ID U6D609_NEOVI Unreviewed; 952 AA.
AC U6D609;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE Flags: Fragment;
GN Name=DHX36 {ECO:0000313|EMBL:CCP77527.1};
OS Neovison vison (American mink) (Mustela vison).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Neogale.
OX NCBI_TaxID=452646 {ECO:0000313|EMBL:CCP77527.1};
RN [1] {ECO:0000313|EMBL:CCP77527.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pool of brain {ECO:0000313|EMBL:CCP77527.1};
RA Anistoroaei R., Christensen K.;
RT "An American mink transcriptome.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; HAAF01005703; CCP77527.1; -; mRNA.
DR AlphaFoldDB; U6D609; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17981; DEXHc_DHX36; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934:SF237; ATP-DEPENDENT DNA_RNA HELICASE DHX36; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:CCP77527.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 222..392
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 482..652
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 952
FT /evidence="ECO:0000313|EMBL:CCP77527.1"
SQ SEQUENCE 952 AA; 107974 MW; 640179D61C5D7E95 CRC64;
MSYDYHQNWG RDGGPRNSGG GYGGSYGAGH GGGHGGNRGS GGGGGGGGGG GGRGGRGRHP
GHLKGREIGL WYAKKQGQKN KEAERQERAV VHMDERREEQ IVQLLHSVQA KNGKDAEAQI
SWFAPEDHGY GTESPTENKP NSEKKLENQE KKLISQEKRT FRIRDKYIDR DSEYLLQENE
PDVTLDQQLL EDLRKKKSDL RYIEMQHFRE KLPSYGMQKE LVNMIDNHQV TVISGETGCG
KTTQVTQFIL DNYIERGKGS ACRIVCTQPR RISAISVAER VAAERAESCG NGNSTGYQIR
LQSRLPRKQG SILYCTTGII LQWLQSDSHL SSVSHIVLDE IHERNLQSDV LMTVIKDLLS
FRPDLKVILM SATLNAEKFS EYFGNCPMIH IPGFTFPVVE YLLEDIIEKI RYVPEQKEHR
SQFKRGFMQG HVNRQEKEEK EAIYKERWPD YVRELRKRYS ASTVDVLEMM DDDKVDLNLI
AALIRHIVLE EEDGAILVFL PGWDNISTLH DLLMSQVMFK SDRFLIIPLH SLMPTVNQTQ
VFKRTPPGVR KIVIATNIAE TSITIDDVVY VIDGGKIKET HFDTQNNIST MSAEWVSKAN
AKQRKGRAGR VQPGHCYHLY NGLRASLLDD YQLPEILRTP LEELCLQIKI LRLGGIAYFL
SRLMDPPSDE AVSLSIKHLM ELNALDKQEE LTPLGVHLAR LPVEPHIGKM ILFGALFCCL
DPVLTIAASL SFKDPFVIPL GKEKIADARR KELAKDTKSD HLTVVNAFEG WEEARRRGFR
YEKDYCWEYF LSSNTLQMLH NMKGQFAEHL LGAGFVSSRN PKDPKSNINS DNEKIIKAVI
CAGLYPKVAK IRLNLGKKRK MVKVYTKTDG LVAIHPKSVN VEQTEFHYNW LIYHLKMRTS
SIYLYDCTEV SPYCLLFFGG DISIQKDNDQ ETIAVDEWIV FQSPARIAHL VK
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