UniProt: U5EFV5

Database: UniProt
Entry: U5EFV5_NOCAS

LinkDB:  U5EFV5_NOCAS 
Original site:  U5EFV5_NOCAS

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Ontology (8)   
   GO (8)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (26)   
   InterPro (16)   
   Pfam (5)   
   PROSITE (3)   
   SMART (2)   
Literature (1)   
   PubMed (1)   
All databases (37)   

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ID   U5EFV5_NOCAS            Unreviewed;      5399 AA.
AC   U5EFV5;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN   ORFNames=NCAST_32_06720 {ECO:0000313|EMBL:GAD86185.1};
OS   Nocardia asteroides NBRC 15531.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=1110697 {ECO:0000313|EMBL:GAD86185.1, ECO:0000313|Proteomes:UP000017048};
RN   [1] {ECO:0000313|EMBL:GAD86185.1, ECO:0000313|Proteomes:UP000017048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 15531 {ECO:0000313|EMBL:GAD86185.1,
RC   ECO:0000313|Proteomes:UP000017048};
RX   PubMed=24884595; DOI=10.1186/1471-2164-15-323;
RA   Komaki H., Ichikawa N., Hosoyama A., Takahashi-Nakaguchi A., Matsuzawa T.,
RA   Suzuki K., Fujita N., Gonoi T.;
RT   "Genome based analysis of type-I polyketide synthase and nonribosomal
RT   peptide synthetase gene clusters in seven strains of five representative
RT   Nocardia species.";
RL   BMC Genomics 15:323-323(2014).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAD86185.1}.
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DR   EMBL; BAFO02000032; GAD86185.1; -; Genomic_DNA.
DR   RefSeq; WP_022566899.1; NZ_VBUS01000002.1.
DR   STRING; 1824.SAMN05444423_102436; -.
DR   eggNOG; COG1020; Bacteria.
DR   OrthoDB; 4501954at2; -.
DR   UniPathway; UPA00011; -.
DR   Proteomes; UP000017048; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 3.
DR   CDD; cd19543; DCL_NRPS; 1.
DR   CDD; cd19540; LCL_NRPS-like; 1.
DR   Gene3D; 3.30.300.30; -; 4.
DR   Gene3D; 3.40.50.980; -; 6.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 7.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR   NCBIfam; TIGR01720; NRPS-para261; 2.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 4.
DR   Pfam; PF13193; AMP-binding_C; 4.
DR   Pfam; PF00668; Condensation; 6.
