ID U5W1G4_9ACTN Unreviewed; 4050 AA.
AC U5W1G4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Fibronectin type III domain-containing protein {ECO:0000313|EMBL:AGZ42862.1};
GN ORFNames=AFR_22960 {ECO:0000313|EMBL:AGZ42862.1};
OS Actinoplanes friuliensis DSM 7358.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1246995 {ECO:0000313|EMBL:AGZ42862.1, ECO:0000313|Proteomes:UP000017746};
RN [1] {ECO:0000313|EMBL:AGZ42862.1, ECO:0000313|Proteomes:UP000017746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7358 {ECO:0000313|EMBL:AGZ42862.1,
RC ECO:0000313|Proteomes:UP000017746};
RX PubMed=24637369; DOI=10.1016/j.jbiotec.2014.03.011;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Fischer N.,
RA Steinkamper A., Puhler A., Biener R., Schwartz D., Kalinowski J.;
RT "Complete genome sequence of the actinobacterium Actinoplanes friuliensis
RT HAG 010964, producer of the lipopeptide antibiotic friulimycin.";
RL J. Biotechnol. 178:41-42(2014).
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DR EMBL; CP006272; AGZ42862.1; -; Genomic_DNA.
DR RefSeq; WP_023363373.1; NC_022657.1.
DR STRING; 1246995.AFR_22960; -.
DR KEGG; afs:AFR_22960; -.
DR PATRIC; fig|1246995.3.peg.4653; -.
DR eggNOG; COG4733; Bacteria.
DR HOGENOM; CLU_224365_0_0_11; -.
DR OrthoDB; 5186542at2; -.
DR Proteomes; UP000017746; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 38.
DR Gene3D; 2.40.10.500; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 39.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001258; NHL_repeat.
DR PANTHER; PTHR13817:SF73; PROTEIN SIDEKICK HOMOLOG; 1.
DR PANTHER; PTHR13817; TITIN; 1.
DR Pfam; PF00041; fn3; 36.
DR Pfam; PF01436; NHL; 1.
DR SMART; SM00060; FN3; 39.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 22.
DR PROSITE; PS50853; FN3; 35.
DR PROSITE; PS51125; NHL; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023326};
KW Reference proteome {ECO:0000313|Proteomes:UP000017746};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4025..4045
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 241..272
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT DOMAIN 385..481
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 482..574
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 575..669
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 670..765
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 766..860
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 861..957
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 960..1051
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1052..1147
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1148..1244
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1245..1330
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1331..1421
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1422..1506
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1507..1595
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1596..1683
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1684..1774
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1775..1859
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1860..1947
