ID U5EP41_NOCAS Unreviewed; 5288 AA.
AC U5EP41;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Putative polyketide synthase {ECO:0000313|EMBL:GAD86849.1};
GN ORFNames=NCAST_33_02290 {ECO:0000313|EMBL:GAD86849.1};
OS Nocardia asteroides NBRC 15531.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1110697 {ECO:0000313|EMBL:GAD86849.1, ECO:0000313|Proteomes:UP000017048};
RN [1] {ECO:0000313|EMBL:GAD86849.1, ECO:0000313|Proteomes:UP000017048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 15531 {ECO:0000313|EMBL:GAD86849.1,
RC ECO:0000313|Proteomes:UP000017048};
RX PubMed=24884595; DOI=10.1186/1471-2164-15-323;
RA Komaki H., Ichikawa N., Hosoyama A., Takahashi-Nakaguchi A., Matsuzawa T.,
RA Suzuki K., Fujita N., Gonoi T.;
RT "Genome based analysis of type-I polyketide synthase and nonribosomal
RT peptide synthetase gene clusters in seven strains of five representative
RT Nocardia species.";
RL BMC Genomics 15:323-323(2014).
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DR EMBL; AB685274; BAO99035.1; -; Genomic_DNA.
DR EMBL; BAFO02000033; GAD86849.1; -; Genomic_DNA.
DR RefSeq; WP_019048597.1; NZ_VBUS01000001.1.
DR STRING; 1824.SAMN05444423_1011811; -.
DR eggNOG; COG3321; Bacteria.
DR Proteomes; UP000017048; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08956; KR_3_FAS_SDR_x; 3.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF21089; PKS_DH_N; 3.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 3.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00826; PKS_DH; 3.
DR SMART; SM00822; PKS_KR; 3.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 6.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 3.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000017048};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 38..465
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1687..1762
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1779..2191
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3398..3473
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3491..3908
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5137..5212
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 4777..4809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5253..5272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5288 AA; 547640 MW; 37AE5CCD1733F0F4 CRC64;
MSNPGSSNEE RLSRYLRKLT GDLRAAKKHI DQLEERASEP IAIVGMSCRY PGGVETPAQL
WDLLAGGTDA VGPFPADRGW DLERLFDPDP DAAGTIYTRE GGFLYAAGEF DAGFFGIGPR
AAEAMDPQQR LFLEAAWEAF EDAGIDPVSL RGSDTGVFAG VIHQDYGPRV GSPGLTAEAE
GNAYPGVSAS VLSGRVSFTF GLKGPALSVD TACSSSLVAL HLACQALRQG DTSLALVGGV
TVMSDPTLLI AFGRQRALSP DARCKAFAAA ANGTGFSEGL GMLVVERLSD ARRHGHRVLA
VVRGTAVNQD GASSRLTAPN GPSQEKVIAQ ALANAGLTPA DIDAVEAHGT GTTLGDPIEA
