ID U5ML29_CLOSA Unreviewed; 459 AA.
AC U5ML29;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Protein TldD {ECO:0000313|EMBL:AGX41489.1};
GN Name=tldD {ECO:0000313|EMBL:AGX41489.1};
GN ORFNames=CLSA_c04660 {ECO:0000313|EMBL:AGX41489.1};
OS Clostridium saccharobutylicum DSM 13864.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1345695 {ECO:0000313|EMBL:AGX41489.1, ECO:0000313|Proteomes:UP000017118};
RN [1] {ECO:0000313|EMBL:AGX41489.1, ECO:0000313|Proteomes:UP000017118}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13864 {ECO:0000313|EMBL:AGX41489.1};
RX PubMed=24285650;
RA Poehlein A., Hartwich K., Krabben P., Ehrenreich A., Liebl W., Durre P.,
RA Gottschalk G., Daniel R.;
RT "Complete Genome Sequence of the Solvent Producer Clostridium
RT saccharobutylicum NCP262 (DSM 13864).";
RL Genome Announc. 1:e00997-13(2013).
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; CP006721; AGX41489.1; -; Genomic_DNA.
DR RefSeq; WP_022743777.1; NZ_AYXL01000179.1.
DR AlphaFoldDB; U5ML29; -.
DR GeneID; 55473021; -.
DR KEGG; csb:CLSA_c04660; -.
DR PATRIC; fig|1345695.10.peg.1274; -.
DR eggNOG; COG0312; Bacteria.
DR HOGENOM; CLU_026425_1_0_9; -.
DR OrthoDB; 9803213at2; -.
DR Proteomes; UP000017118; Chromosome.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR025502; TldD.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR PIRSF; PIRSF004919; TldD; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000017118}.
FT DOMAIN 22..83
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 111..219
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 227..458
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 459 AA; 49291 MW; F43A3AC0F8F57E41 CRC64;
MLSKNIAQEV LAKCLATGGD FAEIFEDDSI NNSISLIDGR VENAIGGRTY GIGIRIFKGL
KSVYAYTNNN SLDSLLETAY SAALALGEIK EDKSIILNES KITTIHPIIY YPKDVAYEKR
ISILKSGYGA AKNYSDDISQ VVANYSDKQQ HILIANTEGL YIEDTRVRTR LGISAIASKE
NENQTGFEGP GAHKGIELFD TIDPEYYGKE AARVATTLLY AKNCPAGNMA VAIDNGFGGV
IFHEACGHAL EASSVSKGNS VFANKLGQQI ASTKVTAIDD GTIPNAWGSL NVDDEGNKTQ
KNVLIENGIL KGYMIDKLNG RRMNMEATGS SRRQSYKYQP TSRMTNTYIA AGTDKAEDII
KSISDGLYAK KLGGGSVNPV TGEFNFSVQE GYLVKNGIIQ EPVRGASLIG KGSEVLMDID
MVGDNLKLAQ GVCGASSGNI PTNVGQPMIR VKKMTVGGR
//
