ID U4U3A6_DENPD Unreviewed; 4081 AA.
AC U4U3A6;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=D910_04933 {ECO:0000313|EMBL:ERL87542.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL87542.1, ECO:0000313|Proteomes:UP000030742};
RN [1] {ECO:0000313|EMBL:ERL87542.1, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB631968; ERL87542.1; -; Genomic_DNA.
DR STRING; 77166.U4U3A6; -.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT DOMAIN 1407..1546
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1688..1844
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2032..2180
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 671..698
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2852..2900
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4081 AA; 465918 MW; 248E93C140C802C4 CRC64;
MFVVVKRGDG ESASGSHGFR GSSLPSLKGR TRLGARLMCA PPMPTHGPRR SNAVPFHIPH
KRLLEKIEFK QEEPEPLTGF KKYQEDILTK RRRLPPIKAK VVGESGPGSS GQPSIQTAVT
FFDKVEEEQR QVAHKAVNSS RVKDTSQKLT KVADQKEWID KMRRSKDGSF VYFTYAVPKS
SERFNPYMLK VVGYKEVDKN NFFTMSAKGV MQHIGSEVVF TPLDKWEAEY DMFQRLMKIR
TFRTFRKWKG FYVWRKNIIY CKFTSAQKHL SQNMFLLNPL LRQGLIDIQY MCHKMVDTSF
VELSQTENVW LFYFIENQMD KLNKIRMEIA EFHELAKEIV ANACHGALLA KGFVADERIV
DEQKDQRRRR QQKASYIEQA SKKKFCERLA AYIMLVDYMS INMLHQLIIN SINALNELFE
KHSKYLPPDE QLERTEVDTL LETGRESEDP SLPLFVVNVM LEPEEVKLDP PLGVAKCIFQ
QTIELWEQSC REVKSFVADP FYSLFTTPVI NEKIEDRICG WGPTLDFYLG KDEKLEEDTR
KVFGYFELNY NCASTYVKRL EYIREFFAED LRVQEEDVQR ETVTENFRNM CIRYHNEIVT
IEKITKTQPL GLLYLMLNDF RDTALPEPRR LLEIAKNVIP WIGHEKVSSL IQQVEETEIY
LGQEPVSTAD YVKYLEYIEE ATSRVDKMEE QLDYCKELYD ITEEFAIPVA QEEMTNYLGL
SVSLGNLRNF VDKKIEETGR IVKAFNDQMN KDISGLISEV GLIKDECTQP WLYDIASNID
EVSEFLADLY DRLLTCQTKA VEFKNYQKQF RLEVSRFDML EEVMNDVKLR MLLWESVDSW
AKTVDEWYHC DFGTLNVEDM NLFTAKNVKN INQLEKGLPP NLIVPKLKDE VELMKDKLPV
ITYLRNPALK ARHWIKVENV LNHKFKAEEE MTLEQLESLN VFSYPQELME ISGQASSEAG
LEALLRKAPW KGLEYIVISH KDAKDVFILG SLEDVQAVLD ESNINITTIA SSRHVGPIKS
RVEEWQKNLD LFTHTLDEWM MCQQSWVYLE VIFSAPDIQR QLPNEAKLFV IVDKSWKDIM
RRTAKMPIAM EATLQPGLLE TFQRNNALLE QIMKCLESYL ETKRVAFPRF YFLSNDELLD
ILAQTRNPHA VQPHLRKCFD AISKLEFGMK PAEEGEESKE GAKEGKKEKA PTMVLTTDII
AMISPEGERV QLSKGLKARG NVEDWLGKVE ESMFLSLKKC MKVSISHYMQ KPRTEWVVCH
ANQIILTVSQ IMWAKGVHEI LDGEGNVMKK MEQYEQKCIK DLNDLAVLVR SDLASVTRKI
LIALITIDVH ARDTIQNMVK SKVSNSNNFD WLKVLRYYWM ENIDDCLAKM SSASYLYGYE
YLGAGGVLVI TPLTDKCYLC LMGALQLDLG GAPAGPAGTG KTETTKDLAK ALAIQCVVFN
CSEGLDYKMM GRFFSGLAQS GAWCCFDEFN RIDIEVLSVI AQQLITIRNA KAAKLQRFMF
EGREIKLIQK CAAFITMNPG YAGRTELPDN LKALFRPISM MVPDYALIAE VILYSEGFES
SKNLSQKMVQ MYKLCSEQLS QQDHYDFGMR AVKSVLVMAG SLKRANPDRN EDVVLICALR
DSNLPKFLSD DAVLFQGILG DLFPGTELPV SDYGVFQETM VEIMKSNNLQ PELCMINKVI
