ID U5W3I1_9ACTN Unreviewed; 494 AA.
AC U5W3I1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN ORFNames=AFR_27560 {ECO:0000313|EMBL:AGZ43773.1};
OS Actinoplanes friuliensis DSM 7358.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1246995 {ECO:0000313|EMBL:AGZ43773.1, ECO:0000313|Proteomes:UP000017746};
RN [1] {ECO:0000313|EMBL:AGZ43773.1, ECO:0000313|Proteomes:UP000017746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7358 {ECO:0000313|EMBL:AGZ43773.1,
RC ECO:0000313|Proteomes:UP000017746};
RX PubMed=24637369; DOI=10.1016/j.jbiotec.2014.03.011;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Fischer N.,
RA Steinkamper A., Puhler A., Biener R., Schwartz D., Kalinowski J.;
RT "Complete genome sequence of the actinobacterium Actinoplanes friuliensis
RT HAG 010964, producer of the lipopeptide antibiotic friulimycin.";
RL J. Biotechnol. 178:41-42(2014).
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DR EMBL; CP006272; AGZ43773.1; -; Genomic_DNA.
DR RefSeq; WP_023560111.1; NC_022657.1.
DR AlphaFoldDB; U5W3I1; -.
DR STRING; 1246995.AFR_27560; -.
DR KEGG; afs:AFR_27560; -.
DR PATRIC; fig|1246995.3.peg.5586; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_1_10_11; -.
DR OrthoDB; 3955596at2; -.
DR Proteomes; UP000017746; Chromosome.
DR GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:InterPro.
DR CDD; cd07085; ALDH_F6_MMSDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR010061; MeMal-semiAld_DH.
DR NCBIfam; TIGR01722; MMSDH; 1.
DR PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000017746}.
FT DOMAIN 14..474
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 494 AA; 52199 MW; C28E8FE1226325DF CRC64;
MREIKHWIDG TAVEGTSGRQ LPVWDPATGE QQAYVVAATA DETAKAVASA KAAFPAWRAA
SLSRRAEVMF RFRELVDANR KEIASLVSQE HGKTVADAGG ELARGLENIE FAAGAPHLLK
GGYSEQASSG VDVYSIRQPL GVVAGITPFN FPAMVPMWMF CNALVCGNTF ILKPSEKDPS
VSLMLADLLR QAGLPDGAFN VVQGDREAVE TLIAHPDVQA LSFVGSTPVA RIIYETATAK
GKRVQALGGA KNHMVVLPDA DVNAAADAAV SAGYGSAGER CMAVSVVVAV GSVGDDLVAA
ISDRIGRIAV GPASDPAAEM GPLISREHRD KVAGYLADAG TAEVVVDGRD APISDGPGFF
LGASLVDKVP TDSPLYTDEI FGPVLSVVRT ETYEEALDLV NTNEYGNGTA IFTRDGGAAR
RFQYDVNCGM VGVNVPVPVP VAYYSFGGWK SSLFGDLHMY GPEGLQFYTR SKVVTSRWPD
PATSEIDLGF PKVR
//
