ID U5LIZ7_BERBO Unreviewed; 1049 AA.
AC U5LIZ7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Toll like receptor 7 {ECO:0000313|EMBL:AGX25512.1};
DE Flags: Fragment;
GN Name=Tlr7 {ECO:0000313|EMBL:AGX25512.1};
OS Berylmys bowersi (Bower's white-toothed rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Berylmys.
OX NCBI_TaxID=83759 {ECO:0000313|EMBL:AGX25512.1};
RN [1] {ECO:0000313|EMBL:AGX25512.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=L0151 {ECO:0000313|EMBL:AGX25512.1};
RX PubMed=24028551; DOI=10.1186/1471-2148-13-194;
RA Fornuskova A., Vinkler M., Pages M., Galan M., Jousselin E., Cerqueira F.,
RA Morand S., Charbonnel N., Bryja J., Cosson J.F.;
RT "Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and
RT Tlr7) in wild rodents (MURINAE).";
RL BMC Evol. Biol. 13:194-194(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KC811717; AGX25512.1; -; Genomic_DNA.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0002218; P:activation of innate immune response; IEA:UniProt.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0001819; P:positive regulation of cytokine production; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410:SF2; TOLL-LIKE RECEPTOR 7; 1.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00365; LRR_SD22; 9.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 4.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AGX25512.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 840..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 889..1033
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGX25512.1"
SQ SEQUENCE 1049 AA; 121100 MW; BCE9FC9E5F4452AB CRC64;
VFPMWTLKRQ SFIFLNMILV SRVLGFRWYP KTLPCDVSLD STKTHVIVDC TDKHLTEIPE
GIPTNTTNLT LTINHIPSIS PDSFRRLNHL EELDLRCNCV PILLGSKANV CTKRLQIRPG
SFSGLSDLKS LYLDGNQLLE IPQDLPSSLQ LLSLEANNIF SITKENLTEL VNIESLYLGQ
NCYYRNPCNV SYSIEKDAFL VMKNLKVLSL KDNNVTAVPT ILPPNLLELY LYNNIIKKIQ
EDDFNKLSQL QVLDLSGNCP RCYNVPYPCT PCENNSPLQI HDNAFDSLTE LKVLRLHSNS
LQHVPANWFK NMTNLQELDL SQNYLAREIE EAKFLNSLPN LVQLDLSFNY ELQVYHASIT
LPHSLSSLRN LKNLYIKGYV FKELKDSSLS VLHKLPSLEV LDLGTNFIKI ADLNIFQQFE
NLKFIDLSVN KISPSEESRE VGFCPNAQTS VDQHGPQVLE TLHYFRYDEY ARSCRFKNKE
PPTLLPLNAD CHTFGQTLDL SRNNIFFIKP SDFQHLSFLK CLNLSGNTIG QTLNGSELRP
LRELRYLDFS NNRLDLLYST AFEELQNLEI LDLSSNSHYF QAEGITHMLN FTKKLRHLKK
LMMNDNDIST SASRTMESES LQILEFRGNH LDVLWRDGDN RYLDFFKNLL NLEELDISRN
SLNSLPSGVF EGMPPNLKTL SLAKNGLKSF SWGRLQLLKH LENLDLSHNQ LTTIPARLAN
CSKSLTKLIL NHNQIRQLTK YFLEDALQLS YLDISSNKIQ VIQKTSFPEN VLNNLNMLLL
HHNRFLCNCD AVWFVWWVNH TDVTIPYLAT DVTCAGPGAH KGQSVVSLDL YTCELDLTNL
ILFSVSISSX LFLMIVMTTS HLFLWDMWYI YYFWKAKIKG YQHLQSMESC YDAFIVYDTK
NSAVTEWVLQ ELVVKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS RKTVFVMTQK
YAKTESFKMA FYLSHQRLMD EKVDVIILIF LEKPLQKSKF LQLRKRLCSS SVLEWPTNPQ
AHPYFWQCLK NALTTDNHVA YSQMFKETV
//