVDLFYLFCA ILDLPAPANN GSIIPTQLVL QPMPGRFRVG
     TIVMISVGGV LLVLILVILT VVFTLMLIKR QQNITTTAAL NKRFPQTFQN YIEAQHLLEP
     EDA
//