QLYETMIVRW GVMLVGPTGG GKTTILNTLN GSLTKMCEDG QEGPFYHQVH TYIMNPKAVS
AGELYGEVNA FTLEWRDGLM GIMMRTAVQS TTEDHQWIIC DGPVDAVWIE NLNTVLDDNK
MLCLANSERI KLTPYVHMVF EVQDLAQASP ATVSRCGMVF VDSEELKWMP YVKSWINTIS
DSLLNEELKE FLTSLFATYV QDGFDFVKKN CIYAIHQVEV SKVKMICSLI QSHMALPGAM
EKIGERAKVR CFVCQVFISS YMWGLGGNIT EDSREKFEVF VQSQFEECSD ARLPPGQDMW
YVYMDVQTKR LTPWQNIMPQ FVYDKETPFF DTLVPTLDTV RFGYIMERLI HVGHPVMITG
DTGVGKSVVA KDVLNRLGAS EHFVPATMNF SAQTSSMRTQ EIIELKLERK KKTLLGAPLG
KKVIIFIDDV NMPKLETYGA QPPIELIRQL LDYGGLYDRE KLFWKDIRDV ILTTACAPPG
GGRNPLTPRF VRHFGMLLIP SPNELALKAI FKAILKGFLN DFSNECRDLG DYMVNAAVDI
YDRIARDLLP TPSKSHYIFN LRDLSKCVQG VTQADAGTMR GEMEIMRLFY HECLRVFHDR
LINVEDKSYF YYLMKEICSR NFGTPVLQLP DNTGLIENPP ILLFGDFMQF GAERENRIYE
ELKNIDKVKS LLQDYLDDFN LMYNKDMQVI FFMMAVEHCV RIARILRSER GNALLVGVGG
MGKQSLTKLA SHVNGYKCFQ IELVRNYDHS SFFEDLRKMY AHAGVGNMDT VFLFTDTQIV
QEEFLEDINN MLNSGDVPNL FEADEYEKVV IGCRDAAKKA GCPDGRDHIY EYFISRVRSN
LHLVICMSPV GDAFRRRCRM FPSLVNCCTI DWFEKWPQEA LLSVAQSSLK TLGSVELCDS
LAIVCVTIHE SVEIMTEKFY REMKRYYYTT PSSYLELIKL YKVMLRDRKD KITKTRDRIA
NGLQKLYQTN DVIDTMKETL IALEPELAKK SIAVAELMKN LAKEQKSADK VRVTVKGDEE
TAKAKADETQ VLADDAQRDL DTALPALDAA TKALEALNKN DINEVKVFQK PPKLVQFVME
SVCILLGAKT DWAAAKVVLG DTNFLKKLQD YDKDHITDLM LKKLKTYIEH PDFVPEKVVT
VSRACKSLCM WVRAVDMYAK VYKIVEPKRK KLQGAEKELN AVMSLLREKQ KQLADVEAMI
AGLEAKFNAT VAEKEALENN IALTSARLNR AGRLNIALGD EQTRWEESVK KFAIELTNCV
GDVLMAAACV AYQGAFTANY RQELTSMWET KCIEQSIPST ENFNLLNVLA DAYEIRMWNS
CGLPRDSVST ENAIMVTKAG RWPLMIDPQE QANRWIRQME GGNNLKIIKL TDSSFMRVLE
NGIRIGMPVL LEEVGETLDP TLAPILMKQT FVLGGRTLIH LGDSDVEYDQ NFKLYITTKL
ANPHYLPEIC IQVTIVNFTV TPSGLEDQLL ADVVRLERPE LEQQRNELVV RINADKTQLK
GIEDKILYLL YHSEGNILDD EELIETLNES KETSAIIEAR LVETEATEEK ISIAREKYRS
VATRGSVLYF VVAELAEIDP MYQYSLKYFS QVFDNVILTS TKDPVLEKRL NTLRVEITLA
VYTIISRGLF ERHKLVFSFM LCIAIMQQEG RISEVQWSFL LRGPVGSKSG TKKPDVATVT
DGMWQAANYL ASSYEQFRGL PEEITRAMTV TVGSYHLVIK VVSTALASKV DWDHTLTDFE
KLMLIKTMQE EKLVFAITEF VKLNLGQAFI ESPQVSLNLL YQDTSNAVPL IFVLSTGSDP
FGAFQRFAAE MGFTEKLKSI SLGQGQGPVA ERLIHGALET GDWIFLQNCH LATSWMLSME
RIVLEIAENA AKLNKAFRLF MSSMPSKCFP VAVLQNSVKV TNEPPKGLRA NMKRAFAEML
EGFFEEHPLQ QKWRTILFGI CMFHAVVQER KKFGPLGWNI VYEFNDSDRD FAFNTFQMFC
AEGVIPWDAL EYLTGEITYG GRVTDYWDLR CLKTILRIFF SAQTLTKNYK YSASGTYYCP
DYSHLAEYRE FIDKFPIIEE PEIFGMHENA NIAFQIKETQ TVIRTIMECQ PRSDGGGEGK
SSDEIVYELA DSVINAIIPQ IQSEEVNIYL FKKDDKGRVP SLTTVLTQEI DRYNKLLKLV
HSSMDQLKKA IKGLVVMSEA LEDVYKAFMN NQVPKMWSAK AYNSLKSLGS WVFDLTLRLD
FISVCIMIAG CTDEICLLLG FLTGTLQTHA RKYNLPIDKL KFDFVIKPVN LSQEEIKLEH
DAEGKEVYDL YRPLVAPEDG VLVHGLFVDA GRWDMKAMKL VDPKPGEINP PFPVIHMTPT
TNMPEDDPRY VCPLYKTSIR AGVLSTTGHS TNFVIAVLLP TAQAQSYWIL KGTALLTQIT
D
//
