ID U5E4V4_NOCAS Unreviewed; 730 AA.
AC U5E4V4;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Putative carbonic anhydrase {ECO:0000313|EMBL:GAD84527.1};
GN ORFNames=NCAST_24_01330 {ECO:0000313|EMBL:GAD84527.1};
OS Nocardia asteroides NBRC 15531.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1110697 {ECO:0000313|EMBL:GAD84527.1, ECO:0000313|Proteomes:UP000017048};
RN [1] {ECO:0000313|EMBL:GAD84527.1, ECO:0000313|Proteomes:UP000017048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 15531 {ECO:0000313|EMBL:GAD84527.1,
RC ECO:0000313|Proteomes:UP000017048};
RX PubMed=24884595; DOI=10.1186/1471-2164-15-323;
RA Komaki H., Ichikawa N., Hosoyama A., Takahashi-Nakaguchi A., Matsuzawa T.,
RA Suzuki K., Fujita N., Gonoi T.;
RT "Genome based analysis of type-I polyketide synthase and nonribosomal
RT peptide synthetase gene clusters in seven strains of five representative
RT Nocardia species.";
RL BMC Genomics 15:323-323(2014).
CC -!- FUNCTION: Catalyzes the reversible hydration of carbon dioxide to form
CC bicarbonate. {ECO:0000256|ARBA:ARBA00024993}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the beta-class carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00006217}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD84527.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BAFO02000024; GAD84527.1; -; Genomic_DNA.
DR AlphaFoldDB; U5E4V4; -.
DR STRING; 1824.SAMN05444423_10614; -.
DR eggNOG; COG0288; Bacteria.
DR eggNOG; COG0659; Bacteria.
DR Proteomes; UP000017048; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 3.40.1050.10; Carbonic anhydrase; 1.
DR InterPro; IPR001765; Carbonic_anhydrase.
DR InterPro; IPR036874; Carbonic_anhydrase_sf.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR PANTHER; PTHR11814:SF227; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF00484; Pro_CA; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SMART; SM00947; Pro_CA; 1.
DR SUPFAM; SSF53056; beta-carbonic anhydrase, cab; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017048};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..371
FT /note="SLC26A/SulP transporter"
FT /evidence="ECO:0000259|Pfam:PF00916"
SQ SEQUENCE 730 AA; 75566 MW; B7C7C60C168F50E9 CRC64;
MTDNDPPRAS LKSLLQHDLP ASVVVFLVAL PLSLGVALAS GAPVVAGLIA AAVGGVVAGL
LGGSSVQVSG PTASLAVVVA AAVQQFGWAA MCFITVGAGL LQILFGLSRI ARAALGIAPV
VVHAMLAGIG VIIALQQVHV LLGGDTVSST WASIVALPQQ VMSVHKGDLF VGLLVIAVLI
GWQYLPRRVR LVPGPLVAVV TATVVSLILP LSVDRVRLDG SLLDGIGLPA LPHGGWVPIL
LTMLTVALIA SVETLLSAVA VDKMRPRQRT DFDRELLGQG AANMASGLLG GLPIAAVIVR
SITNANAGAR SRAATVLHGC WILVFAIALV GLVRQIPTAA LAGLLVLIGV QLVKLAHIKR
ARRTGDLYVY LVTVLAVVFL NLLQGLVIGL VASFALLLWR FVKCGIAATA RPDGSWLVRI
DGTCTFLAVP KLTGELAKVP AGAGVTVELS VDFLDHAACE LLSEWASHRE TAGGAVDFVE
LGTARMARAQ DGPPEHGQAR KAVDEALRPW RRSGGVDPIA AGITAYHRGH AHLVRPHLAG
LRHRPDADTF FLTCADARIV PNVITSSGPG DLFTVRNVGN LVPVGGSDVS VEAALIYALD
KLDVRAVVVC GHSGCGAMEA LYGQVQAGPG LDDWLAHAVP TLAAFHAGHP VAEAARQAGF
GPIDQLGMVN VARQVQTLID YPAVRSGIVQ RGVAVSGLFF DLATARVIEV TVDGIAEFDD
AGSRVAAEPV
//
