ID   U5WSJ2_MYCKA            Unreviewed;       567 AA.
AC   U5WSJ2;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=3-ketosteroid-delta-1-dehydrogenase {ECO:0000313|EMBL:AGZ50876.1};
GN   ORFNames=MKAN_11850 {ECO:0000313|EMBL:AGZ50876.1};
OS   Mycobacterium kansasii ATCC 12478.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=557599 {ECO:0000313|EMBL:AGZ50876.1, ECO:0000313|Proteomes:UP000017786};
RN   [1] {ECO:0000313|EMBL:AGZ50876.1, ECO:0000313|Proteomes:UP000017786}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12478 {ECO:0000313|EMBL:AGZ50876.1,
RC   ECO:0000313|Proteomes:UP000017786};
RG   McGill University Mycobacterium genome consortium;
RA   Veyrier F.J., Behr M.A.;
RT   "Genome sequence of Mycobacterium kansasii.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR   EMBL; CP006835; AGZ50876.1; -; Genomic_DNA.
DR   AlphaFoldDB; U5WSJ2; -.
DR   KEGG; mkn:MKAN_11850; -.
DR   eggNOG; COG1053; Bacteria.
DR   HOGENOM; CLU_011398_4_2_11; -.
DR   Proteomes; UP000017786; Chromosome.
DR   GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR   GO; GO:0008202; P:steroid metabolic process; IEA:UniProt.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR   PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   PRINTS; PR00469; PNDRDTASEII.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE   4: Predicted;
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          10..548
FT                   /note="FAD-dependent oxidoreductase 2 FAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF00890"
SQ   SEQUENCE   567 AA;  61282 MW;  ABD3ABC94D35D9F7 CRC64;
     MFYMTAQDYD VVVVGSGGAG MVAALTAAHR GLSPVVVEKA AHYGGSTARS GGGVWIPNNE
     VLKRAGVRDS SEAARTYLHG IIGDVSTSGV EPERIDAYLE HGPQMLSFVL KHTPLKMCWV
     PGYSDYYPEA PGGLPSGRSI EPKPFNARKL GPDEATLEPP YGKVPLNVVV MQQDYVRLNQ
     LKRHPRGVLR SLKVGARTML AKATGKNLVG MGRALIGPLR IGLRQAGVPV LLNTALTDLY
     VEEDVVRGIY VRDADASEAA EPRLIRARRG VILACGGFEH NEQMRVKYQR APITTEWTVG
     AKANTGDGIV AGEKLGAALD LMDDAWWGPT VPLVGKPWFA LSERNSPGSI IVNMSGNRFM
     NESMPYVEAC HHMYGGKYGQ GPGPGENIPA WLVFDQQYRD RYIFAGLQPG QRIPRKWLDS
     GVIIQAETLE ELATKAGLPV DQFIATVQRF NGFARSGVDT DYHRGESAYD RYYGDPTNKP
     NPNLGEIRHA PYYAAKMVPG DLGTKGGIRT DVHGRALRDD GSIIDGLYAA GNVSSPVMGH
     TYPGPGGTIG PAMTFGYLAA LHIAGER
//