DR   Pfam; PF00550; PP-binding; 4.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 4.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR   SUPFAM; SSF47336; ACP-like; 4.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR   PROSITE; PS00455; AMP_BINDING; 4.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017048}.
FT   DOMAIN          529..603
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2279..2353
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          4007..4082
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          5064..5139
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   5399 AA;  567465 MW;  1EA4D145481C5662 CRC64;
     MGEVRRATRG RGNRKASAPL FAQLLTAAVD TAGDAIAITY SPADGGARRE LTYTELDAAS
     SRLARELLDR GVGPGDVVAL GFTRSVESVL AVWAVAKAGA AYVPVDPGLP AERIAYLVAD
     SGAVLGLTGT AHAPVLGESL EWLAVDSPAV RDRIADRPAH PISYVDRVRP LTDQHPAYVI
     YTSGSTGRPK GVVVTHAGLG ALVTAARERY AVDARSRVLH VCSPNFDVSV LELLVTFQTG
     ATLVVSPPTV FGGPELAALL HREQVTHVLI TPAALESVDP RGLDALRVVV VAGDAFGPAL
     VRRWAVGERA FFNGYGPTEA TILATGSAAL LPDEPVTIGA AFPGVGAMVL DARLRPVPAG
     VAGELYLSGP ALAQSYLGRP GLTAERFVAA PFGGVAGARM YRTGDLVRRT SEGEFEYLGR
     SDFQVKVRGF RIELGEIDAA VSAHPEVAFA ATVGVTADSG ATVLVSYVLA RDGVSVDPEE
     VVRFAGAALP GHMVPSVVVV LDEIPLTPNG KLDRRALPVP VFGAVGSRAP EGPVEIAIAE
     LFTQILGLTE IGAEDSFFAA GGDSILSIQL VSRARNVGIA FTPQDVFEHR TVAGLARVAV
     VGAEAGPTLA ELPGGGVGAM PLTPVLAASV AGGRAFARFS QQMVLALPAG IDRHALTGTL
     RAVLDHHDML RAALRPVDGG GWELTALPPG AVPVDELLTR VDIPAGRSAE ERAEIAAAAL
     DAALAALDPA AARMVAFVWL CRADGPDGLV VAVNHAAIDG VSWRIVLSDL VAAWAQYAAG
     RRVVLPEVGT SFRRWAHGLS EAAPARRDEL EYWRRVLAVP DPLLGDRPLD PAVDTASAVR
     TFGVSVSAEV SRAVLTELPA VYRAGAEDGL LAALALAVRT WRARRGVDVS ATRVRLEGHG
     REATAVPGAD LTRTVGWFTS MYPVALELDG IDTEAAWAGG VATAALVKAV KEQLLAVPHK
     GIGFGMLRQL DTESAGQLDG SLGQIGFNYL GRISAGDVPG EAGEMAWLPT EEWGEPVAAQ
     DPALPAAAVI DINALATGSG AEVRLRASFS YVAGLVDEAS VRELAECWTA ALSVLAEHLR
     GPAAGGLSPA DVALVRVTQA ELDGWQRERA GLVDVVPLAP LQLGLLFLAQ VSEGSDPYLV
     QLAVELAGAV DLARLRRAAQ SVLDRHAILR TAFGATADGT PVGFVVEGAV VPWRVVDTEV
     SAARELLAAE ARIGFDLTAP PLLRFTVYRR DGGLQLVLTA HHLLVDGWSM PLLMKELLVA
     YAVDGGPSPL PPVRPYRDYL AWLHRQDRDA ALRGWRTALA GHVPTMVTGA VLPPADPVPG
     YGLCALELSA AEAEVLGAAA AAHEVTVNTL FQAAWGVVLA GALGRADVLF GAVVSGRPPQ
     LDGVDAMVGL FANTIPVRVR IDGGVSLGAL LARVQSDQVA VLAGHQVGLT EIQRVAGAGE
     LFDTLMAYES YPVDTEGMRQ AHGSIDGLEI VGVEAANATH YPVAVGVEVG DGIRVGVQYR