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1948..2039
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2125..2215
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2216..2309
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2310..2395
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2396..2486
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2487..2571
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2572..2661
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2745..2839
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2840..2922
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2923..3010
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3011..3101
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3102..3195
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3197..3277
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3278..3367
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3452..3540
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3625..3715
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3717..3810
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3811..3898
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1131..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1494..1520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2022..2046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2731..2783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3882..3912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1131..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2028..2046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2755..2769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3882..3896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4050 AA; 392262 MW; E1F4898152153B0C CRC64;
MATALPRRVQ EWAMAVRRVS GPRRSVAMAA VVALAVLSSV IGLASPAAAA GGFVLSIYGG
TGAAAAPVAG PVSASPIGRP DAMTSDAAGN VYVYVRSACR VVKISPAGVL SPVAGSGTCG
TGSAGDALQS ALSTNVTSLA VDGSGNLFVG DSGSARIYKV TPGGTLSVFA GNGTVGATTN
GSATLSSVVP DSLAVDSTGT VFVGYVGRAS VLKITAAGAL TRYAGTGNAG LTLPGISTLA
NLNKPSSLAV DTSGNLYIGD TGNNRIYLVT TGQILSAFAG NGTTGSPVPG STSSPVPTPA
AMTFDSASTL YVAESSSRQI LSFTLSGNGA PSLVAGSGGT GTPNPGTATS SPLGTVTALT
ATAPSSLVVG DSTYNYLLRI AAPTAPDAPT GLSAVPGPSR AVLTFSPPAG NGGSAITGYE
VSTNNGTSWA ALTVTGSTTR TGTVTGLTNG TAYTVRVRAL NAIGNGAASA ATTVTPATAP
DAPYGLVVLA GDAAAALSFS PPLSNGGSAI TGYEVSTDTG SSWTPIATTA GLLGVRNGSV
TGLTNGISYT FQVRAANVVG AGPATAGVSA TPRGAPYAPT ALTATTGNAQ ATLTFTTPPD
GGNTILGYQV STDDGATWSG LVVSTSGTTN TATLTNLSNG TVYPVRVRAL NLAGAGVPSA
ATTVSLAALV PDAPTGLVAT AGDTTIGLSF APPASTGGSA LTGYEASTDN GTTWVPITTA
AGLLGVRTAT LTGLTNGTAY AVRVRAVNAV GPSPAGGSAA ATPRGAPYAP TGLTAVAGDR
QIGVTFTTPG DGGSAILGYQ VSTDNGATWS GLAVTTSGTT NTATVTGLTN GVAYTVKVRA
ASLLGTGAAS PGVPVVLQAL VPGAPTGLVA LAGDTTIALS FAPPATDGGS AITGYEASTD
NGTTWAPITT AAGLLGTRTA TLTGLTNGTT YAVRVRAVNA VGPGPAGTSV NATPKGAPYA
PTGLSAVAGN TQATVTFTTP RDGGNPILGY QVSTDDGTTW SNLAVTTSGT TNTGAVGGLT
NGTTYAIRVR AVSLGGTGAA SAGTAVVLPA LVPAAPTALF ATAGDTTISV SFAPPATNGG
AVITGYEAST DNGTTWAPIT TAAGLLGNRT ATLTGLTNGV TYTVRVRATN AAGASATSDS
TTATPRGTPY APAGLSAVPG NGQAVLTFTT PGDGGYPILG YQVSTDDGAT WTTLTVATSG
