ID U5EQK0_9DIPT Unreviewed; 472 AA.
AC U5EQK0;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 08-NOV-2023, entry version 39.
DE RecName: Full=Histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184, ECO:0000256|RuleBase:RU361211};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184, ECO:0000256|RuleBase:RU361211};
DE Flags: Fragment;
OS Corethrella appendiculata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Chaoboridae;
OC Corethrella.
OX NCBI_TaxID=1370023 {ECO:0000313|EMBL:JAB55662.1};
RN [1] {ECO:0000313|EMBL:JAB55662.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary glands {ECO:0000313|EMBL:JAB55662.1};
RA Ribeiro J.M.C., Chagas A.C., Pham V.M., Lounibos L.P., Calvo E.;
RT "An insight into the sialome of the frog biting fly, Corethrella
RT appendiculata.";
RL Insect Biochem. Mol. Biol. 44:23-32(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC Evidence={ECO:0000256|RuleBase:RU361211};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU361211}.
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107, ECO:0000256|RuleBase:RU361211}.
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DR EMBL; GANO01004209; JAB55662.1; -; mRNA.
DR AlphaFoldDB; U5EQK0; -.
DR GO; GO:0005694; C:chromosome; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR025995; Tudor-knot.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR040706; Zf-MYST.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF82; HISTONE ACETYLTRANSFERASE KAT8; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR Pfam; PF17772; zf-MYST; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 2: Evidence at transcript level;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Nucleus {ECO:0000256|RuleBase:RU361211};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:JAB55662.1}.
FT DOMAIN 186..458
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT ACT_SITE 362
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:JAB55662.1"
SQ SEQUENCE 472 AA; 54714 MW; CF3EFCA6D79C9FDD CRC64;
ELNLVIGEDY LVKRQDNTWH LAQIIQSRPH SIDPKELEYY IHYDGLNRRL DQWVTRERIM
KAPPKNTNLK ANAITTNGGV PANTTNTTVS ATNNFTTFGA ANVTGAAVGV NVKENKLHNV
YGKDETAAKL TDISLMDTSM DYGSESDRKI TRNQKRRHDE INHVQKPYSE MDPTTAALEK
EHEAITKVKY IDKLRIGKYE IDTWYFSPYP EEYGKVGTLY VCEFCLRYMK LRKTLKMHKT
SCLKRSPPGN EIYRKGTISI FEIDGKDHRF YCQTLCLMAK LFLDHKTLYY DVDPFFFYVL
CEIDKEGQHI VGYFSKEKES PEGNNVACIL ILPPYQRKGY GKLLIAFSYE LSRREGIIGS
PEKPLSDLGR LSYRSYWAYT LLELMREYRT TTVKELSELS GITVDDIIYT LQSMKMVKYW
KGQHVICVTQ KVVIEHLQLP QFKRPKLMID PVFLKWAPQK RTVPVKASMK KI
//
