ID U5NMN0_TRYBR Unreviewed; 463 AA.
AC U5NMN0;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 13-SEP-2023, entry version 24.
DE SubName: Full=Adenosine transporter 1 {ECO:0000313|EMBL:AGY30947.1};
GN Name=at1 {ECO:0000313|EMBL:AGY30947.1};
OS Trypanosoma brucei rhodesiense.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=31286 {ECO:0000313|EMBL:AGY30947.1};
RN [1] {ECO:0000313|EMBL:AGY30947.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=STIB900 {ECO:0000313|EMBL:AGY30947.1};
RX PubMed=24130910;
RA Graf F.E., Ludin P., Wenzler T., Kaiser M., Brun R., Pyana P.P.,
RA Buscher P., de Koning H.P., Horn D., Maser P.;
RT "Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates
RT Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol.";
RL PLoS Negl. Trop. Dis. 7:E2475-E2475(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
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DR EMBL; KF564952; AGY30947.1; -; Genomic_DNA.
DR AlphaFoldDB; U5NMN0; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR034764; ENT1/ENT2.
DR InterPro; IPR002259; Eqnu_transpt.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00939; 2a57; 1.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF82; TRANSPORTER 2, PUTATIVE-RELATED; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 236..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 51041 MW; D5A530192BA65D26 CRC64;
MLGFDSANEF IVYVTFLFFG MSVVVVTNSI FSMPFFFIEY YKYAQGKPDA KPEDPKFWKH
MFTYYSIAAF LVELVLASLM LTPIGRRISV TVRLGVGLVI PIVLVFSVMM VTIVTTTETG
AKVTIMLIAI ANGVAMTLCD AGNAALIAPF PTKFYSSVVW GIAVCGVVTS FFSIVIKASM
GGGYHNMLIQ SRIYFGLVMF MQVISCALLV LLRKNPYAQK YAAEFRYAAR KGIDDKGADG
DEGNGAAKGP ADQDDDPHGG DDTDKGNVMT ATVDPDTMKD MDQVENITTS QQMLMARVWN
VFWRVWPMLF ACFMVFFTTF LVYPAVYFAI KADTGDGWYL TIAAALFNLG DFLSRLCLQF
KALHVSPRWV LIGTFARMLL IIPLVLCVRS IITGPWLPYI LVHAWGFTYG YYGGISQIYA
PRTGSLTTAG ERSLAANWTI ISLLGGIFVG AMFALAVNEG LPK
//