TDNTGTVTGL ANGTTYAIRV RARNLAGAGT PSAATAVIPA TVPGAPTAVA AAAGNTQITV
TFTPPAATGG RPITGYEVST DNGTTWAALP DSGLVTGLTN GVAYAVRVRA VNAVGAGTAS
ASTTVTPIPA TPDPPTGLAA ERGDRSALLT FTPPVMTGTS PISGYEVSTD DGTSWAALAS
DRRVTGLTNG TAYTIRVRAV NASGAGPAGA AVTVTPATLP GAPTGLTVTI GDTRAVLAFT
APGDTGGDPI TGYEVSTDDG TTWAPLAANR TVTGLTNGAS YTFRVRAVNS VGPGPATAGS
TATPATTPGA PTGVTATPGD NRAVVTFTPP ASDGGSPITG YEVSTDDGVS WDTLAADGTV
TGLSNNTTYT IRVRALNAAG PGPAGAATSV TPVDGLPGAP TALVAARGDR STTLTFTAPA
DPGSSAISGY EVSTDNGASW AALAPDRRVT GLANGTTYTV QVRAVNDAGA GPASGGATVT
PAAAPGAPAE VRASRGNRSA TLTFTAPVND GGDPITGYQV STDNGATWVT LAGDRTVTGL
TNGTTYAIRV RAVNGVGPGT PSAPVTVTPA TSSGAPTALV AVRGNGSAAL SFTAPDDTGG
DPVTGYQVST DNGVTWASLA GDRVVTGLTN GVTYTIRVRA VNSSGPGAAS APALVTPATA
PGMPTGLSAT AGDGTATLMF RAPDDGGDQI TGYEVSVDDG TTWAALAGDH IVTGLTNATT
YTVRIRALNS AGTGPPSASA TVTPIAGVPG APTGLTAVRG DSSVTLTWTA PADPGSSAIT
GYDVSTDAGV TWTALAGDGI VTGLTNGTAY DFWVRARNAV GPGPASDSVT ATPATTPQAP
TALTANPGDT TVTLAFRAPV DDGGAVIIGY DVSTDDGGTW AALPGDRTIT GLTNGNAYTI
RVRAVNDVGA GPAGDPVTAT PSQGRPGVVT GLSATAGNTT ATLSFTAPAD PGSSAITGYD
VTIDGGVTWT PLAGNRVVTG LTNGTAYFIA VRARNSTGAG PAGAEVMVIP VTTSAAPTGL
TADAGDSVAT LTFTAPADTG GDPVTGYEVS TDNGTTWSPL TVSGTTTLTG TVTGLTNGTP
YPVRVRALTA AGPGAPSDSV TVTPATAADA PASFAVTAGD SSLQLMFSPP ASDGGNPVTG
YEVSVDDGTT WAAVAGDRIV TGLTNGVTYQ VRVRAVTAAG PGAATDAVTI TPVGGLPGAP
TGLSVTRGDR SATATFTPPA DPGSSAITGY EVSTDDGWNW APLAPSGVIP ALTNGTTYVV
RVRAVNTTGA GPAGDGVPVT PAAVPGPPTG LRVTAGDTTA TVAFTAPADD GGAAITGYEV
STDNGVTWAA LANDRRIPGL TNGTTYSVRV RAVNDVGAGP AGAAVTVTPR ALPGAPTDVT
ATPGNASATI AFTPPADGGA TITGYEVSTD NGATWRSLAA NGTVPDLTNG TTYTVRIRAR
NSAGAGPASA AVTVTPAAVP GAPTDLTAVP GDGTATLSFT APAAGGSAIT GYDVSTDDGV
TWAPLAGGVV TGLTNGDTYT VRVRARNSVG AGPASNPVTV TPATVPDAPA GLTATPGNAS
ISVTFSPPAD GGSPITGYEA SSNNGTTWSP LTVSGATTRT GTLTGLDNGT TYAVRVRARN
SAGAGPASAN ATATPTAGLP GTPGGVSVAR GNASATVTFT PGGGTVTGYQ VSTDDGETWR
TLPADGTITG LTNGVTYAVR IRAVNNSGTS AASPSVTVTP ATTPGAPTQV TAVRGDRSAT
LTFTPPAGDG GAPITGYETS VDGGDTWTVL GDDGVVGGLS NGTAYTIRVR ARNDVGAGPA
AVAPPVTPAA GPGAPTGVSA VPGDGRVTVT FTPPASDGGS TITGYEVSVD NGTTWAALAG
TGIVTGLTNG TAYTIRVRAL SGAGTGPASA AVTVTPATVP ASPTGLSAAP GDASATVTFS
PPNAGGSPIT RYEISTDDGA SWATLAVAGT GATRTGMVDG LTNGAEVQVR VRARNDVGPG
APSAAVAVTP VTGLPSAPGD VTVTPGNASV SIAFTPPTGG VTSYEVSIDD GVTWTTLAGN
GIVAGLTNGT AYTVRIRARN ATGAGPASPG YVTTPATTPA APTALSATRG PGSATLTFTP
GATGGTPVTS YETSIDGGAT WQTLQAGGIV TGLTNGTAYT IAVRARNAVG AGAIATVTVT
PATTPGAPTA VTAARGDASA SVAFTAPAST GGAAILRYEV SVDNGTTWAT LAGNRIVTGL
TNGTAYAIRL RAVNEVGAGA PSATASVTPA TTPGAPTAVA VSPGDASASV NFTAPASTGG
AAITGYQVST DNGTTWAALA GNRIVTGLTN GTAYLIRVRA VNEVGTGAPS AATTVTPAVA
LPGAPTGLTV TRGDGSATVA FTAGGGDPVS YEVSADGGVT WTALAADRVV TGLTNGTTYA
IAVRAVNPAG AGPATPAVTV TPATLPGAPT LGSVVFTTTS VTITFTAPAT DGGSPVTAYE
LSLDGGATFN PVTPTGTGTL TVTVTGLTSG TVYAVALRAR NAVGAGPADS EFAASTPPAA
PTQLAVTRGD ASATLTFTPP DDETITGYQV STDNGATWTD LAVEGTSPLT ATVTGLDNTS
TYRFRVRAVN EAGPGRASDA VTSTVATAPG APQAVTATGR TSSILVTWAP PDNSPVPVTG
YRAVASPGPA TCTTGPSETS CVLGGRAGVE YTVRVVALST GGSTTSTASA TATPVAPSLP
TAPPSSAPSL TTADGDITTA VPGQEIVLVG DGFAPHSTVQ IAVYSKPQLL DTVVTDADGS
FRKLVRLPAG LAAGQHTLLA TGVDPDGNVL VRTLSVTVKA ATSAPTAPSV DPEPGTSMPK
TGQNIALVAA LGLLMICVGT GLVLVRRDRR
//
