ID   U6CWH3_NEOVI            Unreviewed;       314 AA.
AC   U6CWH3;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Tumor necrosis factor receptor type 1-associated DEATH domain protein {ECO:0000256|ARBA:ARBA00015474};
GN   Name=TRADD {ECO:0000313|EMBL:CCP74202.1};
OS   Neovison vison (American mink) (Mustela vison).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Neogale.
OX   NCBI_TaxID=452646 {ECO:0000313|EMBL:CCP74202.1};
RN   [1] {ECO:0000313|EMBL:CCP74202.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Pool of brain {ECO:0000313|EMBL:CCP74202.1};
RA   Anistoroaei R., Christensen K.;
RT   "An American mink transcriptome.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNVIP00000013503.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; HAAF01002376; CCP74202.1; -; mRNA.
DR   Ensembl; ENSNVIT00000015786.1; ENSNVIP00000013503.1; ENSNVIG00000010625.1.
DR   GeneTree; ENSGT00390000002016; -.
DR   OrthoDB; 5354303at2759; -.
DR   Proteomes; UP000694425; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0002947; C:tumor necrosis factor receptor superfamily complex; IEA:Ensembl.
DR   GO; GO:0070513; F:death domain binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; IEA:Ensembl.
DR   GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0051798; P:positive regulation of hair follicle development; IEA:Ensembl.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
DR   CDD; cd08780; Death_TRADD; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.30.70.680; TRADD, N-terminal domain; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR035712; TRADD.
DR   InterPro; IPR009095; TRADD_N.
DR   InterPro; IPR036729; TRADD_N_sf.
DR   PANTHER; PTHR14913; TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR14913:SF0; TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF09034; TRADD_N; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF55044; TRADD, N-terminal domain; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Receptor {ECO:0000313|EMBL:CCP74202.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694425}.
FT   DOMAIN          217..307
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          165..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..188
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  34872 MW;  8B02DCF4236B842F CRC64;
     MATGPNGLDE WVGSAYLFVE SSLDKVVLSD AYAHAQQKVP VYRALRTALT ESGGSPDVLQ
     MLKIHRSEPQ LIVQVRFRGR QPCSRFLRAY REGSLRATLQ ECLAGALALH SVPLQLELRA
     GTERLDTLLT DEERCLSCIF AQKPDRLRDE ELSELEEALR NLTCGSGSQS GNMEVVPAPS
     QSLATSLSEE KPPAPPPPPP VQTFLFQGQP IVNRPLSLQD QQTFARSVGV KWRKVGRSLQ
     RGCRALRDPA LDSLAYEYER EGLYEQAFQM LRRFVQAEGR RATLQRLVEA LEENELTSLA
     EDLLGLTNPD GSLA
//