     LDSVGPEVAQ ALSDRLRAVL DAVVHTPDEP VASLLEAVPG DAIARTAYWR SVLTDLPADL
     NLPTDRPRPA GPVVVEDRVG FRIPAESHWR MLDLASAGET TVFTVVHVAF AVLLARLSGS
     TEIVVGTPGA GAGADTVVCR LPVPGDRAFA DLVADAAVVA RRAFTYPALT AAERSVLGVE
     AAPPRVLLLT ESRPGAGSPQ CDLALRLFAD PDGGIAAELG YARALFDRGT VSVFAERLVR
     LLVAALAAPD TAVGDLAMLS AGERSALTAR PEAAVPTGVL FPDLVARGVA LGRDRVAVRA
     GGRSVSYGEL DEYTSRLARE LIARGVGAEV PVAVVLPRSY EMVAAALAIA KAGGVYVPMD
     PAAPAQRLRH LITDAGAGVG LTMSAHRDRV PDSVTWSILD DPAFERSCVD RAADPVTDAD
     RSAPLRAQHP AYVIYTSGST GLPKGVTVTH AGLGPLVGEA RTRYGVRAEH RFLHICAPWF
     DPSVLEWLCA FSVGATLVVV PSEVIGGVEL TELLAGEGVT HAIITPAVLG TLDPAGLDQL
     AVLSVGGDVT TPELLTRWQP GRRYFNGYGP TETTIISTYA ELVAGQPVSI GEPVEGTHAV
     VLDARLNPVP PGVTGELYLA GPGLARGYHG QPGATGARFV ADPWGDPGAR MYRTGDLVRL
     RAGLLDYVGR VDTQLKVRGF RIEPGEVDAA LASRPEVATV VTVGRATVSG STTLVSYVIA
     APGHTADPAV LTTFAAECLP SYLVPSAIMV LDALPLTSNG KIDRAALPEP TACAAVDRAP
     CGDTETRVAE LFARVLGVTT VGVDDSFFAI GGDSILSIQL VSLARTAGIV FTTRDVFEHR
     TVAKLSAIAS VAGPSAPTLA ELPGGGVGTV PLTPVLADFL AGGSSDRFAQ TMVLALPDGI
     DRAGLVAVVA AVLDRHDMLR ARLRPAGTGW RFEVLAPGAV DADALVTEVD ADGTDLTRVG
     TAAMDTALSA LDPAEARMIA FTWIRRDDAP DVLAVAAHHY VIDGVSWRIL LPDFVVAWAQ
     YAAAQPIALP PVGTSFRRWA HALAETDRTA ELGYWQRLLA TPDPLLGRRA LDLALDTQST
     LRSLTVEVDP AVTEPLLSTL PARYRAGADH ALLAALALAV RNWRARRGVA AAAVRIRREG
     HGRTEQVVPG ADLTRTVGWF TSVHPVVLDL TEMAAGNLDD DTLAAAIRVV KEHLATVPDH
     GIGYGLLRTH PDTRELLSGD SGQIGFNYLG RATTAGEATG AAWLPTSALG DIEVDHDPAL
     PAHTVLDVNA IAVTTGSGLG LRADFRYATG ILDHDDVREL ADEWVRCLSA LAVHAEHPDA
     GGLTPSDVEL VRVTQADLDT WRRTHPGAVD VLPLSPLQHS LLALGELLDE SVHAYVIQLV
     ADLTGELDIA RLRRAAQTVL DRHANLRSAF VTAADGTPVQ VVAETVEAPV RVVEEVGEDQ
     LPELLAADQR AGFDPALAPL LRFTVYVTGS GRSHLVLTGH HILLDGWSMP LLMKELLVLY
     ATGGDATALP AVRPYRDYLA WLTRQDLAAA EDAWSRVLTG VTPSMLAPEL TWPAATGDGF
     GLCEFEFDTA RTAELTAFAA ATEVTANTVF QTAWGLVVAG STGRDDIVFG ATVSGRPPQL
     DGVGDMIGLF VDAVPVRVRL APGGTVGDLV RAVQAEQAGL LDHHHLGLGA IQRAAGLGEL
     FDTMLAFESF PVDAEGLQQA GGALGDLRID DLQGADFTHY PITVLVFLGA RTRVQIKYRR
     DLVSDATAQA VTDRLRTTLG DLIAAPGTPA AGITDRFART VTDPMTRSRF WRETLADLPG
     RLALPADDLE PGRRGTARVP LGSAADLRAL AATSGVSPTT LLRTALAVLL ARLTGTGDIV
     VATTLPDDRD MVVRTGIDLT TGFADLLGPD HLAETAAIEH AGITPAELAV LLGGDQGCLG
     QVSLDFQRPP NRHSDLALAV TDDDLEVSTV LGDDHAAQVF GERLAGILTA FGRHPGIAAG
