ID U5LIV0_RATAR Unreviewed; 749 AA.
AC U5LIV0;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Toll-like receptor 4 {ECO:0000256|ARBA:ARBA00040109};
DE Flags: Fragment;
GN Name=Tlr4 {ECO:0000313|EMBL:AGX25462.1};
OS Rattus argentiventer (Rice-field rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=83752 {ECO:0000313|EMBL:AGX25462.1};
RN [1] {ECO:0000313|EMBL:AGX25462.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C0014 {ECO:0000313|EMBL:AGX25461.1}, and C0048
RC {ECO:0000313|EMBL:AGX25462.1};
RX PubMed=24028551; DOI=10.1186/1471-2148-13-194;
RA Fornuskova A., Vinkler M., Pages M., Galan M., Jousselin E., Cerqueira F.,
RA Morand S., Charbonnel N., Bryja J., Cosson J.F.;
RT "Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and
RT Tlr7) in wild rodents (MURINAE).";
RL BMC Evol. Biol. 13:194-194(2013).
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Early endosome
CC {ECO:0000256|ARBA:ARBA00004412}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KC811666; AGX25461.1; -; Genomic_DNA.
DR EMBL; KC811667; AGX25462.1; -; Genomic_DNA.
DR AlphaFoldDB; U5LIV0; -.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF521; TOLL-LIKE RECEPTOR 4; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 5.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AGX25462.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 545..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 584..727
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGX25462.1"
SQ SEQUENCE 749 AA; 86064 MW; 5CB769B3D6D21CA9 CRC64;
CEIETIEDKA WYGLHQLSTL VLTGNPIKSF SPGSFSGLTN LENLVAVETK LTSLEGFHIG
QLITLKKLNV AHNLIHSFKL SEYFSNLTNL QHVDLSYNYI QTISVKDLQF LRENPQVNLS
LDLSLNPIDS IEAQAFQGIR LHELTLRSNF NSSNVLKMCL QNMTGLHVHR LILGEFKNER
NLESFDRSVM EGLCNVTIDE FRLTYINHFS DDIYNLNCLA NVSAMSFTGV HIKHLADVPR
HFKWQSLSII RCHLKPFPKL SLPFLKSWTL TTNRADTSFG QLALPSLRYL DLSRNAMSFR
GCCSYSDVGT NNLKYLDLSF NGVILMSANF MGLEELEYLD FQHSTLKKVT EFSVFLSLEK
LLYLDISYTN TKIDFDGIFL GLVSLNTLKM AGNSFKDNTL SNVFTNTTNL TFLDLSKCQL
EQISWGVFDT LYRLQLLNMS HNNLLFLDPS HYKQLYSLRT LDCSFNRIET AKGILQHFPK
SLAVFNLTNN SVACICEYQN FLQWVKDQKM FLVNVEQMKC ASPIDMNASL VLDFTNSTCY
IYKTIISVSV VSVLVVATVA FLIYHFYFHL ILIAGCKKYS RGESIYDAFV IYSSQNEDWV
RNELVKNLEE GVPRFQLCLH YRDFIPGVAI AANIIQEGFH KSRKVIVVVS RHFIQSRWCI
FEYEIAQTWQ FLSSRSGIIF IVLEKVEKSL LRQQVELYRL LSRNTYLEWE DNALGRHIFW
RRLKKALLDG KALNPDGTSE EEQEATTLT
//
