ID U5W4I4_9ACTN Unreviewed; 1988 AA.
AC U5W4I4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Putative non ribosomal peptide synthetase protein {ECO:0000313|EMBL:AGZ44108.1};
GN ORFNames=AFR_29235 {ECO:0000313|EMBL:AGZ44108.1};
OS Actinoplanes friuliensis DSM 7358.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1246995 {ECO:0000313|EMBL:AGZ44108.1, ECO:0000313|Proteomes:UP000017746};
RN [1] {ECO:0000313|EMBL:AGZ44108.1, ECO:0000313|Proteomes:UP000017746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7358 {ECO:0000313|EMBL:AGZ44108.1,
RC ECO:0000313|Proteomes:UP000017746};
RX PubMed=24637369; DOI=10.1016/j.jbiotec.2014.03.011;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Fischer N.,
RA Steinkamper A., Puhler A., Biener R., Schwartz D., Kalinowski J.;
RT "Complete genome sequence of the actinobacterium Actinoplanes friuliensis
RT HAG 010964, producer of the lipopeptide antibiotic friulimycin.";
RL J. Biotechnol. 178:41-42(2014).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP006272; AGZ44108.1; -; Genomic_DNA.
DR STRING; 1246995.AFR_29235; -.
DR KEGG; afs:AFR_29235; -.
DR PATRIC; fig|1246995.3.peg.5924; -.
DR eggNOG; COG1020; Bacteria.
DR eggNOG; COG3319; Bacteria.
DR HOGENOM; CLU_000022_0_9_11; -.
DR OrthoDB; 5476914at2; -.
DR Proteomes; UP000017746; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000017746}.
FT DOMAIN 514..589
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1565..1640
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1646..1721
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1988 AA; 215116 MW; 7641C85305B47AD7 CRC64;
MLDSSPGNPP TLPELFAAQV EHGASEVAVV GDDASLSFAE LDERSNRLAR LLIDQGVGPE
VVVALRMSRS VDFVVAALAV VKAGGAYVPV DVAYPAARAE FMMADARARC VVTTTSAASP
GSSAIPQVVL DDPKVVDELA GLDGHAVRDA DRHEELLPDH AAYLIFTSGS TGVPKGVVVT
HRSAQNLVRA QAQILGLGPG RRRLQFASVS FDASVSEVWT TLLSGAALVV ADASRLVPGP
ALVDLVRSRG VTHVTLPPSL LSAVEDAGGL PDAVTLVVAG EACPPAVAAR WCRDRRMLNA
YGPTEATVAA TVSDPLTGDG TPPIGRPLPN VRVYVLDELL REQPVGVPGE LYLAGAGLAR
GYAGRTALTA QRFVADPFGT PGERMYRTGD VVRRRADGQL EYQGRADDQV KIRGVRVEPG
EIESALMGLA GVDQAVVVAH GDGADRRLVA YVVADADGPD AAGLRRNLAA VVPDHLVPSV
FTMLDSMPVT VNGKVDRKAL PDPAGDAGVR DFVPPVGAVE QTLARLWEDV LGVPRVGRTD
EFYRLGGHSL LATQLVNRVR TAMNVELPVR DLFETSTLAD LARRVSVLKS GTRPVLRRQV
RAATVPLSYP QQQMWLTAQL RGGDGAYHIP VVVRLSDGLD EAALRAAITD IVRRHEPLRT
RFPVLEGQPR QQVVPMADLG ELLVREPVAA GDREDTVRRV VREGFDLTTQ IPLRARLLEF
GPDDFVLVLV LHHITADGAS MEPLMRDLQE AYERRRAGRP PQWTELPVQY ADFAVWQREL
VRLARPQIAY WRDLLADAPH ELALPVDRGR PAEPTYRGRS VPISVPAEVH EQIAATARRH
GATVFMVLQS AVAALLSRLG AGTDVPLGWP VSGRVDEALE DLVGFFVNTL VLRADLTGDP
SFDELIGRVR EQDLLAFGHQ DVPFESVVEE LNPPRVPGRH PLFQVMVASQ VGRSARFGLA
GVRSERMGVG SGSAKFDLSV QFVEFLDESG RPSGLGGEVM YACDLFDHDT VERMVGMLGR
LLAEAVAQPG LPIGRLPVMS GEERLAVEAA STGDVRDWAA RPWPHQLVEQ HARRNPDAIA
VRFEGVDLPY GELNRRANQL AHHLIELGAG RETLVGISME RGFDLVVGVL AIWKTGGAFV
PLDPDLPAAR LTSMIGDAAV GVVLTHRATQ DRLAAHDDLL LCVDGPDTDL AARPSHDPGV
PVDGEDAVYA IYTSGSTGTP KGVVNVRAAI RNRLTWMNER FGAGTDGRVL QKSPFTFDTS
VWELFWALTN GATLVMARPD GHRDPRYLVD LIQREQVTLV DFVPSMLEMF LREPDAARCT
SLRHVIAGGE TLTRSLRSRF AEALPQTEIY NLYGPTEAAI GVTSWLCRDD DDSRSAPIGV
PIANARVYVL GPDLGHVPPG MPGEIYIAAR PLARGYLNRA DLTAQRFVAD PFVAGERMYR
TGDRARRRPD GAIEFLGRDD EQVKIRGVRV ELGEVEAALL GLHGVEQAVV TVHGDGVDKR
LVAYVVGFDP DPVRLRRQMP AVVPAHLVPS AFVAMDAFPV TVNGKVDRRQ LPDPGVVDTD
RAYEAPAGPI EESLAGLWQE LLSVARVGRD DNFFALGGHS LLAMQMVNEI RSLLRVELPF
RTVFESSTLA DLAARIGDLP LLPDADSQAS PEDRMRVLVA QALGVDEVAA EDNLFDLGGG
RETVEALTRA IEAEFGMTVN PLVVSAVPTA KDLAGWLAAE PEEATLDVVV PLRPGTTPES
LFCIHPLGGL SWLYYPLVNA IPSAVGVYGV QARGLGPGEE LPTTMTAMAA DYVQQIRLVQ
PEGPYHLLGL STGGEIAHEM GVQLQRGGEE VALIAMLDAR PTPQRPATQV ERLNAVAHHF
DLNVPAEERP HLTGDILYEQ LRQRQGPYSF LMRQKGRATV DFYENMIKVA DGHKFSVFDG
DVLFIEAIAA RPEEHYFAPM WHPYVSGAVD VMALDYKHRQ LARAEVLQLI GARVAEHLRL
TPTEGPTA
//