     DLPICDTDEA AFLARIGDGG VPAAAGTLPA LLVRGTGFGQ HRIAVRDAGR GYTYGTLDAE
     SSRLARVLIA QGVGPETVVA SAIPRSYHSI LALWAIAKAG GVYLPVDPNY PADRVRHMLA
     DSGATVGLTV ADRAAGLPGS VRWLVLDDPA VRADVAARAS TTVRDRDRRV PLRREHAAYV
     IYTSGSTGVP KGVTVTHAGL GALLTHSAAL MWLRHDHRML HVCSPSFDQS VEEIGTAFHC
     GATLVVAPPD TVGGAELAEL LRTERVTHTI ITPALLGTLD PAALPELECV SAGGEASSAE
     LLAAWQPGRR FLNGYGPTEA TIGASYATLC AGDRVTIGPP VPGVRATVLD PRLRAVPVGV
     VGELYLAGDA LARGYRGRGA ATADRFVACP DSPGARMYRT GDLVRWVRGS AGAYALEYVG
     RSDFQVKIRG FRIEPGEIDA VLTRHPQIGF AVTVGAENPA GETTLVSYVT GRDIDPDGVV
     RWSAAVLPAH LVPAAVVVLD RIPLTASGKL DRKALPAPVF AARAYRAPST ETERTVAAVF
     AEVLGTERVG ADDNFFDLGG NSLLATRLTA RLGAAVDLRV PVRVLFAAPT VATCAAEIAR
     LSRASRRPAL SAGPRPDRIP LSPAQQRMWF LNRFDTATAA YTIPVVLRLH GALDIDALRA
     AFADVIARHE ILRTVYPVPD GTPVQVVLPV DHPDVPRLGF RTADDAEPAV RELVSAAFDV
     TAEVPLRATL LETAPREFVL AMAIHHIAGD GFSGGPLTRD LVTAYRARTT GRAPAWTPLP
     VQYADYALWQ QTLLGTDADP GSVGAEQIAY WRQALAGLPD QLDLPRDRPR PAVQSYAGGR
     VPFTVDAATH AALTELARAH SATLFMAVHT ALAVLLSGLS GTTDIAVGTP VAGRGDAVLD
     DLIGMFVNTL VFRTEVDSAA GFAELLTRQR EIDLRAFANA DVPFERLVEE LNPARSTARH
     PLFQVGLSFQ NLAEVRMDLP GISVTSVELD RDLSQFDLHL ILADRYTADG AAAGITGYCT
     YATDLFDEST VRGFLDRFTR VLTAVVRAPG AALHTIDLLA PAERTRIVQR WNRTTRHPGP
     AATLATLLDA TVAAHPDATA LVAGDLRWSF TELRARVNRL ARCLIAVGVG PETRVALAMR
     RSPDLVVAMY AVSVAGGAYV PIDPDQPATR TGHILDTATP LLVLTDAATG FDTATTPVVT
     VDELDLTGYG AAPLTDAERV APLSPANTAY VIFTSGSTGR PKGVAVSHAA VVNQLRWKTE
     RFGLTATDVV LLKTAATFDL SVWEFWSTAV CGARLVVAAP DGHRDPAYLA ELLRREEVTT
     LHVVPSMLDA LLTETLPGSL RRVLAIGETL PVALARRFAA AAPNMTLFNV YGPTEAAVSI
     TSHRVGATDT VTVPIGKPVW NSQVYVLDAW LRPVPVGVPG ELYLAGAQLA SGYLGRPDLT
     AERFVANPFQ PGTRLYRTGD VAVWNGDGEL EYRGRTDFQT KIRGFRIELE EIDAVLGAHD
     DVGFAVTVGR ENQAGETVLV SYVVAAGDRT VTVDALLDWA ARTLPAHMVP ATVVVLDRIP
     LTHVGKVDRA ALPAPELAAR TYRAPATAIE QTVCDVFADV LRLDRAGLDD HFFELGGTSL
     SATRLAAQLA EAVAAPIPVT WIFTTPTPAG LLATLRAGGA DSTGTEAAFG MLLPLRPSGT
     RAPLFCVHPI SGVAWSFSGL AAHLDPERPL YGLQSPALSS GEPLPDSIEE WARLYIKQIR
     EVQAEGPYHL LGWSLGGVIA HAMAVQLQAD GEEVAVLAML DSTLTAAAPA AVPARVTAAD
     LLGGFSGTQL GDDTLDAQTL AKALTELTGA TTALDATRID RILDAATASA TLDAAYRPRR
     FTGDISYFTA AQDDPTGTTN ADSWTDALTG TVRNHAVDAT HWRMTDPTAL ATIAAALQL
//

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