QALIAAYGTG RTGDPLRIGS LKSNIGHTSA AAGVGGVIKM VQAMRHEMLP ATLHVDEPTP
HVDWSAGTVR LLTAAEPWPA GERVRRAGVS SFGASGTNTH VILEEAPEFA AEPPGEDAPA
VVSAAVTPVL VSAKTEAGLR AQAAKLREWA IEHPTLSVEE LGYSSIATRA RLEWRGAVVA
ADRDALITGL AALAQDGAAA AAVGRKVAFL CTGQGAQRAG MGRELAQAFP VFATALGEIC
AEFDPLLGVS LQELMFTGGA EALNRTEFTQ PALFAYEVAV ARLWESFGVT PDVLLGHSIG
ELAAAHLAGV WSLPDACRLV AARGRLMGQL PGGGAMLAVA AGESEVVAAL AEVTGAASIA
AVNSPTSVVV SGDEDAVAAV ERHFAGRKTT RLTVSHAFHS HRMDPMLAEF EAVARQVTYH
RPQVPVVSNV SGQPAGDEIL DPAYWVRQVR AGVRFAEGVD AVVATGARRF LEIGPDAVLT
AMTRQCLDAE VDAQSLVVAA ARRGQDEVEQ FVRAVAAAEV VGVDIDWTSF FAGRPVTRVP
LPTYAFQRRR YWLETTAGSA DVAWAGLGAV RHPLLGAVVS EPESGGVLLT GRLAIATQPW
LADHVVAGSI LLPGTGFVEL ALRAGAEAGC PVLDELTLQA ALVLPASGGV QIQVVVGGAE
ADSPTRTVAI YSRAENEHDG PWLLHARGRL TEQPGPVAPD LTAWPPAAAA LDVATGYESL
RAYGYDYGPA FQGVRALWRD GAEVFAEVAV DPDTGVHAEG FGIHPALLDA ALQTGLMAGA
LESAAGESPF ALADGQVVLP FAWQSVSLTA TEASALRVRL TPSGSAVTIT AVDEQGRPVL
SGSLTTRRMP LAQLAASAAA TPAAPILDLR WSPTGPAPAA PVTDLGHWDD LAPDAPVPPV
VVVEAGTGWA GTDSDVVPAT HTELARVLTI VQTWLDQDRF ATSTLLIATR GAIALPGEDL
TDLPGAAVWG LVRSAQTEDP GRIILVDTDT RIDAALATTI TAVAEPQTVL RAGIPHTARL
TRPTTDLTHT TASAEVDTAA ASFGTGTVLM TGGTGGIGPV VARHLVAEHG VRSLLLVSRR
GPEADGVERL CAELTELGGQ VRVVACDIAD ATAVAGLLGE VPEQWPLTAV IHAAGVLDDG
VVAALTAERI DAVLAPKADA AWHLHQATAG LELAAFVVFS SASGTVGGPG QGNYAAANTF
LDALITHRRA RGLAGQSLAW GLWARSSGMA GQLGQTEVAR MSRTGFTAMP DERALAGWDA
AVARGAAHTV VAVLDTAAIR AQADAGLLPP LLRELAPATA RRATATSAAP SGLRGRLAGL
DTDRQRQLVL DTVRTHIAAV LGHDSVAEVD PGRAFSELGF DSLSAVELRN RLKTVTGLSL
STTVVFDYPT PQALADHVAG EFLGATAELE LGTGQSLDDD PIAIVGMACR YPGGVSSPED
LWRLVDDGVD AASHFPINRG WDTDRIYDPS GETPHTTYTR EGGFLHGAGE FDPGFFGISP
HEAASMDPQQ FLLLESSWEA FERAGVDPAV LRGSATGVFT GMMYHDYAGN ANAGSIASGR
VSYVLGLEGP SVTIDTACSS SLVAMHLAAQ SLRSGECDLA LAGGVAVMAT PETFVEFSRQ
RGLSPDGRSK SFADAADGVA WSEGVGVLVL ERLSDARRNG HPVLAVVAGS AVNQDGASNG
LTAPNGPSQR RVIRRALANA GVRAADVDVV EAHGTGTTLG DPIEAQALLA TYGQDRDPAR
PLWLGSLKSN IGHAQAAAGV GGVIKMVMAM RHGVLPRTLH VDQPSTKVDW SAGEVRLLTE
PVAWPEVDRP RRAGVSSFGI SGTNAHVIVE QAPPPPDSPT EPEIIAPGVV PWVLSARGGD
ALAEQAARLA ALVTASEPDP ADIGFSLAAT RAVFEHRAVL VGADRDELLT GVRALAAGDA
ATGLVTGRAL PGSTGVVFSG QGAQWARMAQ DLRAAYPVFA EHFDGIVEWL EPLLAQPESL
ADALADDALV DRTVFAQAGL FAFEVALYRL LESWGFRADV VAGHSIGEVA AAHVAGVLTL
ADACALVAAR GRLMQALPAG GAMVAVGAAE AEVLELLTGE VSIAAVNGPA SVVLSGAEDA
VLAVAEACAE RGWRTHRLRV SHAFHSALME PMLAEFAAVV AGVTFAPPTL ELVSTATGNR
IDEEMTDPGY WVDQLRGTVR FAAAVTTMTQ LGVARFAEVG PDAVLTPMLT QVDAAVAALA
RRERADAPAL LSGLAALFVA GAELDWARVF AGSRARRVDL PTYAFQHDRF WLDAKQALAN
SWIGAELGGV AAVGLDTVDH PLLGAAVPHP ESGAVSFTGR WSVDTVDWLA DHSVLGVVLL
PGTGFVELAA HVGGLLGCPT VDELVLHTPL TLPAEGSVAV QVVVAAADDA GRRRLSVHSQ
QTGDGPWAIH AEGILAPSDP VAAFDLTAWP PAGAQPLPVD TAYDELLEVG YGYGPYFQGL
