ID   U6G984_EIMAC            Unreviewed;      1032 AA.
AC   U6G984;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Glycine hydroxymethyltransferase, putative {ECO:0000313|EMBL:CDI76821.1};
GN   ORFNames=EAH_00019840 {ECO:0000313|EMBL:CDI76821.1};
OS   Eimeria acervulina (Coccidian parasite).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX   NCBI_TaxID=5801 {ECO:0000313|EMBL:CDI76821.1};
RN   [1] {ECO:0000313|EMBL:CDI76821.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Houghton {ECO:0000313|EMBL:CDI76821.1};
RA   Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA   Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA   Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA   Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA   Tomley F., Pain A.;
RT   "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDI76821.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Houghton {ECO:0000313|EMBL:CDI76821.1};
RA   Aslett M.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K
CC       subfamily. {ECO:0000256|ARBA:ARBA00008941}.
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DR   EMBL; HG670470; CDI76821.1; -; Genomic_DNA.
DR   RefSeq; XP_013252707.1; XM_013397253.1.
DR   AlphaFoldDB; U6G984; -.
DR   EnsemblProtists; CDI76821; CDI76821; EAH_00019840.
DR   GeneID; 25270054; -.
DR   VEuPathDB; ToxoDB:EAH_00019840; -.
DR   OrthoDB; 1699at2759; -.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   InterPro; IPR044571; P4KG1-8.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   PANTHER; PTHR45800; PHOSPHATIDYLINOSITOL 4-KINASE GAMMA; 1.
DR   PANTHER; PTHR45800:SF11; PI3K_PI4K CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000313|EMBL:CDI76821.1};
KW   Transferase {ECO:0000313|EMBL:CDI76821.1}.
FT   DOMAIN          153..481
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00454"
FT   REGION          648..765
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          796..848
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          860..881
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          964..1032
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        723..756
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        976..998
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1032 AA;  112434 MW;  618D5D640B98A904 CRC64;
     MPAVEGPAAA GGAGGGGGVM MLPSHPLYYF STHNALRGAD GDDLHFRVCF EELHGSRSCE
     LDVYPFYDVQ MVKDVRLIFR GCELPNWRPM TVFFENPVKR LLWAVRGGSA QASIRPFARS
     QTFRSKELLR ILEEVRLGFR RNVAPKLTMD GTGGTYILFD GRRRPVAVFK PEDEEAFAPC
     NPRGYEGRLG QQGLRGGVLS GEGAGREFAA YLLDASYGGF AGVPATMMVE ACHPAFCSRG
     QIEVDGDVMM STYVRSESSP SVSWKVGSFQ AFVEAKECVG NFDARLFSVG DVHRIAIFDL
     RVMNLDRNDS NILVAPVVGY QKEPSAGGSS RSLRASGGVV KQIESKLLRS VSAVGSCGTQ
     LCVADKAAVA GAETAASAAS GVLTPDGKPT KWSNRRFRLI PIDHGMILTD VLDVATLDLV
     WFDWPQSKEP YSESELRLIY SFDVDKDLER LSRRVALRDN CLRTLRLATK LLQICARHHL
     TVRETATIAV RDDFDIPSPL EHLIRRSLEI SYLALDSTSL MSTNRLGFGI MDLAELQGDP
     GKQQGLRRTS FEAKLKKAFR KKKRGGDEGP VEETAVDANG ICSRCGGFVA VSGAAAVSTA
     VITSVSCRVP STLDPDGEVD SEEFEERPLL RSCTTIEAWS DARSPVGAHA EVDVSEPRAS
     RNTAAAALDR ATVQPAGSRL HSVENVRGRL PSGSAEDERQ TAGGTAPCRC GDRIERRSSS
     SLGDSADSDS DLTSNSLSTS SNDGTQSSWT SSHSDDDSSK AASEVGARLA PPTFGSFQAP
     GAAGGPLRHL PSAALFRYPS GEPRFSGRQK RRTSRSRRRK APTETETKTD DAAPAVPSPP
     RNEPAVFGNR HTKGTVRRLN GTARGTGCRP KKQPSATQST WSLTDSSGRV ILLDWRDGRL
     EKLFFEVYES LLRQHILHNH PQWFTYPYNG EAIERSERRQ QSFRREESGS LVTPLVATPT
     VHVNSQQIHA TNTHRRLSSE ASDDASASAA DRHLTHKHLR SVQQPQPQSP AQLEDRAPAA
     SRQTRFNISS DA
//