ID   U6D1R1_NEOVI            Unreviewed;      1791 AA.
AC   U6D1R1;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   SubName: Full=Neurofibromin {ECO:0000313|EMBL:CCP76591.1};
DE   Flags: Fragment;
GN   Name=NF1 {ECO:0000313|EMBL:CCP76591.1};
OS   Neovison vison (American mink) (Mustela vison).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Neogale.
OX   NCBI_TaxID=452646 {ECO:0000313|EMBL:CCP76591.1};
RN   [1] {ECO:0000313|EMBL:CCP76591.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Pool of brain {ECO:0000313|EMBL:CCP76591.1};
RA   Anistoroaei R., Christensen K.;
RT   "An American mink transcriptome.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HAAF01004766; CCP76591.1; -; mRNA.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   CDD; cd05130; RasGAP_Neurofibromin; 1.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          1231..1426
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   DOMAIN          1555..1713
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CCP76591.1"
FT   NON_TER         1791
FT                   /evidence="ECO:0000313|EMBL:CCP76591.1"
SQ   SEQUENCE   1791 AA;  202247 MW;  A2CBE5C88E76ED77 CRC64;
     VEWVQAVVSR FDEQLPIKTG QQNTHTKVST EHNKECLINI SKYKFSLVIS GLTTILKNVN
     NMRIFGEAAE KNLYLSQLII LDTLEKCLAG QPKDTMRLDE TMLVKQLLPE ICHFLHTCRE
     GNQHAAELRN SASGVLFSLS CNNFNAVFSR ISTRLQELTV CSEDNVDVHD IELLQYINVD
     CAKLKRLLKE TAFKFKALKK VAQLAVINSL EKAFWNWVEN YPDEFTKLYQ IPQTDMAECA
     EKLFDLVDGF AESTKRKAAV WPLQIILLIL CPEIIQDISK DVVDENNMNK KLFLDSLRKA
     LAGHGGSRQL TESAAIACVK LCKASTYINW EDNSVIFLLV QSMVVDLKNL LFNPSKPFSR
     GSQPADVDLM IDCLVSCFRI SPHNNQHFKI CLAQNSPSTF HYVLVNSLHR IITNSALDWW
     PKIDAVYCHS VELRNMFGET LHKAVQGCGA HPAIRMAPSL TFKEKVTSLK FKEKPTDLET
     RSYKYLLLSM VKLIHADPKL LLCNPRKQGP ETQGSTAELI TGLVQLVPQS HMPEIAQEAM
     EALLVLHQLD SIDLWNPDAP VETFWEISSQ MLFYICKKLT SHQMLSSTEI LKWLREILIC
     RNKFLLKNKQ ADRSSCHFLF LYGVGCDVPS SGTTGQMSMN HEELLPSCTP GASLRKGKGN
     SSMDSAAGCS GTPPICRQAQ TKLEVALYMF LWSPDTEAVL VAMSCFRHLC EEADIRCGVD
     EVSVHNFLPN YNTFMEFASV SNMMSTGRAA LQKRVMALLR RIEHPTAGNT EAWEDTHAKW
     EQATKLILNY PKAKMEDGQA AESLHKTIVK RRMSHVSGGG SIDLSDTDSL QEWINMTGFL
     CALGGVCLQQ RSNSGLATYS PPMGPVSERK GSMISVMSSE GNADTPVSKF MDRLLSLMVC
     NHEKVGLQIR TNVKDLVGLE LNPALYPMLF NKLKNTISKF FDSQGQVLLT DTNTQFVEQT
     IAIMKNLLDN HTEGSSEHLG QASIETMMLN LVRYVRVLGN MVHAIQIKTK LCQLVEVMMA
     RRDDLSFCQE MKFRNKMVEY LTDWVMGTSN QAADDDVKCL TRDLDQASME AVVSLLAGLP
     LQPEEGDGVE LMEAKSQLFL KYFTLFMNLL NDCSEVEDEN AQTGGRKRGM SRRLASLRHC
     TVLAMSNLLN ANVDSGLMHS IGLGYHKDLQ TRATFMEVLT KILQQGTEFD TLAETVLADR
     FERLVELVTM MGDQGELPIA MALANVVPCS QWDELARVLV TLFDSRHLLY QLLWNMFSKE
     VELADSMQTL FRGNSLASKI MTFCFKVYGA TYLQKLLDPL LRIVITSSDW QHVSFEVDPT
     RLEPSESLEE NQRNLLQMTE KFFHAIISSS SEFPPQLRSV CHCLYQVVSQ RFPQNSIGAV
     GSAMFLRFIN PAIVSPYEAG ILDKKPPPRI ERGLKLMSKI LQSIANHVLF TKEEHMRPFN
     DFVKSNFDAA RRFFLDIASD CPTSDAVNHS LSFISDGNVL ALHRLLWNNQ EKIGQYLSSN
     RDHKAVGRRP FDKMATLLAY LGPPEHKPVA DTHWSSLNLT SSKFEEFMTR HQVHEKEEFK
     ALKTLSIFYQ AGTSKAGNPI FYYVARRFKT GQINGDLLIY HVLLTLKPYY AKPYEIVVDL
     THTGPSNRFK TDFLSKWFVV FPGFAYDNVS AVYIYNCNSW VREYTKYHER LLTGLKGSKR
     LIFIDCPGKL AEHIEHEQQK LPAATLALEE DLKVFHNALK LAHKDTKVSI KVGSTAVQVT
     SAERTKVLGQ SVFLNDIYYA SEIEEICLVD ENQFTLTIAN QGTPLTFMHQ E
//