RAAWQRGDEL FAEVALPDSR AADGYGIHPA LFDAALHAGI IHGLRGGVDG FPALPFTWNQ
VTVHAAGAAT VRVRITLEGT RFGIQIADEQ GSPVLSVGAL VSRPVSAERL GADRVADALF
GVDWVAVTPT TAAVDTNRVA LLGSTETTKV RGYPDLAALT AELDATDAVV PDVVLLTTPD
HDGPAPEAAR RIVADVLGTL QDWLADTRWA ATRLVVLTRN AVHDTVDLSQ APVWGLVRAA
QAEHPGRIQL LDLDTDGDPL AAAAAAATGE PEAALRGTTL LVPRLTRRTP APADGPIEPG
TVLVTGGTGG LGAVLARHLV TDHGVRHLLL TSRRGPDAPG AAELVAELTG LGAEVTVTAC
DVTDRDALAA VLAAIPADRP LVGVVHAAGT ADNGLIASIT PDRLAHVFRP KADAAWHLHE
LTRDRALSLF VLVSSAGGLV LPAGQANYAA ANVFLDALAA HRHGLGLPAL ALDYGMWARA
TGLGAELSDR DFDRMRRQGF PPLTETEGLA LFDAALGAGA AQLVPLRIDP AVLRTRGDQI
PALLRGIVPA PVRRVTRTAA GQAFLRKLAG LSDADRGSAL LDLVRSVAAE ILGHTSVEAI
EPHQPFQQLG FDSLGAVEFR NKLNAATGLQ LPATLLFDYP NPQVVAEFVE AQLTGVGAVA
EVAVSRVRAD DEPIAVVAMS CRYPGGVASP EDLWQLVTSG GDTTGPMPLD RGWDIDGIYD
PEPGKAGKTY TRSGGFLYEA AEFDAGFFGI SPNEATVMDP QQRVLLEVSW EALERAGLDP
AALRGSATGV FTGVMYHDYA QGTGTGSSAA GSLVSGRVSY VFGLEGPSVT VDTACSSSLV
ALHLAAQSLR SGECELALAG GVAVMATPDM FLEFGRQRGL SPDGRCKSFA DDADGVGWSE
GAGVLVLERL SDARRNGHQV LAVLAGSAVN QDGASNGFSA PNGPSQQRVI RQALANAGVS
PVDVDAVEAH GTGTTLGDPI EAQALLATYG QDRALDRPLW LGSLKSNIGH AQAAAGVGGV
IKMVMALRHG VLPRTLHADE PSTKVDWNEG HVRLLTEAVP WPDTDRPRRA GVSSFGISGT
NAHVIVEQAP AVADPVTERG VPAGGFVPWV LSARTAEALA DQAARLVAAA QDTEPVDVGF
SLASTRTVFE HRAVVLAEDG AGLLAGASAL ATGAQAAGVI TGRVTTGSAG LVFSGQGAQW
AGMATDLRAA FPVFAENFDG IVAQLEPQLG QSISLTEALS DDAALARTVF TQAGLFAYEV
ALFRLLESWG VKPDVVAGHS IGEIAAAHVA GVLSLTDACA LVAARGRLMQ ALPAGGAMVA
VGAPEADVLE IAALLDTKVS VAAVNGPASV VLSGLDAEVT AVIERCAERG WRTHRLTVSH
AFHSVLMEPM LDEFATVVRG LTIHRPDITL VSTVTGARVT EEMTDPSYWV GQVRDTVRFA
DAVTTMAALG VTRFAEVGPD AALTPMVAQT LDTATAVALT VRKHAHTATL LTGLARLYVA
GTAVDWARLY AGTGARRVDL PTYAFQRTRY WMTEATAGGG DARSMGLTAT GHPLVSAVIA
QPDSAGVILT GRLATSTHPW LADHRVHDAV VFPGTGLVEL ALHAAGQVGC ATVDDLVLQA
PLVLQEPGGS ALRVVVGDRD DTGRRPLRIF SSPDDGDPVW TLNAEGTVRP ADTATGADLV
AWPPADARPL PIDDGYAGLS AAGYGYGPFF QGLRAAWRRG DEVFAEVALP DARLADGFGL
HPALFDSALH ALLLAEEIPT AGTALALPFE WSGVTLHAAG ATALRVRMTR VGEHGVVLDL
ADAAGAPVAT VRHLASRPMD PAQLVLGASA VGNALFDVGW TPITLSGTAI DTAPWAEPGD
TIPPVVILDC PAGNDAAAVR AATHQVLHAV QSWLTEPRFA DSVLVVRTSG AVSVAGEDIT
NLAGAAVSGL VRAAQSEAPG RIILVDIDSE RAQVESLPFA DSGRPSGELL GAGRAPSEPA
PDSVASRIPG DDLSRDLGSL LGPVLGTGEP QVAVRGGIVH AARLRRIDTA ALGSAQAPAY
DPADTVLITG AGGALAGLFA RHLVAEHGVR HLLLLSRRGE SAPGSAELRA EVTEAGADVR
FAACDVTDRG ALARVLADIP GDQPLAGVYH LAGVLDDGAI ASLTPERLDT VLGPKVDAAL
HLHALTADLP VKAFVLFSSA AGAFGNTGQG NYAAANACLD ALAAHRRATG RAGQSLAWGL
WDGGMAGELG DVDRLRMART GMLPLSRAQG LALFDAAARL DVAAPVLARM NLDVMRDAGF
APALLAGLTT PRRKVTDGTA AALRARLAAT LAGERLDVLV DLVRGQVAHT LGHGNAAVVE
AGKAFNDLGF DSITALEFRN GLNAATGLAL PATLVFDYPT PAALGEYLHE ELTDGDEPQP
VDLPDDDIRR ALQTIPLARL REAGLLDALL RLTDEPDSPA DTPPADPADA IDDLDLDDLI
DLAFHSED
//
