ID U5TAA0_COWPX Unreviewed; 564 AA.
AC U5TAA0;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=CPXV193 protein {ECO:0000313|EMBL:AGY97482.1};
GN Name=CPXV193 {ECO:0000313|EMBL:AGY97482.1};
OS Cowpox virus (CPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=10243 {ECO:0000313|EMBL:AGY97482.1, ECO:0000313|Proteomes:UP000168833};
OH NCBI_TaxID=10129; Apodemus sylvaticus (European woodmouse).
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH NCBI_TaxID=10090; Mus musculus (Mouse).
OH NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN [1] {ECO:0000313|EMBL:AGY97482.1, ECO:0000313|Proteomes:UP000168833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HumLit08/1 {ECO:0000313|EMBL:AGY97482.1};
RA Dabrowski P.W., Radonic A., Kurth A., Nitsche A.;
RT "Genome-wide comparison of cowpoxviruses reveals a new clade related to
RT Variola virus.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable substrate-specific adapter of CUL3-containing E3
CC ubiquitin-protein ligases which mediate the ubiquitination and
CC subsequent proteasomal degradation of host target proteins.
CC {ECO:0000256|ARBA:ARBA00003454}.
CC -!- SUBUNIT: Interacts (via BTB domain) with host CUL3.
CC {ECO:0000256|ARBA:ARBA00011677}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
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DR EMBL; KC813493; AGY97482.1; -; Genomic_DNA.
DR Proteomes; UP000168833; Genome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0039648; P:modulation by symbiont of host protein ubiquitination; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR024182; Vaccinia_A55R.
DR PANTHER; PTHR45632:SF3; KELCH-LIKE PROTEIN DIABLO; 1.
DR PANTHER; PTHR45632; LD33804P; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR PIRSF; PIRSF003716; VAC_F3L; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022489};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Modulation of host E3 ubiquitin ligases by virus
KW {ECO:0000256|ARBA:ARBA00022489};
KW Modulation of host ubiquitin pathway by virus
KW {ECO:0000256|ARBA:ARBA00022662}; Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 21..88
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 564 AA; 64792 MW; EBDEDCFFB0D429B3 CRC64;
MNNSSELIAV INGFRNSGRF CDINIVINDE RINAHRLILS GASEYFSILF SNNFIDSNEY
EVNLSHLDYQ SVNDLIDYIY GIPLSLTNDS VKYILSTADF LQIGSAITEC ENYILKNLCS
RNCIDFYIYA DKYNNKKIES ASFNTILRNI LRLINDENFK YLTEESMIKI LSDDMLNIKN
EDFAPLILIK WLESTQQSCT VELLRCLRIS LLSPQVIKSL YSHQLVSSIY ECITFLNNIA
FLDESFPRYH SIELISIGIS NSHDKISINC YNHKKNTWEM ISSRRYRCSF AVAVMDNIIY
MMGGYDQSPY RSSKVIAYNT CTNSWIYDIP ELKYPRSNCG GVADDEYIYC IGGIRDQDSS
LISSIDRWKP SKPYWQTYAK MREPKCDMGV AMLNGLIYVM GGIVKGDTCT DALESLSEDG
WMKHQRLPIK MSNMSTIVHD GKIYISGGYN NSSVVNVISN LVLSYNPIYD EWTKLSSLNI
PRINPALWSA HNKLYVGGGI SDDVRTNTSE TYDKEKDCWT LDNGHVLPRN YIMYKCEPIK
HKYPLEKTQY TNDFLKYLES FIGS
//
