ID U6DYC3_NEOVI Unreviewed; 201 AA.
AC U6DYC3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 {ECO:0000256|ARBA:ARBA00015644};
DE EC=2.4.99.20 {ECO:0000256|ARBA:ARBA00012600};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
DE AltName: Full=2'-phospho-ADP-ribosyl cyclase {ECO:0000256|ARBA:ARBA00031840};
DE AltName: Full=2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase {ECO:0000256|ARBA:ARBA00030418};
DE AltName: Full=2'-phospho-cyclic-ADP-ribose transferase {ECO:0000256|ARBA:ARBA00029787};
DE AltName: Full=ADP-ribosyl cyclase 1 {ECO:0000256|ARBA:ARBA00031355};
DE AltName: Full=Cyclic ADP-ribose hydrolase 1 {ECO:0000256|ARBA:ARBA00030272};
DE Flags: Fragment;
GN Name=CD38 {ECO:0000313|EMBL:CCP86918.1};
OS Neovison vison (American mink) (Mustela vison).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Neogale.
OX NCBI_TaxID=452646 {ECO:0000313|EMBL:CCP86918.1};
RN [1] {ECO:0000313|EMBL:CCP86918.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pool of brain {ECO:0000313|EMBL:CCP86918.1};
RA Anistoroaei R., Christensen K.;
RT "An American mink transcriptome.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000457};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ADP-ribosyl cyclase family.
CC {ECO:0000256|ARBA:ARBA00005406}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HAAF01015096; CCP86918.1; -; mRNA.
DR AlphaFoldDB; U6DYC3; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR InterPro; IPR003193; ADP-ribosyl_cyclase.
DR PANTHER; PTHR10912; ADP-RIBOSYL CYCLASE; 1.
DR PANTHER; PTHR10912:SF5; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE 1; 1.
DR Pfam; PF02267; Rib_hydrolayse; 1.
DR SUPFAM; SSF52309; N-(deoxy)ribosyltransferase-like; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT NON_TER 201
FT /evidence="ECO:0000313|EMBL:CCP86918.1"
SQ SEQUENCE 201 AA; 22816 MW; 534040D8BB972E20 CRC64;
MANHRCGSVS EEEPCCDISK KTKICLCVFF GLLVAVIIAV PVGILMWRHP LKEWKGKGTT
AHFHEILLGR CYTYTQIVRP DLGHKDCQKI GKAFTTAFLS KDPCSSTEQD YQPLLELTAQ
TVPCNKTLFW SKSSELAHDY TRVQGDLFTL EDTLLGYMAD GLKWCGDPHS SEMNYQSCPD
WRQDCTNNSF SVFWNAVSKR F
//
